A5032214339- Natural product bioactivities and synthesis
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactive Compounds
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Phytochemical Studies and Bioactivities
- Biological Activity of Diterpenoids and Biflavonoids
- Pharmacology and Obesity Treatment
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Seaweed-derived Bioactive Compounds
- Steroid Chemistry and Biochemistry
- Hormonal Regulation and Hypertension
- Helminth infection and control
- Insect Pest Control Strategies
- Phytochemicals and Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- Plant Toxicity and Pharmacological Properties
Universidade Federal de Minas Gerais
2016-2025
Center for Rheumatology
2014
University of Hawaii at Hilo
2008
Prefeitura Municipal de Belo Horizonte
2002
The leaves of Hancornia speciosa Gomes are traditionally used to treat diabetes in Brazil. aim the study is evaluate potential anti-diabetic effect extract and derived fractions.The ethanolic from chromatographic fractions thereof were evaluated on α-glucosidase assay, hyperglycemic glucose uptake. chemical composition its most active fraction was investigated by ESI-LC-MS.The inhibited vitro. However, only crude dichloromethane induced starch or glucose. Both also able increase uptake...
Cardiac glycosides, known ligands of the sodium pump, are widely used in treatment heart failure, such as digoxin and digitoxin. Besides this important activity, other biological activities, antiviral have been described for group. HSV responsible many infections oral, ocular genital regions. Treatment with nucleoside analogs acyclovir is effective most cases; however drug-resistance may arise due to prolonged mainly immunocompromised individuals. In study, an antiherpes screening was...
The leaves of Hancornia speciosa Gomes are popularly used in Brazil to treat diabetes and hypertension. Cardiovascular diseases the main cause death worldwide their incidences increasing Brazilian population. present study aimed investigate hypotensive effect mechanism action Gomes. A fraction ethanolic extract from (SFH) was obtained standardized by its content on rutin, bornesitol quinic acid. Systolic blood pressure (SBP) normotensive mice measured tail pletismography. SFH given orally...
Cancer is one of the leading causes death worldwide. Although several drugs are used clinically, some tumors either do not respond or resistant to existing pharmacotherapy, thus justifying search for new drugs. Ursolic acid (UA) a triterpene found in different plant species that has been shown possess significant antitumor activity. However, UA presents low solubility aqueous medium, which barrier its biological applications. In this context, use liposomes promising strategy deliver and...
ABSTRACT Severe coronavirus outbreaks, including SARS, MERS, and COVID‐19, have underscored the urgent need for effective antiviral therapies. This study evaluated activity of biflavanones isolated from Ouratea spectabilis —specifically ouratein (Our‐) A, B, C, D—against murine hepatitis virus (MHV‐3) human SARS‐CoV‐2. Cells infected with MHV‐3 or SARS‐CoV‐2 were treated ourateins, viral replication was assessed using plaque assays. Mice Our‐D either orally intraperitoneally. Key assessments...
Stryphnodendron species, popularly named "barbatimão," are traditionally used in Brazil as anti-inflammatory agents. This study aimed to investigate the effect of barbatimão and 11 other species on production tumor necrosis factor-alpha (TNF-α) lipopolysaccharide- (LPS-) stimulated THP-1 cells, well their anti-arthritis activity. The extracts adstringens, obovatum, Campomanesia lineatifolia, Terminalia glabrescens promoted a concentration-dependent inhibition TNF-α. Mice injected with LPS...
Paullinia cupana is a plant native to Brazil that widely used in traditional medicine as physical and mental stimulant. It also worldwide produce soft drinks. A method for the simultaneous quantitation of seven markers guaraná by HPLC-PDA was developed, extraction methods determination methylxanthines tannins were investigated. Quantified substances theobromine, theophylline, caffeine, catechin, epicatechin, procyanidins A2 B2. Results confirmed satisfactory selectivity linearity (r2≥0.99)...
The aerial parts of Cuphea carthagenensis (Jacq.) J.F. Macbride (Lythraceae) are traditionally employed in Brazil to treat cardiovascular diseases. aim this study was compare preparations C. (aqueous and ethanol extracts, together with derived fractions) regard their total phenolic contents vitro vasodilating activity. main flavonoids found the extracts were isolated identified as quercetin derivatives. fractions showed similar HPLC profiles presence quercetin-5-O-β-glucopyranoside,...
The leaves of Hancornia speciosa Gomes (Apocynaceae), a medicinal species found in the Brazilian cerrado biome, are traditionally used to treat wounds and inflammatory disorders. goal present study was investigate vitro wound healing properties ethanolic extract H. its isolated compounds, using scratch assay, evaluate their effects on release pro-inflammatory cytokine tumor necrosis factor (TNF-α) by lipopolysaccharide (LPS)-stimulated human acute monocytic (THP-1) cells. significantly...
Cardiac glycosides (CGs) are natural compounds used traditionally to treat congestive heart diseases. Recent investigations repositioned CGs as potential anticancer agents. To discover novel cytotoxic CG scaffolds, we selected the cardenolide glucoevatromonoside (GEV) out of 46 for its low nanomolar anti-lung cancer activity. GEV presented reduced toxicity towards non-cancerous cell types (lung MRC-5 and PBMC) high-affinity binding Na+/K+-ATPase alpha subunit, assessed by computational...
To investigate the anti‐HSV and anti‐inflammatory effects of a standardized ethyl acetate extract (SEAE) prepared with stem bark Strychnos pseudoquina, along two isolated compounds: quercetin 3‐O‐methyl ether (3MQ) strychnobiflavone (SBF). The mechanisms action were evaluated by different methodological strategies. SEAE SBF affected early stages viral infection reduced HSV‐1 protein expression. Both flavonoids elicited concentration‐dependent inhibition monocyte chemoattractant protein‐1...