A5005836986- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Cerebral Palsy and Movement Disorders
- Medicinal Plants and Neuroprotection
- Transcranial Magnetic Stimulation Studies
- Mindfulness and Compassion Interventions
- Tendon Structure and Treatment
- Pharmacology and Obesity Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Natural Antidiabetic Agents Studies
- Adenosine and Purinergic Signaling
- Molecular Biology Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Venous Thromboembolism Diagnosis and Management
- Antioxidant Activity and Oxidative Stress
- Fibromyalgia and Chronic Fatigue Syndrome Research
Universidade Estadual de Campinas (UNICAMP)
2013-2024
University of California, San Diego
2022
Abstract The hyperphosphorylation of microtubule‐associated protein tau (tau) in the hippocampus can be caused by central and peripheral insulin resistance these alterations are related to development tauopathies, such as Alzheimer's disease. In this study, we used a high‐fat diet induce obesity adult Swiss mice checked whether supplementation with Myrciaria jaboticaba berry peel for 10 weeks could improve sensitivity, learning/memory performance, prevent phosphorylation hippocampus....
Brain-derived neurotrophic factor (BDNF) has a critical role in stress response including neuropsychiatric disorders that are precipitated by stress, such as major depressive disorder (MDD). BDNF acts through its full-length receptor tyrosine kinase B (TrkB) to trigger pro-plasticity effect. In contrast, the truncated isoform of (TrkB.t1) triggers an anti-plasticity outcomes, acting hippocampus resilience effect, and, inversely, nucleus accumbens (NAc), susceptible molecule. It is unknown if...
Injuries to peripheral nerves cause loss of motor and sensory function, greatly affecting life quality. Successful repair the lesioned nerve requires efficient cell debris removal, followed by axon regeneration reinnervation target organs. Such process is orchestrated several cellular molecular events in which glial immune cells actively participate. It known that tissue clearance largely improved macrophages, activation potentiated molecules acquired system, such as T helper lymphocytes...
In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) and investigated proofs peripheral insulin resistance, hippocampal AKT–GSK3-β–tau activation, learning/memory performance, brain frontal lobe oxidative stress. The intake HS did not prevent weight gain but promoted sensitivity, improved AKT signaling in the hippocampus, which prevented activation GSK3-β lowered tau phosphorylation induced HF. results from Morris water maze...
Peripheral inflammatory hyperalgesia depends on the sensitization of primary nociceptive neurons. Inflammation drives molecular alterations not only locally but also in dorsal root ganglion (DRG) where interleukin-1 beta (IL-1β) and purinoceptors are upregulated. Activation P2X7 by ATP is essential for IL-1β maturation release. At DRG, P2X7R expressed satellite glial cells (SGCs) surrounding sensory neurons soma. Although SGCs have no projections outside ganglia these affect pain signaling...
Abstract Epidemiological studies have shown a close association between pain and depression. There is evidence showing this as patients with depression show high chronic prevalence vice versa. Considering that social stress critical for the development of in humans, we used defeat ( SDS ) model which induces depressive‐like behavior mice. In model, mice are exposed to an aggressor mouse ten days, suffering brief periods agonistic contact long sensory contact. Some display avoidance,...
β-Blockers reduce temporomandibular joint (TMJ) pain. We asked whether they also TMJ inflammation and, if so, this anti-inflammatory effect contributes to its analgesic action.We measured many parameters of the inflammatory response after co-administration β-blocker propranolol with agent carrageenan in female rats. hypothesized that activation β-adrenoceptors induces nociception mediated, at least part, by response. To test hypothesis, we examined nociceptive induced rats pretreated...
Dopaminergic neurotransmission in the nucleus accumbens, a central component of mesolimbic system, has been associated with acute pain modulation. As there is transition from to chronic ('chronification'), modulatory structures may be involved development. Thus, this study aimed elucidate role accumbens dopaminergic chronification pain. We used rat model which daily subcutaneous injection prostaglandin E2 hindpaw for 14 days induces long-lasting state nociceptor sensitization that lasts at...
Recent findings from rodent studies suggest that high-fat diet (HFD) increases hyperalgesia independent of obesity status. Furthermore, weight loss interventions such as voluntary physical activity (PA) for adults with or overweight was reported to promote pain reduction in humans chronic pain. However, regardless status, it is not known whether HFD intake and sedentary (SED) behavior underlies susceptibility. Moreover, differential gene expression the nucleus accumbens (NAc) plays a crucial...
We investigated the relation between swimming exercise and fear memory extinction. Rats that performed regular over 6 wk underwent conditioning. Twenty-eight days later, they were submitted to extinction tests. Swimming rats had enhanced process throughout 5 of test compared with sedentary rats. This suggests accelerated aversive extinction, reducing expression conditioned behavior. These results encourage further studies addressing anxiolytic effects exercise, potential implications for...
Obesity and insulin resistance constitute risk factors for the development of tauopathies other neurodegenerative diseases. (Poly)phenol compounds are under study its role in protecting effects against neural injuries degeneration. Here, we investigated effect Amazonian açai pulp (AP) intake prevention memory cognitive impairment resulting from a high-fat diet mice.Obesity was induced with supplemented 2% AP to investigate peripheral resistance, recognition tau protein stability via...
Chronic pain affects significant portion of the world's population and physical exercise has been extensively indicated as non-pharmacological clinical intervention to relieve symptoms in chronic conditions. In general, studies on chronification have focused neuropathic pain, although commonly results from an original inflammatory episode. Based this, objective present study was investigate therapeutic preventive effect running wheel persistent hyperalgesia induced by repetitive stimulus, a...
[Abstract] Due to the high prevalence and great economic impact of depression, studies with animal models have been increasingly used identify neurobiological mechanisms associated this disorder. However, many use stressful conditions that are not consistent what we observe in modern human world. Examples chronic unpredictable stress electric shock model rodents. It's well established social as major cause depressive disorder human, way a defeat was recently standardized can induce...