A5077442804- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microscopic Colitis
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Diverticular Disease and Complications
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Digestive system and related health
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Spondyloarthritis Studies and Treatments
- Appendicitis Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Congenital gastrointestinal and neural anomalies
- Anorectal Disease Treatments and Outcomes
- Cannabis and Cannabinoid Research
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
- Congenital Anomalies and Fetal Surgery
Azienda USL di Bologna
2021-2025
University of Bologna
2020-2025
Policlinico S.Orsola-Malpighi
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2024
Crohn's disease (CD) is a chronic disorder of the digestive tract characterized by an uncontrolled immune-mediated inflammatory response in genetically predisposed individuals exposed to environmental risk factors. Although diet has been identified as one major factors, role nutrients clinical management CD patients not yet fully investigated. In this prospective observational study, fifty-four diagnosed with active and undergoing anti-TNF-α biological therapy were enrolled subjected...
Background COVID-19, whose causative pathogen is the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic in March 2020. The gastrointestinal tract one of targets this virus, and mounting evidence suggests that symptoms may contribute to disease severity. gut–lung axis involved immune response SARS-CoV-2; therefore, we investigated whether COVID-19 patients’ bacterial fungal gut microbiome composition linked clinical outcome. Methods In May 2020, collected...
Abstract Background Pan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn’s disease (CD), especially in children. No study has evaluated ability PCE to characterize CD phenotypes and outcomes children adults. Methods In a prospective multicenter observational study, we recruited patients with >6 years from 4 centers Italy. Patients underwent clinical, biomarker assessment PCE. Lesions were graded using system. For each segment, most common lesion...
The Montreal classification has been widely used in Crohn's disease since 2005 to categorize patients by the age of onset (A), location (L), behavior (B), and upper gastrointestinal tract perianal involvement. With evolving management paradigms disease, we aimed assess performance gastroenterologists applying classification. An online survey was conducted among participants at an international educational conference on inflammatory bowel diseases. Participants classified 20 theoretical cases...
Abstract Background Cytomegalovirus (CMV) colitis is a serious concern worsening the prognosis of patients with ulcerative (UC) as an independent risk factor for hospitalization and surgery. European guidelines indicate that immunohistochemistry [IHC], tissue polymerase chain reaction [PCR], or possibly both, are essential confirming active CMV in IBD should be considered standard tests. The aim our study to evaluate diagnostic performance different tests used diagnosis infection comparison...
Abstract Background Although ustekinumab has been evaluated for Crohn’s disease, long-term effectiveness and the benefits of dose intensification maintaining clinical endoscopic remission remain underexplored. Dose strategies may be critical optimizing outcomes in patients not responding to standard regimens. This study addresses these gaps by analyzing treatment impact a real-world setting. Methods retrospective, observational was conducted at tertiary referral center, investigating with...
Abstract Background Infliximab (IFX) is the first anti-TNF biologic drug approved for treating moderate to severe ulcerative colitis (UC). While IFX effective in inducing mucosal healing and enhancing quality of life, concerns persist about long-term safety cost-effectiveness extended immunosuppression. Current guidelines lack clarity on when discontinue treatment after achieving stable deep remission. Moreover, existing literature limited studies characterised by small sample sizes...
Abstract Background Intestinal ultrasound (IUS) is widely accepted as a reliable tool to monitor Crohn’s Disease (CD). The most important parameters for the assessment of bowel inflammation are wall thickness (BWT), parietal vascular signals evaluated by colour Doppler (CDS), loss stratification and increase in mesenteric inflammatory fat (i-fat). Some IUS scores have been proposed, but none formally international organizations lack external validation. aims our study were evaluate accuracy...
Abstract Spondyloarthritis (SpA), rheumatoid arthritis (RA), and inflammatory bowel diseases (IBD) are chronic autoimmune that associated with alterations in the composition of intestinal microbiota ( i.e ., dysbiosis). For SpA RA, a gut-joint-enthesis axis is hypothesized recent data suggests dysbiosis may contribute directly to initiating perpetuating joint spine inflammation. Biologic drugs targeting tumor necrosis factor (TNF) effective treating these have been shown partially restore...
