A5057780818- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Blood disorders and treatments
- Receptor Mechanisms and Signaling
- Neutropenia and Cancer Infections
- melanin and skin pigmentation
- Immunodeficiency and Autoimmune Disorders
- Chemical Synthesis and Analysis
- Hypothalamic control of reproductive hormones
- Supramolecular Chemistry and Complexes
- Estrogen and related hormone effects
- Organic Chemistry Cycloaddition Reactions
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Gastroesophageal reflux and treatments
- Fungal Infections and Studies
- Organoselenium and organotellurium chemistry
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Eosinophilic Esophagitis
- Platelet Disorders and Treatments
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
Epigen Biosciences (United States)
2016-2024
Urology San Antonio
2023
Meyer Children's Hospital
2011-2020
Boston Children's Hospital
2015
Meyer (China)
2014
University of Parma
2012
Neurocrine Biosciences (United States)
2002-2011
University of Florence
1991-2010
University of Bari Aldo Moro
2006
University of Padua
2006
PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), evaluate their clinical management. PATIENTS AND METHODS: TPMT metabolism assessed all referred between 1994 1999 for evaluation of excessive toxicity while receiving MP AZA. activity was measured by radiochemical analysis, determined mutation-specific polymerase chain reaction restriction fragment length polymorphism...
Diabetic kidney disease (DKD) can lead to end-stage (ESKD) and mortality; however, few mechanistic biomarkers are available for high-risk patients, especially those without macroalbuminuria. Urine from participants with diabetes the Chronic Renal Insufficiency Cohort (CRIC) study, Singapore Study of Macro-angiopathy Micro-vascular Reactivity in Type 2 Diabetes (SMART2D), American Indian determined whether urine adenine/creatinine ratio (UAdCR) could be a biomarker ESKD. ESKD mortality were...
The synthesis and spectroscopic characterization of self-assembled cylindrical capsule 1 a⋅1 a nanometer dimensions is described. Encapsulation studies large organic guest molecules were performed by using 1H NMR sprectroscopy in [D12]mesitylene solution. In addition to the computational (MacroModel 5.5, Amber* force field) analysis capsule's shape geometry, an experimental approach towards estimation internal cavity This involves series homologous molecular "rulers" (e.g. aromatic amides 5...
The total synthesis of (−)-macrolactin A, a 24-membered macrolide, has been achieved using newly developed 1,3-diol synthon for the introduction two key stereogenic centers. was derived from sequential use Noyori asymmetric reduction followed by chiral sulfoxide methodology. Tellurium-derived cuprate organometallics offered an efficient and highly stereoselective means installation C8 Z/E-diene, while C15 E/E-segment Julia−Lythgoe olefination. Yamaguchi lactonization used to secure...
Data on epidemiology and survival after fungal infections in patients with cancer are primarily based studies adults, whereas few data available children.A prospective, multicenter, 2-year surveillance of children receiving antineoplastic treatment was performed 15 Italian centers. For each case, defined by means EORTC-IFIG/NIAID-MSG, information collected age, phase treatment, presence neutropenia or lymphocytopenia, administration antifungal drugs survival.Ninety-six episodes (42 proven...
The discovery of novel uracil phenylethylamines bearing a butyric acid as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonists is described. A major focus this optimization was to improve the CYP3A4 inhibition liability these uracils while maintaining their GnRH-R potency. R-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric sodium salt, 10b (elagolix), identified and...
Z-Vinylic tellurides, obtained with 100% stereoselectivity by the hydrotelluration of acetylenes, are easily transformed into Z-vinylic higher order cyanocuprates reaction preformed Me2Cu(CN)Li2, n-Bu2Cu(CN)Li2, or n-Bu(2-Th)Cu(CN)Li2, total retention double-bond configuration. The resulting vinylic react unhindered enones to give corresponding 1,4-addition products in good yields. Reaction monosubstituted epoxides at 0 °C gives homoallylic alcohols from attack less-substituted carbon atom,...
