A5051434718- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Child Nutrition and Water Access
- Nutritional Studies and Diet
- Food Security and Health in Diverse Populations
- Folate and B Vitamins Research
- Receptor Mechanisms and Signaling
- Asthma and respiratory diseases
- Glioma Diagnosis and Treatment
- Biochemical effects in animals
- Allergic Rhinitis and Sensitization
- Cancer, Hypoxia, and Metabolism
- Obesity, Physical Activity, Diet
- Meat and Animal Product Quality
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Nutrition, Health, and Society Studies
- Iron Metabolism and Disorders
- Vitamin C and Antioxidants Research
- Mast cells and histamine
- Body Composition Measurement Techniques
- Birth, Development, and Health
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
Epigen Biosciences (United States)
2016-2023
University of Florida
2022
Neurocrine Biosciences (United States)
2009-2011
Drug Discovery Laboratory (Norway)
2010
PRA Health Sciences
2009
Deltagen (United States)
2008
Delta Air Lines (United States)
2004
Maxygen (United States)
2004
University of Toronto
1965-1996
University of Colorado Boulder
1992
Neuroinflammation is a major component in the transition to and perpetuation of neuropathic pain states. Spinal neuroinflammation involves activation TLR4, localized enlarged, cholesterol-enriched lipid rafts, designated here as inflammarafts. Conditional deletion cholesterol transporters ABCA1 ABCG1 microglia, leading inflammaraft formation, induced tactile allodynia naive mice. The apoA-I binding protein (AIBP) facilitated depletion from inflammarafts reversed model chemotherapy-induced...
Analogues of the known H(1)-antihistamine R-dimethindene were profiled as potential agents for treatment insomnia. Several highly selective compounds efficacious in rodent sleep models. On basis overall profile, indene 1d and benzothiophene 2a had pharmacokinetic properties suitable evaluation night time dosing. Compound did not show an vivo cardiovascular effect from weak hERG channel inhibition.
Phosphorothioate oligodeoxynucleotides exert a sequence-independent cytoprotective effect against human immunodeficiency virus type 1 (HIV-1). We now report that phosphorodithioate-containing oligodeoxycytidines are very potent inhibitors of HIV-1 reverse transcriptase in vitro, as they exhibit an increasing inhibitory with length and number phosphorodithioate internucleotide linkages. This can be at least 30-fold greater oligodeoxycytidine than for the corresponding phosphorothioate analog...
To evaluate the pharmacokinetics (PK) of five H(1) receptor antagonists in human volunteers after a single oral and intravenous (i.v.) microdose (0.1 mg).Five antagonists, namely NBI-1, NBI-2, NBI-3, NBI-4 diphenhydramine, were administered to as 0.1-mg i.v. dose. Blood samples collected up 48 h, parent compound plasma extract was quantified by high-performance liquid chromatography accelerator mass spectroscopy.The median clearance (CL), apparent volume distribution (V(d)) terminal...
The lowering of blood glutamic–oxaloacetic (GOT) and glutamic–pyruvic (GPT) transaminase activities was found to be specific for vitamin B 6 deprivation among several vitamins tested in the presence a simultaneous restriction eight vitamins, cortisone administration, or variation dietary protein level. It that changes activity did not always parallel those seen liver activity. In determination nutritional status, GPT appeared more sensitive than GOT would seem as an indicator xanthurenic...
In the adult male rat, an acute dosage of anterior pituitary growth hormone caused significant depressions in rate urea formation by liver slices, arginase activity, and alanine-glutamic transaminase activity but did not alter aspartic-glutamic activity. None these effects were observed young rats, such animals, a elevation was noted.
DL-Penicillamine administered in the diet at 0.25% level produced a marked lowering of food intake and body weight. Using blood transaminase activities as criteria, definite antagonism to vitamin B 6 was demonstrated. The response animals drug did not differ between sexes. Transaminase activity changes were apparent within 13 days treatment. They result reduced intake. Administration 800 μg pyridoxine hydrochloride per 10 g receiving penicillamine approximated maximal prevention effects upon...
Journal Article GLUCAGON ADMINISTRATION IN PREGNANT RATS Get access Endocrinology, Volume 63, Issue 2, 1 August 1958, Pages 252–254, https://doi.org/10.1210/endo-63-2-252 Published: 01 1958 history Received: 10 February
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It has been demonstrated, using doses of cortisone 5 to 20 mg. per day, that pregnant rats exhibit a marked resistance the biochemical effects administration. This was evident with respect changes in alanine-glutamic transaminase activity, blood amino nitrogen and sugar levels balance data. There no apparent increase liver weightproduced by hormone. Removal fetus alone did not affect this whereas removal both placenta abolished it. concluded is essential for maintenance effectsof seen rat....
To assess the usefulness of erythrocyte transaminases, glutamic–oxaloacetic and glutamic–pyruvic, in evaluation vitamin B 6 nutritional status, response these enzymes to repletion following 1, 4, 10 weeks depletion was compared with that plasma liver transaminases rat. The responses reflected state nutrition most accurately and, unlike were not affected by other factors. Repletion produced a rapid enzymes; however, restoration control levels appeared depend on red cell turnover, particularly...