Abstract Background Crohn’s disease (CD) can be classified according to endoscopic and cross-sectional imaging characteristics. Information regarding extent phenotype may provided by advanced techniques. In this study, we compare the ability of capsule endoscopy (CE) techniques (CST) (MRE/Computer Tomography Enteroscopy [CTE]) in detecting small bowel (SB) lesions. Methods We retrospectively analyzed 102 patients with a diagnosis CD who underwent both CE CST. Only at least 12-month follow-up...
Abstract Ectopic liver (EL) is a rare congenital anomaly characterized by the presence of mass composed hepatic tissue localized in different anatomical location with no connection to native liver. Usually an incidental finding, EL can rarely cause symptoms such as abdominal pain due torsion, intraperitoneal bleeding, compression, obstruction, or neoplastic transformation, both benign and malignant. often suspected after instrumental investigations ultrasound, CT MRI, however definitive...
Gastroesophageal reflux disease (GERD) is a digestive disorder that can lead to chronic mucosal damage, causing esophagitis, Barrett's esophagus and esophageal cancer. GERD currently affects about 13% of the world's population represent major public health concern due increasing prevalence incidence. The aim this study was explore complementary strategies for management based natural compound palmitoylethanolamide (PEA), alone or associated with plant extracts demonstrated anti-GERD activity (
Abstract Background Intestinal Ultrasound (IUS) is a non-invasive, widely available technique that can rapidly evaluate bowel wall thickness and provide direct visualization of vascularisation motility. Studies have shown high concordance between ultrasound MR enterography endoscopy for disease location activity, fewer technical difficulties associated with IUS. While more known about the role IUS in evaluating response to pharmacologic treatment CD patients, data regarding monitoring...
Crohn's disease (CD) and ulcerative colitis are chronic idiopathic inflammatory bowel diseases, characterized by gastrointestinal symptoms such as abdominal pain, fecal urgency, diarrhea1,2; extra intestinal manifestations that may involve almost any organ including the kidney. The most common renal nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis, amyloidosis. In addition, kidney damage in patients with CD result from dehydration, long-term malnutrition, anemia,...
Abstract Background Cytomegalovirus (CMV) colitis is a serious concern worsening the prognosis of patients with ulcerative (UC), involving mainly those who are not responding to immunosuppressive therapy. CMV an independent predictor hospitalisation and surgery. Diagnosis can be obtained either via immunohistochemistry (ICH) or tissue polymerase chain reaction (PCR), possibly both. We aimed assess prognostic impact in UC clinical utility testing for plasma-DNA reactivation. Methods conducted...
Nowadays, there is a clear need for new viable therapeutic options to face complex perianal Crohn's disease (PCD). Results of our previous pilot study demonstrated the efficacy and safety local injection autologous microfragmented adipose tissue (MFat) in this setting. This aims evaluate long-term follow-up results same cohort patients.
Abstract Background Both vedolizumab (VDZ) and ustekinumab (UST) are indicated in the treatment of Crohn’s disease (CD) when anti-TNF fails. While there some studies regarding efficacy these two drugs this setting, data lacking effectiveness UST VDZ-refractory disease. We aim to address particularly challenging clinical picture a real-world single-centre study. Methods CD patients from single tertiary IBD referral centre receiving with after failure VDZ minimum follow-up period 6 months were...
Abstract Background COVID-19 vaccines have demonstrated excellent efficacy and safety profiles among the general population. However, studies shown that vaccine hesitancy remains a significant problem especially in patients with chronic diseases, part because of lack data regarding these special populations. With this mind, we investigated rates vaccine-related side effects disease flares inflammatory bowel (IBD). Methods We conducted an online survey Crohn’s (CD) ulcerative colitis (UC) who...
Abstract Background Ustekinumab (UST) and vedolizumab (VDZ) are approved biologic therapies for moderate-to-severe Crohn’s disease (CD). Data regarding their comparative efficacy in patients previously treated with anti-TNF agents available. However, data is lacking long-term effectiveness after failure of a second or third-line treatment. Our aim to evaluate ustekinumab swapping from therapy primary secondary failure. Methods We conducted single-centre, retrospective study CD UST as third...