We evaluated the prevalence of gastroesophageal reflux in 36 children, 22 (61.2%) male and 14 (38.8%) female (median age, 75.5 months; range, 18-178), with noncontrolled asthma by means prolonged (22-24 h) esophageal pH monitoring. None children had gastrointestinal symptoms suggesting reflux. Atopy was seen 21 (58.3%) patients. Pathological present 27 (75%) children. All patients were given cisapride (0.2 mg/kg q.i.d.) for 3 months. A clinical pharmacological score determined, a second...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDeeper CavitandsFabio C. Tucci, Dmitry M. Rudkevich, and Julius RebekView Author Information The Skaggs Institute for Chemical Biology Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037 Cite this: J. Org. Chem. 1999, 64, 12, 4555–4559Publication Date (Web):May 1999Publication History Received3 February 1999Published online12 May inissue 1 June...
Fungal infections are diagnosed increasingly often in patients affected by hematological diseases and their mortality has remained high. The recent development of new antifungal drugs gives the clinician possibility to assess combination with in-vitro or animal-model synergistic effect. We analyzed retrospectively safety efficacy caspofungin-based therapy 40 children adolescents, most them were being treated for a malignant disease, who developed invasive aspergillosis (IA) between November...
Analogues of the known H(1)-antihistamine R-dimethindene were profiled as potential agents for treatment insomnia. Several highly selective compounds efficacious in rodent sleep models. On basis overall profile, indene 1d and benzothiophene 2a had pharmacokinetic properties suitable evaluation night time dosing. Compound did not show an vivo cardiovascular effect from weak hERG channel inhibition.
Abstract Background The eradication of Helicobacter pylori has been associated with remission immune thrombocytopenia (ITP) in approximately half eradicated patients. Data on children are limited to small case series. Procedure Children from 16 centers Italy, who were less than 18 years age and diagnosed chronic ITP (cITP), screened for H. infection. Positive patients underwent standard triple therapy amoxicillin, clarithromycin, omeprazole. response was defined as follows: complete...
The management of congenital and acquired neutropenias presents some differences according to the type disease. Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is not standardized scanty data are available on best schedule apply. frequency longitudinal controls in patients affected usually discussed literature. Neutropenia Committee Marrow Failure Syndrome Group (MFSG) Associazione Italiana di Emato-Oncologia Pediatrica (AIEOP) elaborated this document...
Fanconi anemia is an inherited disease characterized by congenital malformations, pancytopenia, cancer predisposition, and sensitivity to cross-linking agents. The molecular diagnosis of relatively complex for several aspects including genetic heterogeneity with mutations in at least 16 different genes. In this paper, we report the identified 100 unrelated probands enrolled into National Network Italian Association Pediatric Hematoly Oncology. approximately half these cases, mutational...
Long-term granulocyte-colony stimulating factor treatment has been shown to be safe and effective in severe chronic neutropenia patients. However, data on its use during pregnancy are limited. To address this issue, we analyzed all pregnancies reported the European branch of Severe Chronic Neutropenia International Registry since 1994. A total 38 21 women with (16 10 congenital, 6 cyclic, 12 5 idiopathic neutropenia) were reported. Granulocyte-colony was administered throughout 16 for at...
Intermolecular alkylation of the aziridinyl oxazole 20 using PhSO2CH2CH2OTf is possible despite presence potentially nucleophilic aziridine nitrogen. The resulting oxazolium salt 22 reacts with BnNMe3(+)CN(−) to produce azomethine ylide 24b via electrocyclic ring opening an oxazoline 23b. Internal cycloaddition affords 26 in 66% yield. After saponification and base-induced cleavage N-phenylsulfonylethyl group, conventional cyclization provides access 33. Deprotection DDQ oxidation completes...
New types of resorcinarene-based nanoscale container molecules 2 and 3 are described. They feature reversibly folding unimolecular cavities dimensions ∼800 Å3 internal volume; they among the largest synthetic hosts prepared to date. Two seams intramolecular hydrogen bonds, provided by 12 secondary amides, control guest uptake release. The bonds resist unfolding host increase energetic barrier exchange. Exchange is slow on NMR time scale (room temperature), kinetically stable complexes...