A5100661237- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Axon Guidance and Neuronal Signaling
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Infectious Encephalopathies and Encephalitis
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Spinal Cord Injury Research
- Alzheimer's disease research and treatments
- Nerve Injury and Rehabilitation
- Cystic Fibrosis Research Advances
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Planarian Biology and Electrostimulation
- Hereditary Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Electromagnetic Fields and Biological Effects
- Graphene and Nanomaterials Applications
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
University of Miami
2023
D’Or Institute for Research and Education
2015-2022
Autoliv (Sweden)
2022
Hospital Universitário Clementino Fraga Filho
2014-2020
Universidade Federal do Rio de Janeiro
2009-2020
Harvard Stem Cell Institute
2014
Boston Children's Hospital
2014
Hospital Beatriz Ângelo
2013
Escola Bahiana de Medicina e Saúde Pública
2009
The mature optic nerve cannot regenerate when injured, leaving victims of traumatic damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells axons part-way through the nerve, but it remains unknown whether can reenter brain, navigate appropriate target areas, restore vision. We show here that adequate stimulation, are able full length pathway and on into lateral geniculate nucleus, superior colliculus, other...
Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury driven by degeneration, neuroinflammation, neuronal plasticity results in neuropathic pain (NP) symptoms such as allodynia hyperalgesia. We tested preventive effect an EPA/DHA-concentrate fish (CFO) on NP development regenerative features. Swiss mice received daily oral treatment with CFO 4.6 or 2.3 g/kg for...
Neurological and other systemic complications occur in adults with severe COVID-19. Here we describe SARS-CoV-2 infection complicated by neuroinvasion the post-mortem tissues of a child.We performed complete autopsy 14-month-old child who died COVID-19 pneumonitis. Histological sections multiple organs were stained haematoxylin eosin. Luxol fast blue staining for myelin immunohistochemistry selected areas brain. The presence was investigated immunostaining anti-spike protein antibody...
Abstract The stimulation of peripheral nerve regeneration has been studied in different ways, including the use electrical fields. capacity this modality to enhance is influenced by parameters used, current type, frequency, intensity, and means administration. Transcutaneous (TENS) a frequently used form administering body, but its effects on are not known. This study assessed influence TENS sciatic regeneration, using model crush lesion mouse. Mice were stimulated 30 min day, 5 days week,...
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including brain. Neurological manifestations such stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but neurotropic potential virus still debated. Herein, we sought to investigate SARS-CoV-2 human neural cells. We demonstrated tissue non-permissive, it can elicit inflammatory...
Background Despite the regenerative potential of peripheral nervous system, severe nerve lesions lead to loss target-organ innervation, making complete functional recovery a challenge. Few studies have given attention combining different approaches in order accelerate process. Objective Test effectiveness Schwann-cells transplantation into biodegradable conduit, with treadmill training as therapeutic strategy improve outcome repair after mouse injury. Methods Sciatic transection was...
We studied the morphology and cortical representation of median nerve (MN), 10 weeks after a transection immediately followed by treatment with tubulization using polycaprolactone (PCL) conduit or without bone marrow-derived mesenchymal stem cell (MSC) transplant. In order to characterize cutaneous MN inputs in primary somatosensory cortex (S1), electrophysiological mapping forepaw adjacent body parts was performed acute lesion all brachial plexus nerves, except for MN. This ten adult male...
Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles situ have not been well described, raising controversy about how causes neurological symptoms. Here, we report autopsy findings 1-year old infant with COVID-19. In addition to pneumonitis, meningitis multiple organ damage related thrombosis, previous...
Abstract The use of electromagnetic fields has been reported to enhance peripheral nerve regeneration. This study aimed identify the effects a prolonged protocol low‐frequency pulsed field (PEMF) on Thirty‐four male Swiss mice ( Mus musculus ) were divided into PEMF n = 17) and control groups. All animals underwent unilateral sciatic‐crush lesion, group was exposed 72‐Hz, 2‐G for 30 min, five days week, three weeks. Functional analysis carried out weekly. After weeks, euthanized,...
The regenerative capacity of CNS tracts has ever been a great hurdle to medicine. Although recent studies have described strategies stimulate retinal ganglion cells (RGCs) regenerate axons through the optic nerve, it still remains be elucidated how these therapies modulate inhibitory environment CNS. Thus, present work investigated environmental content repulsive axon guidance cues, such as Sema3D and its receptors, myelin debris, astrogliosis, within regenerating nerve mice submitted...
Preventing damage caused by nerve degeneration is a great challenge. There growing body of evidence implicating extracellular nucleotides and their P2 receptors in many pathophysiological mechanisms. In this work we aimed to investigate the effects administration Brilliant Blue G (BBG) Pyridoxalphosphate-6-azophenyl-2', 4'- disulphonic acid (PPADS), P2X7 non-selective receptor antagonists, respectively, on sciatic regeneration. Four groups mice that underwent crush lesion were used: two...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can infect several organs, especially impacting capacity. Among the extrapulmonary manifestations of COVID-19 myocardial injury, associated with a high risk mortality. Myocardial directly or indirectly SARS-CoV-2 infection, be triggered inflammatory processes that lead to damage heart tissue. Since one hallmarks “cytokine storm”, strategies control inflammation infection have...
Although the peripheral nervous system has an inherent capacity for regeneration, injuries to nerves still result in considerable disabilities. The persistence of these disabilities along with problem nerve reconstruction motivated neuroscientists worldwide seek additional therapeutic strategies. Here we discuss trauma terms its molecular aspects and clinical implications particular emphasis on current strategies using gene therapy. Experimental models lesions have been developed study...
Abstract Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including brain. Neurological manifestations such stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but neurotropic potential virus still debated. Herein, we sought to investigate SARS-CoV-2 human neural cells. We demonstrated tissue non-permissive, it can elicit...