A5101496267- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Renin-Angiotensin System Studies
- Advanced Drug Delivery Systems
- Neuropeptides and Animal Physiology
- Retinal Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Heavy Metal Exposure and Toxicity
- Bone Tissue Engineering Materials
- Mercury impact and mitigation studies
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Trypanosoma species research and implications
- Proteoglycans and glycosaminoglycans research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Amoebic Infections and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pulmonary Hypertension Research and Treatments
- Retinopathy of Prematurity Studies
- Paraoxonase enzyme and polymorphisms
- Sodium Intake and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Corneal Surgery and Treatments
- Pregnancy and preeclampsia studies
Universidade Tecnológica Federal do Paraná
2024
Universidade Federal de Minas Gerais
2012-2021
Universidade Federal do Rio Grande do Norte
2020
Excess intake of sodium is often associated with high risk for cardiovascular disease. More recently, some studies on the effects salt diets have also demonstrated that they are able to activate Th17 cells and increase severity autoimmune diseases. The purpose present study was evaluate a diet supplemented NaCl in colonic mucosa at steady state during inflammation. We showed consumption (HSD) by mice triggered gut inflammatory reaction IL-23 production, recruitment neutrophils increased...
ABSTRACT Zika virus (ZIKV) infection is a global health emergency that causes significant neurodegeneration. Neurodegenerative processes may be exacerbated by N -methyl- d -aspartate receptor (NMDAR)-dependent neuronal excitoxicity. Here, we have exploited the hypothesis ZIKV-induced neurodegeneration can rescued blocking NMDA overstimulation with memantine. Our results show ZIKV actively replicates in primary neurons and replication directly associated massive cell death. Interestingly,...
The purpose of the present study was to develop and assess a novel sustained-release drug delivery system Bimatoprost (BIM). Chitosan polymeric inserts were prepared using solvent casting method characterized by swelling studies, infrared spectroscopy, differential scanning calorimetry, content, electron microscopy in vitro release. Biodistribution 99mTc-BIM eye drops 99mTc-BIM-loaded inserts, after ocular administration Wistar rats, accessed ex vivo radiation counting. evaluated for their...
This study evaluated the effects of hyaluronic acid (HA) on bone repair human dental sockets. Thirty-two lower first premolars were extracted from 16 patients (2 per patient) for orthodontic reasons. Following extractions, one socket was randomly filled with 1% HA gel, while other allowed to naturally fill blood clot. After 30 and 90 days surgery, underwent cone beam computed tomography. Five central orthoradial slices captured each socket. The gray intensity measured in image results...
Eye drops containing hydrophilic drugs are commonly used to reduce intraocular pressure (IOP) in glaucoma patients, but compliance the treatement is reduced by frequent dosing and eventual systemic side effects. Sustained-release drug delivery systems, such as ocular inserts, can dosing, limit exposure, effects, and, then, improve patient adherence therapy. Here, we developed evaluated chitosan/hydroxyethyl cellulose-based inserts for sustained release of dorzolamide, a drug. Dorzolamide...
Purpose.: To evaluate the effects of activation endogenous angiotensin-converting enzyme 2 (ACE2) using compound diminazene aceturate (DIZE) in an experimental model glaucoma Wistar rats. Methods.: DIZE (1 mg/kg) was administered daily, either systemically or topically, and IOP measured weekly. examine role Mas receptor DIZE, Ang-(1-7) antagonist A-779 co-administered. Drainage aqueous humor evaluated by scintigraphy. The analysis ACE2 expression immunohistochemistry counting retinal...
Background and Aims: Recent studies have proposed that if a severe caloric restriction (SCR) is initiated at the earliest period of postnatal life, it can lead to beneficial cardiac adaptations later on. We investigated effects SCR in Wistar rats from birth adult age on risk factors for diseases (CD), as well function, redox status HSP72 content response ischemia/reperfusion (I/R) injury. Methods Results: From 3 months, CR50 were fed 50% food ad libitum group (AL) was fed. Food intake...
