A5088375418- Nerve injury and regeneration
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Parasites and Host Interactions
- Wound Healing and Treatments
- Immune cells in cancer
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Tendon Structure and Treatment
- Retinoids in leukemia and cellular processes
- Vagus Nerve Stimulation Research
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Laser Applications in Dentistry and Medicine
- Parasitic Infections and Diagnostics
- Erythrocyte Function and Pathophysiology
- Beetle Biology and Toxicology Studies
- Hematopoietic Stem Cell Transplantation
- Lysosomal Storage Disorders Research
- Mesenchymal stem cell research
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
Universidade Estadual de Campinas (UNICAMP)
2013-2023
University of Lisbon
2023
Universidade de São Paulo
2007-2012
Microsoft (Brazil)
2011
Institute of Biomedical Science
2009
Background The modulation of inflammatory processes is a necessary step, mostly orchestrated by regulatory T (Treg) cells and suppressive Dendritic Cells (DCs), to prevent the development deleterious responses autoimmune diseases. Therapies that focused on adoptive transfer Treg or their expansion in vivo achieved great success controlling inflammation several experimental models. Chloroquine (CQ), an anti-malarial drug, was shown reduce inflammation, although mechanisms are still obscure....
Chloroquine (CQ), an antimalarial drug, has been shown to modulate the immune system and reduce severity of experimental autoimmune encephalomyelitis (EAE). The mechanisms disease suppression are dependent on regulatory T cell induction, although Tregs‐independent exist. We aimed evaluate whether CQ is capable bone marrow‐derived dendritic cells (DCs) both phenotypically functionally as well transfer CQ‐modulated DCs reduces EAE course. Our results show that CQ‐treated presented altered...
Injuries to peripheral nerves cause loss of motor and sensory function, greatly affecting life quality. Successful repair the lesioned nerve requires efficient cell debris removal, followed by axon regeneration reinnervation target organs. Such process is orchestrated several cellular molecular events in which glial immune cells actively participate. It known that tissue clearance largely improved macrophages, activation potentiated molecules acquired system, such as T helper lymphocytes...
Tissue engineering and cell-based therapy combine techniques that create biocompatible materials for cell survival, which can improve tendon repair. This study seeks to use a new fibrin sealant (FS) derived from the venom of Crotalus durissus terrificus, biodegradable three-dimensional scaffolding produced animal components only, associated with adipose-derived stem cells (ASC) application in tendons injuries, considered common serious orthopedic problem. Lewis rats had distributed five...
Highly virulent strains of Trypanosoma cruzi are frequently used as murine models Chagas' disease. However, these do not fully represent the spectrum parasites involved in human infection. In this paper, we analysed parasitaemia, mortality, tissue pathology and parasite-specific IgG serum levels immune-deficient mice infected with Sylvio X10/4 parasites, a T. derived from chagasic patient that yields very low parasitaemias C3H/HePAS induces chronic cardiopathy resembling IFN-gamma was...
Abstract Objectives The cellular therapy using adipose‐derived mesenchymal stem cells (ASCs) aims to improve tendon healing, considering that repaired tendons often result in a less resistant tissue. Our objective was evaluate the effects of ASCs combination with low‐level laser (LLL), an effective photobiostimulation for healing processes. Materials and methods Rats calcaneal were divided into five groups: normal (NT), transected (T), (SC) or LLL (L), (SCL). Results All treated groups...
Green tea (GT) has been consumed as a beverage for thousands of years because its therapeutic properties observed over time. Because there is no sufficient evidence supporting the protective role intake during development acute myeloid leukaemia, we herein study GT extract effects on an promyelocytic leukaemia model. Our results demonstrated that reduces leucocytosis and immature cells (blasts) in peripheral blood, bone marrow (BM), spleen leukaemic mice, parallel with increase mature BM. In...
Abstract Peripheral nerve injuries severely impair patients’ quality of life as full recovery is seldom achieved. Upon axonal disruption, the distal stump undergoes fragmentation, and myelin breaks down; subsequent regeneration progression dependent on cell debris removal. In addition to tissue clearance, macrophages release angiogenic neurotrophic factors that contribute axon growth. Based importance for regeneration, especially during initial response injury, we treated mice with...
Major histocompatibility complex class one (MHC-I) antigen-presenting molecules participate in central nervous system (CNS) synaptic plasticity, as does the paired immunoglobulin-like receptor B (PirB), an MHC-I ligand that can inhibit immune-cells and bind to myelin axon growth inhibitors. Based on dual roles of both immune systems, we evaluated their expression peripheral (PNS) following sciatic nerve injury mice. Increased PirB protein gene is present spinal cord week after transection,...
Chagas' disease is a protozoosis caused by Trypanosoma cruzi that frequently shows severe chronic clinical complications of the heart or digestive system. Neurological disorders due to T. infection are also described in children and immunosuppressed hosts. We have previously reported IL-12p40 knockout (KO) mice infected with strain Sylvio X10/4 develop spinal cord neurodegenerative disease. Here, we further characterized neuropathology, parasite burden inflammatory component associated fatal...
<i>Background/Aim:</i> Chagas’ disease is caused by <i>Trypanosoma cruzi</i> and occurs in most Latin American countries. The protozoan may colonize the central nervous system (CNS) of immune-compromised human hosts, thus causing neuronal disorders. Systemic control intracellular forms parasite greatly depends on establishment a TH1 response subsequent nitric oxide (NO) release. At CNS, it known that low concentrations NO promote survival growth, while high exert...
The thymus plays an important role shaping the T cell repertoire in periphery, partly, through elimination of inflammatory auto-reactive cells. It has been shown that, during Plasmodium berghei infection, is rendered atrophic by premature egress CD4+CD8+ double-positive (DP) cells to periphery. To investigate whether autoimmune diseases are affected after NK65 we immunized C57BL/6 mice, which was previously infected with P. and treated chloroquine (CQ), MOG35-55 peptide clinical course...
The early migratory phase of pulmonary helminth infections is characterized by tissue injury leading to the release alarmin interleukin (IL)-33 and subsequent induction type 2 immune responses. We recently described a role for IL-17A, through suppression interferon (IFN)-γ, as an important inducer responses during infection with lung-migrating rodent nematode Nippostrongylus brasiliensis. Here, we aimed investigate interaction between IL-17A IL-33 lung stages N. brasiliensis infection. In...
Abstract Immunomodulation has been considered an important approach in the treatment of malignant tumours. However, modulation innate immune cells remains underexplored tool. Studies from our group demonstrated that Phoneutria nigriventer spider venom (PnV) administration increased infiltration macrophage glioblastoma, addition to decreasing tumour size a preclinical model. The hypothesis PnV would be modulating system led us main objective present study: elucidate effects and its purified...
Chagas disease is a Trypanosoma cruzi-induced zoonosis that has no natural cure. Local damage induced by the parasite and immune response causes chronic heart digestive lesions. Efforts to develop therapeutic vaccine boosts completely clear are needed because there effective treatment for chronically infected patients. In an attempt modify host-parasite equilibrium increase destruction, we analyzed cardiopathy in mice were challenged with live homologous parasites. Challenge single dose of...
The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects close association between nervous and immune systems. In turn, MHC-I upregulation postinjury is associated with a better regenerative outcome in isogenic mice following peripheral nerve damage. present work, we compared time course neuronal, glial, sensorimotor recovery (1, 3, 5, 7, 28 days after lesion—dal) unilateral sciatic crush A/J C57BL/6J mice. strain showed higher expression (7 dal, ** p < 0.01),...