Yongsheng Chen

ORCID: 0000-0003-0597-814X
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About
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Research Areas
  • Phytochemicals and Antioxidant Activities
  • Tea Polyphenols and Effects
  • Natural Antidiabetic Agents Studies
  • Phytochemistry and Biological Activities
  • Natural product bioactivities and synthesis
  • RNA Interference and Gene Delivery
  • Genetic Mapping and Diversity in Plants and Animals
  • Hypothalamic control of reproductive hormones
  • Adenosine and Purinergic Signaling
  • Global Cancer Incidence and Screening
  • Advanced biosensing and bioanalysis techniques
  • Perovskite Materials and Applications
  • Receptor Mechanisms and Signaling
  • ATP Synthase and ATPases Research
  • Enzyme Catalysis and Immobilization
  • Pancreatic and Hepatic Oncology Research
  • Estrogen and related hormone effects
  • Helicobacter pylori-related gastroenterology studies
  • Free Radicals and Antioxidants
  • Cancer-related molecular mechanisms research
  • Plant Gene Expression Analysis
  • Ferroptosis and cancer prognosis
  • Food composition and properties
  • Wheat and Barley Genetics and Pathology
  • Flavonoids in Medical Research

Jinan University
2016-2025

Nankai University
2024-2025

State Key Laboratory of Pollution Control and Resource Reuse
2024-2025

Nanjing University
2024-2025

Inner Mongolia Agricultural University
2025

Harbin Medical University
2014-2024

Third Affiliated Hospital of Harbin Medical University
2016-2024

Qidong Liver Cancer Prevention Research
2012-2023

WuXi AppTec (China)
2018-2023

State Ethnic Affairs Commission
2023

Starch has received much attention as a promising natural material both in biomedical fields and waste water treatment due to its unique biological adsorptive properties.

10.1039/c5ra10849g article EN RSC Advances 2015-01-01

Mango (Mangifera indica L.), also called “the king of fruits”, is one the most popular fruits in tropical regions. Pulp and peel samples mango cultivars were analyzed to estimate total phenolic, flavonoid anthocyanin contents. Phenolic acids, hydrophilic peroxyl radical scavenging capacity (hydro-PSC) oxygen (ORAC) vitro determined. Total phenolics contents found maximum Xiao Tainang Da cultivars, respectively, whereas exhibited significant antioxidant capacity. Noteworthy, concentrations...

10.3390/ijms160613507 article EN International Journal of Molecular Sciences 2015-06-12

The discovery of novel uracil phenylethylamines bearing a butyric acid as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonists is described. A major focus this optimization was to improve the CYP3A4 inhibition liability these uracils while maintaining their GnRH-R potency. R-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric sodium salt, 10b (elagolix), identified and...

10.1021/jm8006454 article EN Journal of Medicinal Chemistry 2008-11-12

We performed ultrasound-assisted extraction coupled with natural deep eutectic solvents (NADES) to achieve the green and efficient preparation of flavonoid extract from Ampelopsis grossedentata leaves. then evaluated its antioxidant antiproliferative activities. A NADES consisting choline chloride glucose at a molar ratio 4:1 20% water was determined be most suitable solvent. The optimal conditions were: liquid-to-solid 30 mL/g, an ultrasonication power 490 W, time 6.5 min. actual yield...

10.3390/foods11050668 article EN cc-by Foods 2022-02-24

Consumption of plant foods has been negatively associated with the risk developing chronic diseases, which is partly attributed to their rich and diverse phytochemicals. To promote rational effective application Adinandra tea (Adinandra Jack), a traditional Chinese (Shiyacha) widely consumed as health beverage, complete phytochemical profile antioxidant activity four varieties were analyzed. They in phenolics flavonoids, ranging from 71.29 140.54 mg gallic acid equivalent/g 19.13 88.72...

10.1021/jf503700v article EN Journal of Agricultural and Food Chemistry 2014-12-10

Increased consumption of vegetables or plant food has been associated with decreased risk developing major chronic diseases, such as cancers, diabetes, cardiovascular and age-related functional decline. Ramie leaves are rich in phenolics flavonoids, which have suggested for human health benefits. Phenolic contents, flavonoid phenolic compounds, anti-cancer properties six species ramie were analyzed by Folin-reagent method, sodium borohydride/chloranil-based assay (SBC), HPLC method...

10.1371/journal.pone.0108140 article EN cc-by PLoS ONE 2014-09-22

Phytochemical composition, in vitro antioxidant and antiproliferative activity against HepG2 cells were studied the kernels of apricot cultivars grown northern areas Pakistan. Relatively, kernel Habbi cultivar/AP-12 depicted significant potential to scavenge DPPH ABTS+ free radicals as well oxygen radical absorbance capacity along with highest contents total flavonoids, phenolics, chlorogenic syringic acids on dry weight basis. The average concentration quercetin ranged 0.072-1.343 mg/100 g,...

