A5014062236- Cardiovascular and exercise physiology
- Cardiac electrophysiology and arrhythmias
- Exercise and Physiological Responses
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Cardiac pacing and defibrillation studies
- Health and Lifestyle Studies
- Traditional Chinese Medicine Analysis
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Tryptophan and brain disorders
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Obesity, Physical Activity, Diet
- Hormonal Regulation and Hypertension
- Atrial Fibrillation Management and Outcomes
- CRISPR and Genetic Engineering
- Coronary Artery Anomalies
- Neurogenesis and neuroplasticity mechanisms
- Ginkgo biloba and Cashew Applications
- Heat shock proteins research
Cedars-Sinai Smidt Heart Institute
2022-2025
Cedars-Sinai Medical Center
2022-2025
Universidade Federal de Sergipe
2015-2024
Norwegian University of Science and Technology
2019-2024
Exercise training promotes brain plasticity and is associated with protection against cognitive impairment Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. Here we used an in vitro model of AD to investigate blood plasma from exercise-trained donors on neuronal viability, vivo rat test whether such impacts function, amyloid pathology, neurogenesis. Mouse hippocampal cells were exposed AD-like stress using amyloid-β treated collected human male...
Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions KD. We aimed to investigate mechanisms underlying development electrophysiological abnormalities murine model KD vasculitis.
Resistance training is one of the most common kind exercise used nowadays. Long-term high-intensity resistance are associated with deleterious effects on vascular adjustments. On other hand, unclear whether low-intensity (LI-RT) able to induce systemic changes in tone. Thus, we aimed evaluate chronic LI-RT endothelial nitric oxide (NO) bioavailability mesenteric artery and cardiovascular autonomic modulation healthy rats. Wistar animals were divided into two groups: exercised (Ex) sedentary...
Myocardial fibrosis leads to cardiac dysfunction and arrhythmias in heart failure with preserved ejection fraction (HFpEF), but the underlying mechanisms remain poorly understood. Here, RNA sequencing identifies Forkhead Box1 (FoxO1) signaling as abnormal male HFpEF hearts. Genetic suppression of FoxO1 alters intercellular communication between cardiomyocytes fibroblasts, alleviates diastolic relaxation, reduces arrhythmias. Targeted downregulation activated fibroblasts fibrosis, blunts...
Myrtenol is a monoterpene with multiple pharmacological activities. However, although monoterpenes have been proposed to play beneficial roles in variety of cardiac disorders, actions myrtenol the heart are not yet reported. Hence, aim this study was evaluate whether promotes cardioprotection against myocardial ischemia-reperfusion (IR) injury, and mechanisms involved these effects. Male Wistar rats were orally treated for seven consecutive days (50 mg/kg) or N-acetyl cysteine (1.200 mg/kg,...
Myocardial infarction (MI) leads to high mortality, and pharmacological or percutaneous primary interventions do not significantly inhibit ischemia/reperfusion injuries, particularly those caused by oxidative stress. Recently, research groups have evaluated several naturally occurring antioxidant compounds for possible use as therapeutic alternatives traditional treatments. Studies demonstrated that d-limonene (DL), a monoterpene of citrus fruits, possesses cardiovascular properties. Thus,...
Ginkgo biloba is the most popular phytotherapic agent used worldwide for treatment of several human disorders. However, mechanisms involved in protective actions on cardiovascular diseases remain poorly elucidated. Taking into account recent studies showing beneficial cholinergic signaling heart and hypothesis biloba-mediated neuroprotection, we aimed to investigate whether extract (GBE) promotes cardioprotection via activation a model isoproterenol-induced cardiac hypertrophy. Here, show...
Strength training has beneficial effects on kidney disease, in addition to helping improve antioxidant defenses healthy animals.To verify if strength reduces oxidative damage the heart and contralateral caused by renovascular hypertension induction surgery, as well evaluate alterations activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) endogenous enzymes.Eighteen male rats were divided into three groups (n=6/group): sham, hypertensive, trained hypertensive....
◼ ion channels membrane potentialsThe American Heart Association celebrates its 100 th anniversary in 2024.
Microglia and inflammation play a significant role in Alzheimer's disease (AD). Physical exercise peripheral signals can influence microglial activity the brain. Modulating inflammatory response brain may provide therapeutic approaches for AD.
Hypertension is a chronic disease that affects about 30% of the world's population, and physical exercise plays an important role on its non-pharmacological treatment. Anywise, dose-response fractionation throughout day demands more investigation, allowing new prescription possibilities. Therefore, this study aimed to analyze acute blood pressure (BP) kinetics after 1 h exercises BP reactivity different concurrent (CE) sessions fractioning hypertensive middle-aged women. In way, 11 women...
Evaluate the cardiorespiratory fitness (CRF) and body mass index (BMI) of schoolchildren according to cutoff points established by Fitnessgram®. Just as determine influence BMI on CRF in children propose an equation for predicting VO2max from composition. The sample consisted 288 students basic level public education city Aracaju – Sergipe Brazil, aged between 10 14 years, these, 142 were female. To evaluate 20-m shuttle run test was chosen. results variable classified accordance with...
Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate effect a hydroethanolic extract (HEE) from inner bark argyrophyllus (Euphorbiaceae) on muscle damage oxidative stress in rats after high intensity exercise. animals were divided into four groups: (i) sedentary group (SV; n = 7), (ii) exercise vehicle (EV, (iii) HEE (SHG; 7) composed treated with C. (200 mg/kg, v.o.), (iv) (HEE;...
Several pathological conditions predict the use of glucocorticoids for management inflammatory response; however, chronic or high dose glucocorticoid treatment is associated with hyperglycemia, hyperlipidemia, and insulin resistance can be considered a risk factor cardiovascular disease. Therefore, we investigated mechanisms involved in vascular responsiveness profile mesenteric arteries rats treated doses glucocorticoids. Wistar were divided into control (CO) group dexamethasone (DEX)...
Diosmin is a citrus flavonoid with broad biological activities. Moreover, the administration of biologically active compounds during myocardial reperfusion potentiates cardioprotection and survival rate. Hence, this study aimed to evaluate whether diosmin elicits protection ischemic hearts investigate mechanisms involved in these effects. Male Wistar rats were subjected ischemia-reperfusion (I/R) injury presence or absence (0.1 μM). When appropriated, non-selective nitric oxide synthase...
Aim: To evaluate the subacute effects of number Pilates exercise series (one and three) on cardiovascular responses medicated hypertensive women. Methods: Eight nine normotensive women underwent a session with low high volume, were measured. Aged sample 50-65 years old to anthropometrical measurements previously experimental procedures. The assessment was performed before after every session. procedures consisted two familiarization sessions, load determination, sessions or three series) for...