A5011938116- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Intestinal Malrotation and Obstruction Disorders
- COVID-19 Clinical Research Studies
- Digestive system and related health
- Pregnancy and Medication Impact
- COVID-19 and healthcare impacts
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Child Nutrition and Feeding Issues
- Pharmaceutical studies and practices
- Gastrointestinal motility and disorders
- Liver Diseases and Immunity
- SARS-CoV-2 and COVID-19 Research
- Microbial Metabolites in Food Biotechnology
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Gastroesophageal reflux and treatments
- Autoimmune and Inflammatory Disorders
- Autoimmune and Inflammatory Disorders Research
Ospedale Maggiore Carlo Alberto Pizzardi
2004-2025
Ospedale Maggiore
2013-2024
Azienda USL di Bologna
2015-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2008-2022
Tel Aviv University
2017-2022
Sheba Medical Center
2017
University of Bologna
2007
Bambino Gesù Children's Hospital
2001
Policlinico S.Orsola-Malpighi
1999
Istituto Giannina Gaslini
1995
MYH9-related disease (MYH9-RD) is a rare autosomal-dominant disorder caused by mutations in MYH9, the gene for heavy chain of nonmuscle myosin IIA (NMMHC-IIA). All patients present from birth with macrothrombocytopenia, but infancy or adult life, some them develop sensorineural deafness, presenile cataracts, and/or progressive nephritis leading to end-stage renal failure. No consistent correlations have been identified between 27 different MYH9 so far and variable clinical evolution disease....
Early-onset (EO) pediatric inflammatory bowel diseases (IBD) seem to be more extensive than those with a later onset. To test this hypothesis, we examined the phenotype and disease course of patients IBD diagnosis at 0 5 years, compared ranges 6 11 12 18 years.Anatomic locations behaviors were assessed according Paris classification in 506 consecutive patients: 224 Crohn's disease, 245 ulcerative colitis, 37 IBD-unclassified.Eleven percent range 39% 50% years. Ulcerative colitis was most...
PURPOSE: To report on the treatment of patients with newly diagnosed neuroblastoma presenting spinal cord compression (SCC). PATIENTS AND METHODS: Of 1,462 children registered between 1979 and 1998, 76 (5.2%) presented signs/symptoms SCC, including motor deficit in 75 (mild 43, moderate 22, severe [ie, paraplegia] 10), pain 47, sphincteric 30, sensory loss 11. Treatment SCC consisted radiotherapy 11 patients, laminectomy 32, chemotherapy 33. Laminectomy was more frequently performed cases...
Abstract Background In a 6-year, multicenter, prospective nested case–control study, we aimed to evaluate risk factors for incident cancer in inflammatory bowel disease (IBD), when considering clinical characteristics of IBD and immunomodulator use. The secondary end point was provide characterization types. Methods All cases occurring patients from December 2011–2017 were prospectively recorded 16 Italian Group the Study Inflammatory Bowel Disease units. Each with new diagnosis matched 2...
PURPOSE To optimize treatment for children with localized resectable neuroblastoma in 21 Italian institutions using a common protocol based on previous experience. PATIENTS AND METHODS Between January 1985 and December 1992, 152 aged 0 to 15 years nondisseminated were entered onto this study following complete resection of tumor without rupture (TR) (stage 1), or minimal residue, and/or infiltration regional lymph nodes (LN+), TR 2). Of 144 assessable children, 69 classified as having stage...
Anti-tumor necrosis factor antibodies have led to a revolution in the treatment of inflammatory bowel diseases (IBD); however, sizable proportion patients does not respond therapy. There is increasing evidence suggesting that failure may be classified as mechanistic (pharmacodynamic), pharmacokinetic, or immune-mediated. Data regarding contribution these factors children with IBD treated infliximab (IFX) are still incomplete. The aim was assess causes prospective cohort pediatric IFX.This...
Objectives: Escalation of the ustekinumab (UST) maintenance dosage was effective in adults with Crohn disease (CD), but no data are available for children. We evaluated effectiveness and safety dose escalation UST pediatric CD. Methods: This a retrospective multicenter study from 25 centers affiliated IBD Interest Porto groups ESPGHAN. included children CD who initiated at standard dosing underwent either to intervals shorter than 8 weeks or re-induction due active disease. Demographic,...
Background and Aims:Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer IBD. The role immunomodulators vs clinical characteristics IBD as factors for was also investigated.
Very few data regarding the use of infliximab in children with very early-onset inflammatory bowel disease (VEO-IBD) have been reported.We aimed to assess efficacy and safety VEO-IBD compared older children.Children treated were identified within Italian IBD registry. The primary outcome was rate clinical remission at weeks 14 54. Secondary outcomes included proportion partial response, treatment duration, incidence adverse events.Forty-two 130 IBD. Despite significantly higher withdrawals...
Wrong dietary habits, such as the Western-style diet, are considered important risk factors for development of Inflammatory Bowel Diseases (IBDs). Nevertheless, role patterns in clinical management IBD patients has not been fully investigated yet. Fifty-four diagnosed with active Crohn's disease (CD) were enrolled and subjected to nutritional intake analysis through a weekly food diary. Nutritional analyzed, nutrient was compared those 30 healthy subjects (HS). Blood levels cholesterol,...
Abstract Background Acute severe colitis (ASC) is a potentially life-threatening event. Optimal timing for second-line treatment in children mainly based on the clinical score Pediatric Ulcerative Colitis Activity Index (PUCAI) score. The aim of our study was to evaluate potential role bowel ultrasound scan (BUS) predicting short-term outcomes pediatric ASC. Methods This prospective longitudinal study, conducted across ten European centers between March 2020 and 2024. Biologic-naïve with...
Abstract Objectives We determined the prevalence of anemia and its characteristics in children with newly diagnosed inflammatory bowel disease (IBD) investigated trend during follow‐up. Methods An observational, multicenter cohort study IBD at diagnosis enrolled Italian Society Pediatric Gastroenterology, Hepatology, Nutrition registry. Data were collected 1 year. Results Five hundred eighty‐nine (295 Crohn's [CD] [50%] 294 ulcerative colitis [UC]/IBD unclassified [IBDU] [50%]) 1634 patients...
Abstract Background The natural history of Crohn’s disease (CD) can result in complications requiring surgery. Pediatric data are scarce about major abdominal IBD Registry from the Italian Society Gastroenterology, Hepatology, and Nutrition has been active since 2008 collects pediatric centers Italy. aim present report was to explore prevalence surgery among children affected by CD an era when antitumor necrosis factor (anti-TNF-α) agents were already used so that we might appraise incidence...
Abstract Background Pan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn’s disease (CD), especially in children. No study has evaluated ability PCE to characterize CD phenotypes and outcomes children adults. Methods In a prospective multicenter observational study, we recruited patients with >6 years from 4 centers Italy. Patients underwent clinical, biomarker assessment PCE. Lesions were graded using system. For each segment, most common lesion...
This study described disease characteristics and long-term outcomes in patients diagnosed with very early onset inflammatory bowel (VEOIBD) (diagnosed before 6 years of age) infantile-IBD (before 2 years).
The syndrome of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) is a rare disorder caused by mutations in the FOXP3 gene. Diarrhea, diabetes and dermatitis are hallmark disease, with typical onset within first months life. We describe case twelve-year old male affected very late-onset IPEX intractable which markedly improved after starting Sirolimus as second-line treatment. This suggests that should always be considered differential diagnosis watery diarrhea, despite...