A5044078596- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Hematopoietic Stem Cell Transplantation
- Algal biology and biofuel production
- Immune cells in cancer
- Medicinal Plants and Bioactive Compounds
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Therapeutic Uses of Natural Elements
- Mesenchymal stem cell research
- Occupational and environmental lung diseases
- Antioxidants, Aging, Portulaca oleracea
- Cancer-related Molecular Pathways
- Tea Polyphenols and Effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Complementary and Alternative Medicine Studies
- Heavy Metal Exposure and Toxicity
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Lymphatic System and Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Essential Oils and Antimicrobial Activity
- Chemokine receptors and signaling
- Cerebrovascular and Carotid Artery Diseases
- Antimicrobial agents and applications
Universidade Estadual de Campinas (UNICAMP)
2014-2023
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2017
In the present study, we investigated molecular mechanisms underlying pro-apoptotic effects of quercetin (Qu) by evaluating effect Qu treatment on DNA methylation and posttranslational histone modifications genes related to apoptosis pathway. This study was performed in vivo two human xenograft acute myeloid leukemia (AML) models vitro using HL60 U937 cell lines. almost eliminates DNMT1 DNMT3a expression, this regulation part STAT-3 dependent. The also downregulated class I HDACs....
Abstract (–)-Epigallocatechin-3-gallate (EGCG), the major active polyphenol extracted from green tea, has been shown to induce apoptosis and inhibit cell proliferation, invasion, angiogenesis metastasis. Herein, we evaluated in vivo effects of EGCG acute myeloid leukaemia (AML) using an promyelocytic (APL) experimental model (PML/RARα). Haematological analysis revealed that treatment reversed leucocytosis, anaemia thrombocytopenia, prolonged survival PML/RARα mice. Notably, reduced immature...
We studied the effects of Chlorella vulgaris (CV) on interaction between stromal and hematopoietic stem cells in normal Ehrlich ascites tumor (EAT)-bearing mice. Long-term bone marrow culture (LTBMC), cytokine production, spleen mononuclear (SMC) proliferation (SCP), colony stimulating activity (CSA), NK were evaluated. In bearers, reduced capacity cell layer to support growth differentiation granulocyte-macrophage progenitor (CFU-GM), concomitantly decreased numbers total nonadherent LTBMC...
Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) numbers of marrow hematopoietic stem cells (HSCs) (c-Kit(+)Lin(-)), granulocyte-macrophage progenitors (Gr1(+)Mac1(+)) and total bone cellularity. In mice gavage-treated daily with 50mg/kg dose CV 10 days, concomitant to a continuous offering 1300 ppm acetate in drinking water, treatment algae recovered significantly reduced these cell populations control values. As may have myelostimulating...
Green tea (GT) has been consumed as a beverage for thousands of years because its therapeutic properties observed over time. Because there is no sufficient evidence supporting the protective role intake during development acute myeloid leukaemia, we herein study GT extract effects on an promyelocytic leukaemia model. Our results demonstrated that reduces leucocytosis and immature cells (blasts) in peripheral blood, bone marrow (BM), spleen leukaemic mice, parallel with increase mature BM. In...
Green tea (GT) treatment was evaluated for its effect on the immune and antineoplastic response of elderly acute myeloid leukemia patients with myelodysplasia-related changes (AML-MRC) who are ineligible aggressive chemotherapy bone marrow transplants. The eligible enrolled in study (n = 10) received oral doses GT extract (1000 mg/day) alone or combined low-dose cytarabine at least 6 months and/or until progression. Bone (BM) peripheral blood (PB) were monthly. Median survival increased as...
In this study, Balb/C mice received standard or high-fat diet (HFD) and were treated with Chlorella for 5 days prior 4 weeks after the onset of HFD. Our findings demonstrate that in HFD-induced obesity, there is a rapid decline number granulocyte macrophage progenitors (CFU-GM) bone marrow, which associated continuous migration/increase these cells into spleen, process characterized as extramedullary hematopoiesis (EMH). No changes size primitive (LSK), reduction granulocyte/macrophage (GMP)...
The long-term effects of Chlorella doses on the inflammatory status and quality life (QoL) individuals with type-2 diabetes (T2D), prediabetes (pre-T2D), nondiabetic controls were investigated. was administered for 12 months; 1.6 g/day first six months 3 following months. profile studied by quantification cytokines, adipokines incretins. QoL evaluated using Short Form-36 health survey questionnaire (SF-36). Evaluations performed at baseline, 6 (T6) (T12) after initiating intake. At more...
The effects of a dry extract the roots Angelica sinensis (Oliv.) Diels (ASE) on growth and differentiation granulocyte-macrophage progenitor cells (CFU-GM) in normal Listeria monocytogenes-infected mice were studied. Myelosuppression concomitant with increased numbers spleen CFU-GM was observed infected mice. Prophylactic administration ASE (10, 25, 50 mg/kg) stimulated marrow myelopoiesis dose-dependent manner reduced colony formation to control values. dose mg/kg optimal biologically...
Most of the cosmetic compounds with preservative properties available in market pose some risks concerning safety, such as possibility causing sensitization. Due to fact that there are few options, proper development new molecules this purpose is needed. Xylitol a natural sugar, and antimicrobial xylitol-derived have already been described literature. C-8 xylitol monoester phosphate esters may be useful for skincare products. As an initial screen safety chemicals, combination silico methods...
ARHGAP21 is a member of the RhoGAP family proteins involved in cell growth, differentiation, and adhesion. We have previously shown that heterozygous Arhgap21 knockout mouse model (Arhgap21+/-) presents several alterations hematopoietic compartment, including increased frequency stem progenitor cells (HSPC) with impaired adhesion vitro, mobilization to peripheral blood, decreased engraftment after bone marrow transplantation. Although these HSPC functions strongly depend on their...