A5026287847- Pain Mechanisms and Treatments
- Trace Elements in Health
- Biochemical effects in animals
- Pharmacology and Obesity Treatment
- Nerve injury and regeneration
- Herbal Medicine Research Studies
- Neuropeptides and Animal Physiology
- Synthesis of β-Lactam Compounds
- Antiplatelet Therapy and Cardiovascular Diseases
- Muscle metabolism and nutrition
- Medicinal Plants and Neuroprotection
- Protein Hydrolysis and Bioactive Peptides
- Ion Channels and Receptors
Universidade Federal do Rio de Janeiro
2011-2023
Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury driven by degeneration, neuroinflammation, neuronal plasticity results in neuropathic pain (NP) symptoms such as allodynia hyperalgesia. We tested preventive effect an EPA/DHA-concentrate fish (CFO) on NP development regenerative features. Swiss mice received daily oral treatment with CFO 4.6 or 2.3 g/kg for...
LASSBio-1135 is an imidazo[1,2-a]pyridine derivative with high efficacy in screening models of nociception and inflammation, presumed as a weak COX-2 inhibitor. In order to tease out its mechanism action, we investigated others possible target for LASSBio-1135, such TNF-α TRPV1, better characterize it multitarget compound useful the treatment chronic pain. TRPV1 modulation was assessed TRPV1-expressing Xenopus oocytes against capsaicin low pH-induced current. Modulation production evaluated...
Zinc (Zn) is an essential micronutrient involved in the physiology of nervous system and pain modulation. There little evidence for role nutritional Zn alternations to onset progression neuropathic (NP) inflammatory pain. The study investigated effects a zinc restricted diet on development Weaned mice were submitted regular (38 mg/kg Zn) or deficient (11 diets four weeks, responses evaluated (mechanical, cold heat allodynia; formalin- carrageenan-induced hypernociception), plasma tissues...
We describe herein the discovery of (E)-N-methyl-N'-((5-nitrofuran-2-yl)methylene)benzo[d] dioxole-5-carbohydrazide (9e), named LASSBio-1215, as a novel antiplatelet agent belonging to N-methyl-N-acylhydrazone class, which exert their antiaggregating actions on human and rabbit platelets induced by different agonists, through cyclooxygenase-1 (COX-1) or thromboxane synthase inhibition. This compound was elected after screening series functionalized furyl N-acylhydrazone derivatives,...
Neuropathic pain is a condition with varying origins, including reduced dietary micronutrient intake. Phytate polyphosphate found in seeds and grains that can act as an antinutrient due to the ability of sequester essential divalent metals. Here we tested whether moderate phytate intake could alter nociceptive pain. We subjected weaning mice chow supplemented 1% for eight weeks. Body weight gain, glycemic responses, food ingestion, water liver adipose tissue weights were not altered compared...
Abstract Zinc (Zn) is an essential micronutrient involved in a large diversity of cellular metabolism, included the physiology nervous system and pain modulation. There little evidence for role Zn nutritional alternations to onset progression neuropathic inflammatory pain. We investigate effects zinc restricted diet on development Weaned mice were submitted different diets: AIN-93 (38mg/kg Zn) Zn-deficient (AIN-93 with 11mg/kg Zn), during four weeks. Mechanical allodynia was measured weekly...