A5054156788- Nitric Oxide and Endothelin Effects
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Celiac Disease Research and Management
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Antioxidant Activity and Oxidative Stress
- Pain Mechanisms and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Electron Spin Resonance Studies
- Cardiac electrophysiology and arrhythmias
- Cannabis and Cannabinoid Research
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Blood Coagulation and Thrombosis Mechanisms
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Microscopic Colitis
- Ion Channels and Receptors
- Seaweed-derived Bioactive Compounds
- Paraquat toxicity studies and treatments
- Apelin-related biomedical research
Universidade Federal de Minas Gerais
2015-2024
University of California, San Diego
2020-2022
École Polytechnique Fédérale de Lausanne
2011-2014
Czech Academy of Sciences, Institute of Physiology
2010
Neuroinflammation is a major component in the transition to and perpetuation of neuropathic pain states. Spinal neuroinflammation involves activation TLR4, localized enlarged, cholesterol-enriched lipid rafts, designated here as inflammarafts. Conditional deletion cholesterol transporters ABCA1 ABCG1 microglia, leading inflammaraft formation, induced tactile allodynia naive mice. The apoA-I binding protein (AIBP) facilitated depletion from inflammarafts reversed model chemotherapy-induced...
Thiamine is an important cofactor of metabolic enzymes, and its deficiency leads to cardiovascular dysfunction. First, we characterized the status measuring resting oxygen consumption rate lactate blood concentration after 35 days thiamine (TD). The results pointed a decrease in twofold increase lactate. Confocal microscopy showed that intracellular superoxide (∼40%) H 2 O (2.5 times) contents had been increased. In addition, biochemical activities protein expression SOD, glutathione...
AimsThe activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression endocannabinoid system in human carotid plaques and impact CB2 pharmacological on markers plaque vulnerability vivo vitro.
Endothelium-dependent vasorelaxation in large vessels is mainly attributed to Nomega-nitro-L-arginine methyl ester (L-NAME)-sensitive endothelial nitric oxide (NO) synthase (eNOS)-derived NO production. Endothelium-derived hyperpolarizing factor (EDHF) the component of endothelium-dependent relaxations that resists full blockade synthases (NOS) and cyclooxygenases. H2O2 has been proposed as an EDHF resistance vessels. In this work we propose mice aorta neuronal (n)NOS-derived accounts for a...
In large vessels, endothelium-dependent vasodilation is mainly attributed to endothelial nitric oxide synthase (eNOS)-derived NO production. However, we have recently shown that neuronal (nNOS)-derived H(2)O(2) also an relaxing factor in the mouse aorta. The relative contribution of nNOS/eNOS, H(2)O(2)/NO remains be characterized. This work was undertaken determine versus H(2)O(2), and eNOS nNOS We used carbon microsensors placed next lumen vessels simultaneously measure NO, vascular tone....
Reduced NO availability has been described as a key mechanism responsible for endothelial dysfunction in atherosclerosis. We previously reported that neuronal NOS (nNOS)-derived H(2)O(2) is an important endothelium-derived relaxant factor the mouse aorta. The role of and nNOS atherosclerosis remains undetermined. hypothesized decrease nNOS-derived contributes to impaired vasodilatation apolipoprotein E-deficient mice (ApoE(-/-)).Changes isometric tension were recorded on myograph;...
Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here, we investigated the potential benefits of CXC chemokine-binding protein Evasin-3, which potently inhibits chemokine bioactivity related neutrophilic two mouse models atherosclerosis stroke, respectively. In first model, chronic treatment with Evasin-3 as compared Vehicle (phosphate-buffered saline (PBS)) was apolipoprotein E-deficient mice implanted 'cast' device....
Summary Angiotensin (Ang)-(1–7), acting through the receptor Mas, has atheroprotective effects; however, its role on plaque vulnerability been poorly studied. Here, we investigated expression of renin-angiotensin system (RAS) components in stable and unstable human carotid plaques. In addition, evaluated effects chronic treatment with an oral formulation Ang-(1–7) a mouse model shear stress-determined atherosclerotic plaque. Upstream downstream regions internal plaques were obtained from...
Nociceptive afferent signaling evoked by inflammation and nerve injury is mediated the opening of ligand-gated voltage-gated receptors or channels localized to cholesterol-rich lipid raft membrane domains. Dorsal root ganglion (DRG) nociceptors express high levels toll-like receptor 4 (TLR4), which also localize rafts. Genetic deletion pharmacologic blocking TLR4 diminishes pain associated with chemotherapy-induced peripheral neuropathy (CIPN). In DRGs mice paclitaxel-induced CIPN, we...
The aim of the present study was to evaluate Ca2+ handling and contractility properties cardiomyocytes isolated from rats with high intrinsic aerobic exercise capacity. Standard-performance (SP) high-performance (HP) were categorized a treadmill progressive test according time fatigue (TTF). SP group included TTF between 16.63 46.57 min, HP TTF>46.57 min. Isolated ventricular dissociated hearts rats, intracellular global ([Ca2+]i) transients measured. [Ca2+]i transient peak increased in...
BACKGROUND AND PURPOSE Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning diabetes is associated with abnormal vasoconstriction Ca 2+ handling by smooth muscle cells (SMC). Phosphatidylinositol 3‐kinases (PI3K) are key mediators insulin action have been shown to modulate function voltage‐dependent L‐type channels (Ca V 1.2). In present work, we investigated involvement PI3K signalling regulating current through 1.2 ( I Ca,L ) vascular...
Paraquat is a toxic herbicide that may induce acute lung injury, circulatory failure and death. The present work aimed at investigating whether there systemic inflammation vascular dysfunction after paraquat exposure these parameters were related. There was neutrophilia accumulation of neutrophils in bronchoalveolar lavage animals given paraquat. This associated with an increase serum levels TNF-α. In rats paraquat, the relaxant response aortic rings to acetylcholine not modified but...
The perivascular adipose tissue (PVAT) is located around the adventitia, composed primarily by adipocytes, stromal cells, leukocytes, fibroblasts and capillaries. It well described that PVAT an important modulator of vascular tone being considered a biologically active tissue, releasing both vasoconstrictor vasodilators factors. literature shows anti-contractile effect induced may be due to activation renin-angiotensin system (RAS). Investigate whether participates in exerted on tone. For...
Capsaicin, a bioactive compound found in peppers, is recognized for its anti-inflammatory, antioxidant, and anti-lipidemic properties. This study aimed to evaluate the effects of capsaicin on atherosclerosis progression.