The aim of this study was to develop and evaluate the effects chitosan inserts for sustained release angiotensin-converting enzyme 2 (ACE2) activator, diminazene aceturate (DIZE), in experimental glaucoma. Monolayer DIZE loaded (D+I) were prepared characterized through swelling, attenuated total reflectance Fourier transformed infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) vitro drug release. Functionally, D+I tested glaucomatous rats. Glaucoma induced by weekly...
Diabetic retinopathy (DR) is a serious complication of diabetes mellitus that may result in blindness. We evaluated the effects activation endogenous angiotensin converting enzyme (ACE) 2 on early stages DR. Rats were administered an intravenous injection streptozotocin to induce hyperglycemia. The ACE2 activator 1-[[2-(dimethylamino) ethyl] amino]-4-(hydroxymethyl)-7-[[(4-methylphenyl) sulfonyl] oxy]-9H-xanthone 9 (XNT) was by daily gavage. death retinal ganglion cells (RGC) histological...
Human amoebiasis is caused by the parasitic protozoan Entamoeba histolytica that lives in large intestine of hosts, where can produce asymptomatic colonization until severe invasive infections with blood diarrhea and spreading to other organs. The amoebic abscesses liver are most frequent form outside still there doubts about pathogenic mechanisms involved their formation. In this study we evaluated situ binding antibodies, C3 C9 complement components on trophozoites, livers hamsters...
To propose an alternative model of hepatic encephalopathy (HE) in mice, resembling the human features disease.Mice received two consecutive intraperitoneal injections thioacetamide (TAA) at low dosage (300 mg/kg). Liver injury was assessed by serum transaminase levels (ALT) and liver histology (hematoxylin eosin). Neutrophil infiltration estimated confocal intravital microscopy. Coagulopathy evaluated using prolonged prothrombin partial thromboplastin time. Hemodynamic parameters were...
Abstract The use of chitosan as a pharmaceutical excipient in the ocular field is already established. Nevertheless, some aspects related to its administration, such sterilization and excipient's pharmacokinetics, remain unclear. So, this study, we evaluated those two relevant aspects, administration eye. We used chitosan‐based inserts (CI) formulation model. CI were produced by solvent/casting method sterilized saturated steam. Sterilization was confirmed direct inoculation suitable...
Purpose: The aim of this work was to study the optimum conditions for production sclerotiorin, a highly active secondary metabolite Penicillium sclerotiorum under different cultural media. Methods: A Brazilian strain P. grown culture in two liquid media (malt and dextrose-peptone salt medium supplemented with sodium chloride) solid state fermentation rice. Sclerotiorin monitored by high performance chromatography (HPLC). Results: Quantitative analysis sclerotiorin content HPLC indicated that...
The prevalence of food allergy is rising in the western world. Allergen restriction chosen treatment this condition, but continuous ingestion antigen has shown positive results clinical trials. In a previous study, we have several allergic and metabolic alterations after 7 days ovalbumin (OVA) by sensitized mice. aim study was to investigate whether prolonged mice would reverse consequences caused experimental allergy. For this, parameters were analysed an OVA diet OVA-sensitized As...
Knee osteoarthritis (kOA) is a common chronic disease that induces changes in redox status and inflammatory biomarkers, cell death, motor impairment. Aerobic training can be non-pharmacological alternative to prevent the progression of disease.To evaluate effects an 8 weeks moderate-intensity treadmill aerobic program on biomarkers performance kOA-like induced by monosodium iodoacetate (MIA) rats.Twenty-seven rats were randomly divided into three groups: SHAM; kOA (OA); + (OAE). Motor was...
Pre- and postnatal protein deficiency may lead to decreased foetal intra-uterine development growth, which is common in developing countries. The present study aimed investigate the consequences of a low-protein intake during gestation postnatally on adult female rats' offspring. Female rats were given either control or protein-deficient diet throughout lactation periods. A subset females was killed at day 20 pregnancy for placental measurements. Another farrowed number, length, weight...
The most common treatment for Primary Open-Angle Glaucoma (POAG) is the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve patient adherence by achieving prolonged therapeutic concentrations in ocular target tissues while limiting systemic exposure. purpose this study compare efficacy and safety bimatoprost inserts with drops patients POAG Ocular Hypertension (OH).We include OH aged between 40 75 years-old. Both had intraocular pressure (IOP)...