10.1016/j.sjbs.2019.06.013 article EN cc-by-nc-nd Saudi Journal of Biological Sciences 2019-06-19

Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of renal cancer (RC) cells needs a thorough inquiry. This study was assigned probe effect and mechanism HOTAIR on sunitinib RC.Clinical RC tissues para-carcinoma were obtained detect expressions miR-17-5p, Beclin1. Sunitinib-resistant (786-O-R ACHN-R) constructed using parental (786-O ACHN). The 786-O-R ACHN-R examined. Western blot qRT-PCR assayed obtain...

10.1186/s12935-020-01419-0 article EN cc-by Cancer Cell International 2020-07-24

Novel ovotransferrin fibril–xanthan gum hydrogels were assembled to deliver dihydromyricetin effectively.

10.1039/c9fo02564b article EN Food & Function 2020-01-01

Hydrogel-based material have been demonstrated promising potential for hemostasis. Herein, we prepared a composite hydrogel (CH-P 40%) by combining pectin and cellulose in ionic liquid. The superficial morphology of the CH-P 40% was explored SEM; internal chemical bonds, crystal form thermal stability were determined via FTIR, XRD thermogravimetric analysis, respectively. biocompatibilities evaluated MTT, flow cytometry, histological observation with H&E staining. Furthermore,...

10.3389/fbioe.2020.627351 article EN cc-by Frontiers in Bioengineering and Biotechnology 2021-02-02

Ruda-6 (RD-6), a typical traditional Mongolian medicine formulae consisting of 6 herbs, has been traditionally used in treating gastric disorders. Even though it shown to protect against ulcers (GU) animal models, the gut microbiome and serum metabololite-related mechanisms that prevent GU are not well understood.This study was conducted evaluate gastroprotective mechanism RD-6 associated with alteration metabolic profiles rats.RD-6 (0.27, 1.35 2.7 g/kg) or ranitidine (40 mg/kg) were orally...

10.1016/j.jep.2023.116545 article EN cc-by-nc-nd Journal of Ethnopharmacology 2023-05-17

Consumption of cereal foods has been related to health improvement, which is partly because their phytochemicals. To explore the functionality and effective application barley malt, a widely consumed nutritional food, entire phytochemical profiles bioactivities three common malt products obtained under different roasting temperatures were analyzed. Results showed that they are abundant in phenolics including flavonoids with high antioxidative activities, as displayed by cellular antioxidant...

10.1039/c9fo00168a article EN Food & Function 2019-01-01

ATP citrate lyase (ACLY) is a key enzyme of lipogenesis in cells. However, ACLY expression renal cell carcinoma (RCC) and its association with clinicopathological parameters remain unclear. The present study aimed to evaluate levels RCC adjacent normal tissues. This included 33 patients clear (ccRCC). protein was assayed using immunohistochemistry western blotting methods. mRNA determined by reverse transcription‑quantitative polymerase chain reaction. Serum concentrations were measured the...

10.3892/ol.2018.8211 article EN Oncology Letters 2018-03-08

The sunflower (Helianthus annuus L.), belonging to the Asteraceae family, is world's fourth most important oil crop. Sunflower cultivars are categorized into oilseed and confectionery types. Here, we present chromosome-level genome assemblies of two Chinese cultivars-oilseed confectionery-using PacBio HiFi Hi-C sequencing. cultivar, OXS, has a assembly spanning 3.03 Gb with 99.58% sequences anchored 17 chromosomes contig N50 length 154.78 Mb. first published cultivar genome, YDS, mirrors...

10.1038/s41597-024-04097-z article EN cc-by-nc-nd Scientific Data 2025-01-07

The potential applications of circularly polarized phosphorescent materials in chiroptical devices have attracted considerable interest. Nevertheless, the design efficient near-infrared/red pure organic remains a significant challenge, largely due to limitations imposed by energy-gap law and Wallach's rule. In this study, chiral metal-free perovskite strategy is employed overcome these restrictions. introduction cyclohexylenediammonium cations as A-site perovskites results generation an...

10.1002/anie.202501360 article EN Angewandte Chemie International Edition 2025-03-10

Abstract The potential applications of circularly polarized phosphorescent materials in chiroptical devices have attracted considerable interest. Nevertheless, the design efficient near‐infrared/red pure organic remains a significant challenge, largely due to limitations imposed by energy‐gap law and Wallach's rule. In this study, chiral metal‐free perovskite strategy is employed overcome these restrictions. introduction cyclohexylenediammonium cations as A‐site perovskites results...

10.1002/ange.202501360 article EN Angewandte Chemie 2025-03-09
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