A5035591537- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Sesquiterpenes and Asteraceae Studies
- Insect Pest Control Strategies
- Phytochemistry and Biological Activities
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Alkaloids: synthesis and pharmacology
- Trypanosoma species research and implications
- Malaria Research and Control
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Bioactive Compounds
- Morinda citrifolia extract uses
- Synthesis of Organic Compounds
- Chemical synthesis and alkaloids
- Plant-derived Lignans Synthesis and Bioactivity
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Research on Leishmaniasis Studies
Universidade Federal de Minas Gerais
2015-2024
Pontifícia Universidade Católica de Minas Gerais
2024
Universidade Federal do Pará
2014-2023
Universidade Federal do Oeste do Pará
2023
Southwest Bahia State University
2023
Instituto de Ciências Farmacêuticas
1997-2012
Universidad de Salamanca
2003-2007
Ezequiel Dias Foundation
2005
Curtin University
2003
Prefeitura Municipal de Belo Horizonte
2002
Abstract Pretreatment of rats with hesperidin (50 and 100 mg kg−1, s.c.) reduced the paw oedema induced by carrageenan 47 63%, respectively, within 5 h. The effect was equivalent to that produced indomethacin (10 p.o.), although unrelated administered dose, particularly at high doses. At kg−1 decreased rat dextran 33%, without influencing histamine-induced oedema. Hesperidin also inhibited pleurisy carrageenan, reducing volume exudate number migrating leucocytes 48 34%, control values. Equal...
Ethanol extracts of 83 plants species belonging to the Asteraceae (Compositae) family, collected in State Minas Gerais, Brazil, were tested for larvicidal activity against mosquito Aedes fluviatilis - Diptera: Culicidae). The extract from Tagetes minuta was most active with a LC90 1.5 mg/l and LC50 1.0 mg/l. This plant has been object several studies by other groups its components have already identified as thiophene derivatives, class compounds present many species. Eclipta paniculata also...
Aqueous infusions of Brazilian Maytenus leaves are used as beverages, foodstuffs, and phytomedicines. Previously, we isolated two new flavonoid tetrasaccharides from the infusion aquifolium that showed antiulcer activity. In this investigation a tetrasaccharide, kaempferol-3-O-α-l-rhamnopyranosyl (1→6)-O-[α-l-arabinopyranosyl (1→3)-O-α-l-rhamnopyranosyl (1→2)]-O-β-d-galactopyranoside (3), was isolated, together with kaempferol tri- disaccharides quercetin trisaccharides aqueous ilicifolia...
Ethanol extract from Arrabidaea triplinervia leaves showed in vitro activity (ED100 5.0 mg/ml) against trypomastigotes of Trypanosoma cruzi, the etiologic agent Chagas; disease. Bioactivity-directed fractionation this led to isolation ursolic and oleanolic acids as trypanocidal compounds besides pomolic acid (not tested) alpinetine (inactive). A series natural synthetic derivatives was simultaneously assayed for structure relationships (SAR) studies. Ursolic 0.4 four times more active than...
To investigate the in vitro antiviral activity of Distictella elongata (Vahl) Urb. ethanol extracts from leaves (LEE), fruits (FEE), stems and their main components.The was evaluated against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), vaccinia Western Reserve (VACV-WR) dengue 2 (DENV-2) by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. LEE presented anti-HSV-1 [EC(50) 142.8 ± 5.3 μg ml(-1); selectivity index (SI) 2.0]...
The essential oil of molasses grass (Melinis minutiflora Beauv.) has shown virtually 100% lethal effect on larvae the cattle-tick (Boophilus microplus) within 10 min exposure. GC/MS analysis led to identification six major components: propionic acid, butyric phenylethyl alcohol, hexanal, 1,8-cineole and 9 -E-eicosene. Two those components (1,8-cineole n-hexanal) have also individually min. presence 2,6-di-t-butyl-4-methylphenol was assigned a contaminant from commercially supplied diethyl...
The bioguided fractionation of the crude extracts Lychnophora passerina (Mart. ex DC) Gardn., L. pinaster Mart. and trichocarpha Spreng. led to isolation four compounds active against trypomastigote forms Trypanosoma cruzi: sesquiterpene lactones goyazensolide (1), eremantholide C (2), lychnopholide (3) a new caryophyllene derivative, which was named lychnophoic acid (4).
The aim of the present work was to carry out a bioguided isolation antiviral chemical constituents from an ethanol extract leaves Arrabidaea pulchra (Cham.) Sandwith (EEAPL) that had shown in vitro activity previous screening using DNA and RNA viruses. EEPAL evaluated against viruses Human herpesvirus 1 (HSV-1) Vaccinia virus Western Reserve (VACV-WR) as well Murine encephalomyocarditis (EMCV), Dengue 2 (DENV-2) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...