A5065638342- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Fatty Acid Research and Health
- Eosinophilic Esophagitis
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Clinical Nutrition and Gastroenterology
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Gastrointestinal motility and disorders
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Diverticular Disease and Complications
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Inflammatory mediators and NSAID effects
- Diagnosis and treatment of tuberculosis
- Lymphoma Diagnosis and Treatment
- Vasculitis and related conditions
- Pomegranate: compositions and health benefits
- Mycobacterium research and diagnosis
Policlinico S.Orsola-Malpighi
2013-2025
University of Bologna
2013-2022
Azienda USL di Bologna
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
University of Alberta
2013
Northwick Park Institute for Medical Research
2013
Centre for Inflammation Research
2013
Queen's Medical Centre
2013
University of Edinburgh
2013
Barts Health NHS Trust
2013
Patients with Crohn's disease may have periods of remission, interrupted by relapses. Because fish oil has antiinflammatory actions, it could reduce the frequency relapses, but is often poorly tolerated because its unpleasant taste and gastrointestinal side effects.
The effect of fish oil on the course ulcerative colitis was investigated in a randomised blinded controlled study. Eighty seven patients received supplements 20 ml HiEPA as triglyceride (4.5 g eicosapentaenoic acid) or olive placebo daily for one year. oils were given addition to standard drug therapy and trial entry stratified disease activity. Fish significantly increased acid content rectal mucosa 3.2% total fatty acids at six months, compared with 0.63% oil. This associated synthesis...
<h3>Objective</h3> The omega-3 polyunsaturated fatty acid eicosapentaenoic (EPA) has anticolorectal cancer activity in vitro and preclinical models. present study tested whether a novel, enteric-coated formulation of EPA, as the free (EPA-FFA), chemopreventative efficacy patients with familial adenomatous polyposis (FAP), randomised, double-blind, placebo-controlled trial. <h3>Methods</h3> Patients undergoing endoscopic surveillance their retained rectum postcolectomy were randomised to...
Oral administration of the omega-3 fatty acid eicosapentaenoic (EPA), as free (FFA), leads to EPA incorporation into, and reduced growth of, experimental colorectal cancer liver metastases (CRCLM).We performed a Phase II double-blind, randomised, placebo-controlled trial EPA-FFA 2 g daily in patients undergoing resection surgery for CRCLM. The took (n=43) or placebo (n=45) prior surgery. primary end-point was CRCLM Ki67 proliferation index (PI). Secondary end-points included safety...
Inflammatory bowel diseases are associated with increased risk of developing colitis-associated colorectal cancer (CAC). Epidemiological data show that the consumption ω-3 polyunsaturated fatty acids (ω-3 PUFAs) decreases sporadic (CRC). Importantly, recent have shown eicosapentaenoic acid-free acid (EPA-FFA) reduces polyp formation and growth in models familial adenomatous polyposis. However, effects dietary EPA-FFA unknown CAC. We tested effectiveness substituting EPA-FFA, for other fats,...
5-Aminosalicylic acid (5-ASA), the active moiety of sulphasalazine (SASP), was given as a rectal enema to patients with mild moderate distal ulcerative colitis determine minimum effective dosage. A double blind study carried out using enemas containing 1, 2, or 4 g 5-ASA placebo for one month treatment period. One hundred and thirteen attending our outpatient clinic volunteered participate. Clinical, sigmoidoscopic, histological assessments were at beginning after 15 30 days treatment. All...
The ω-3 polyunsaturated fatty acid eicosapentaenoic (EPA), in the free (FFA) form, has been demonstrated to reduce adenoma number and size patients with familial adenomatous polyposis. However, mechanistic basis of antineoplastic activity EPA colorectum remains unclear. We tested hypothesis that EPAFFA negatively modulates synthesis signaling by prostaglandin (PG) E2 human colorectal cancer (CRC) cells. EPA-FFA induced apoptosis cyclooxygenase (COX)-2-positive HCA-7 CRC cells vitro. cell...
Abstract Purpose: Although cyclooxygenase (COX)-2 inhibitors could represent the most effective chemopreventive tool against colorectal cancer (CRC), their use in clinical practice is hampered by cardiovascular side effects. Consumption of ω-3-polyunsaturated fatty acids (ω-3-PUFAs) associated with a reduced risk CRC. Therefore, this study, we assessed efficacy novel 99% pure preparation ω-3-PUFA eicosapentaenoic acid as free (EPA-FFA) on polyps ApcMin/+ mice. Experimental design: and...
Abstract Patients with long-standing ulcerative colitis (UC) have an increased colorectal cancer (CRC) risk. In this pilot study we evaluated the effect of Eicosapentaenoic acid as free fatty (EPA-FFA) supplementation on mucosal disease activity, colonic differentiation markers and microbiota composition in UC patients. Twenty patients stable clinical remission fecal calprotectin (FC) > 150 µg/g were enrolled (T0) supplemented EPA-FFA 2 g/daily for 90 days (T3). Endoscopic histologic...
Abstract Aberrant NOTCH1 signalling is critically involved in multiple models of colorectal cancer (CRC) and a prominent role activity during inflammation has emerged. Epithelial to Mesenchymal Transition (EMT), crucial event promoting malignant transformation, regulated by Metalloproteinase-9 (MMP9) plays an important this process. Eicosapentaenoic Acid (EPA), omega-3 polyunsaturated fatty acid, was shown prevent colonic tumors different settings. We recently found that extra-pure...
Thirty-nine patients with documented active distal proctitis (<20 cm) received either 5-aminosalicylic acid (5-ASA) enemas (2 g in 100 ml) or suppositories 1 b.i.d., a controlled study. Twenty enemas, while 19 suppositories, for 30 days. No difference could be observed terms of efficacy; however, it was the patients' opinion that treatment easier than (p < 0.01).
BACKGROUND AND PURPOSE The omega‐3 polyunsaturated fatty acid (PUFA) eicosapentaenoic (EPA) has antineoplastic activity at early stages of colorectal carcinogenesis, relevant to chemoprevention cancer (CRC). We tested the hypothesis that EPA also anti‐CRC later treatment metastatic CRC, via modulation E‐type PG synthesis. EXPERIMENTAL APPROACH A BALB/c mouse model, in which intrasplenic injection syngeneic MC‐26 CRC cells leads development liver metastases, was used. Dietary administered...
Objectives: Unhealthy dietary patterns have been associated with colorectal cancer (CRC) onset while Mediterranean Diet (MD) has proposed for CRC prevention. This study evaluated the effect of a Mix (MD-MIX) on colonic tumors development in A/J mice fed low-fat (LFD) or high-fat western diet (HFWD), and injected procarcinogen azoxymethane (AOM). Materials Methods: Forty male were randomly assigned into four feeding arms (10 mice/arm; LFD, LFD-MD-MIX, HFWD, HFWD-MD-MIX) to be treated AOM. Ten...
Background . Inflammatory bowel diseases (IBD) are associated with stress, poor quality of life, and attachment insecurity. Mentalization is the human ability to perceive reason about feelings psychological dispositions one’s self others. The chronic disorders believed affect patients’ mentalizing abilities determine a shift towards insecurity in patients affected. In this study, dimensions mentalization were assessed IBD healthy controls. Further knowledge interplay among IBD,...