A5062001402- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Research on Leishmaniasis Studies
- Phytochemistry and Biological Activities
- Agricultural and Food Sciences
- Insect Pest Control Strategies
- Phytochemistry and Bioactive Compounds
- Plant biochemistry and biosynthesis
- Bee Products Chemical Analysis
- Ocular Surface and Contact Lens
- Advanced Drug Delivery Systems
- Phytochemical compounds biological activities
- Glaucoma and retinal disorders
- Psidium guajava Extracts and Applications
- Computational Drug Discovery Methods
- Phytochemistry and biological activity of medicinal plants
- Botanical Research and Applications
- Pharmacogenetics and Drug Metabolism
- Sesquiterpenes and Asteraceae Studies
- Natural Antidiabetic Agents Studies
- Plant Diversity and Evolution
- Phytochemistry and Bioactivity Studies
- Coffee research and impacts
Universidade Federal de Minas Gerais
2015-2024
ORCID
2019
Universidade Católica Dom Bosco
2004-2006
Universidade Federal do Rio de Janeiro
1999-2005
Dental caries is the most prevalent oral disease in several Asian and Latin American countries. It an infectious different types of bacteria are involved process. Synthetic antimicrobials used against this disease; however, many these substances cause unwarranted undesirable effects like vomiting, diarrhea tooth staining. Propolis, a resinous substance collected by honeybees, has been to control microbiota. So, objective study was develop characterize sustained-release propolis-based...
Different solvents were evaluated for the extraction of jabuticaba anthocyanin pigments, identifying, quantifying and verifying stability anthocyanins, as well conduction three antioxidant activity assays determination vitamin C levels. The maceration with ethanol acidified HCl 1.5 mol L-1 (85:15) provides better pigment stability. skin is rich, presenting 1.59 2.06 g 100 g-1 dry matter in Paulista Sabará varieties, respectively. Cyanidin 3-glucoside majority skins, followed by delphinidin...
Abstract: The study reported here aimed to develop an optimized nanoparticle delivery system for amphotericin B (AmpB) using a polyelectrolyte complexation technique. For this, two oppositely charged polymers presenting anti-leishmanial activity – chitosan (Cs) and chondroitin sulfate (ChS) were used: Cs as positively polymer ChS negatively polymer. (NQ) nanoparticles, chitosan-chondroitin (NQC) sulfate-amphotericin (NQC-AmpB) nanoparticles presented mean particle size of 79, 104, 136 nm,...
The purpose of the present study was to develop and assess a novel sustained-release drug delivery system Bimatoprost (BIM). Chitosan polymeric inserts were prepared using solvent casting method characterized by swelling studies, infrared spectroscopy, differential scanning calorimetry, content, electron microscopy in vitro release. Biodistribution 99mTc-BIM eye drops 99mTc-BIM-loaded inserts, after ocular administration Wistar rats, accessed ex vivo radiation counting. evaluated for their...
Eye drops containing hydrophilic drugs are commonly used to reduce intraocular pressure (IOP) in glaucoma patients, but compliance the treatement is reduced by frequent dosing and eventual systemic side effects. Sustained-release drug delivery systems, such as ocular inserts, can dosing, limit exposure, effects, and, then, improve patient adherence therapy. Here, we developed evaluated chitosan/hydroxyethyl cellulose-based inserts for sustained release of dorzolamide, a drug. Dorzolamide...
Abstract: Amphotericin B (AmpB) is active against leishmaniasis, but its use hampered due to high toxicity observed in patients. In this study, a nanoparticles-delivery system for AmpB (NQC-AmpB), containing chitosan and chondroitin sulfate molecules, was evaluated BALB/c mice Leishmania amazonensis . An vivo biodistribution including biochemical toxicological evaluations, performed evaluate the of AmpB. Nanoparticles were radiolabeled with technetium-99m injected mice. The products...
To investigate the in vitro antiviral activity of Distictella elongata (Vahl) Urb. ethanol extracts from leaves (LEE), fruits (FEE), stems and their main components.The was evaluated against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), vaccinia Western Reserve (VACV-WR) dengue 2 (DENV-2) by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. LEE presented anti-HSV-1 [EC(50) 142.8 ± 5.3 μg ml(-1); selectivity index (SI) 2.0]...
The purpose of this study was to screen the antioxidant activity medicinal plant extracts from Brazilian cerrado, through other methods than total phenolic content and its correlation with activity. Ethanolic ten species were evaluated three assays, in vitro, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power; by using Folin-Ciocalteu method determined. Stryphnodendron obovatum, Cecropia pachystachya Duguetia furfuraceae showed strong (IC50<5 µg mL-1) DPPH free radical...
Stryphnodendron species, popularly named "barbatimão," are traditionally used in Brazil as anti-inflammatory agents. This study aimed to investigate the effect of barbatimão and 11 other species on production tumor necrosis factor-alpha (TNF-α) lipopolysaccharide- (LPS-) stimulated THP-1 cells, well their anti-arthritis activity. The extracts adstringens, obovatum, Campomanesia lineatifolia, Terminalia glabrescens promoted a concentration-dependent inhibition TNF-α. Mice injected with LPS...
Paullinia cupana is a plant native to Brazil that widely used in traditional medicine as physical and mental stimulant. It also worldwide produce soft drinks. A method for the simultaneous quantitation of seven markers guaraná by HPLC-PDA was developed, extraction methods determination methylxanthines tannins were investigated. Quantified substances theobromine, theophylline, caffeine, catechin, epicatechin, procyanidins A2 B2. Results confirmed satisfactory selectivity linearity (r2≥0.99)...
This ethnobotanical survey carried out with the Kaiowá and Guarani populations in Caarapó Reserve (Mato Grosso do Sul, Brazil) showed that 34 plant species of 22 families medicinal properties, are used for treating diverse pathologies. Local names Portuguese provided, along therapeutic indications, modes preparation, a description parts used. These folk-medicine plants have been mostly treatment influenza, abdominal pain, fever rheumatism, wound healing.
Chemoinformatics is an independent inter-discipline with a broad impact in drug design and discovery, medicinal chemistry, biochemistry, analytical organic natural products, several other areas chemistry. Through collaborations, scientific exchanges, participation international research networks, Latin American scientists have contributed to the development of this subject. The aim perspective discuss status progress chemoinformatic discipline America. We team up provide author´s on topics...
O objetivo do presente trabalho foi realizar um levantamento etnofarmacológico das principais espécies vegetais comercializadas no Mercado Municipal de Campo Grande (MS). estudo realizado entre agosto 2002 e 2003, através entrevistas com os raizeiros. Cerca 117 foram citadas. Foram selecionadas as plantas dos biomas Cerrado Pantanal dessas 34 adquiridas. Das adquiridas 22 identificadas botanicamente, pois o material outras deficiente para determinação até espécie. identifificadas, somente...