A5045459148- Synthesis and biological activity
- Synthesis and Reactions of Organic Compounds
- Inflammatory mediators and NSAID effects
- Pain Mechanisms and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical synthesis and pharmacological studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Phytochemistry Medicinal Plant Applications
- Click Chemistry and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Synthesis of heterocyclic compounds
- Synthesis of β-Lactam Compounds
- Oral microbiology and periodontitis research
- Multicomponent Synthesis of Heterocycles
- Synthesis and Reactivity of Heterocycles
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activity of medicinal plants
- Synthesis of Organic Compounds
- Neuroscience and Neuropharmacology Research
- Quinazolinone synthesis and applications
- Phytochemistry and Biological Activities
- Bee Products Chemical Analysis
- Plant chemical constituents analysis
Universidade Federal do Rio de Janeiro
2013-2024
National Institutes of Health
2023
Centro Hospitalar Lisboa Norte
2014-2021
Joint Research Centre
2021
Universidad Michoacana de San Nicolás de Hidalgo
2018
Instituto Português de Oncologia Francisco Gentil
2016
Conference Board
2008
Hy-Line (United States)
2008
Universidad Autónoma de Madrid
1977
Hospital Universitario Puerta de Hierro Majadahonda
1975-1977
Abstract Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows correlation between the levels vitamin in patients infected with SARS-CoV-2 degree disease severity. This work investigates impact genetic background pathways on COVID-19 For first time, Portuguese population was characterized regarding prevalence high variants associated pathways. study enrolled 517 admitted two tertiary hospitals. The serum...
Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury driven by degeneration, neuroinflammation, neuronal plasticity results in neuropathic pain (NP) symptoms such as allodynia hyperalgesia. We tested preventive effect an EPA/DHA-concentrate fish (CFO) on NP development regenerative features. Swiss mice received daily oral treatment with CFO 4.6 or 2.3 g/kg for...
Stomach cancer belongs to the most common malignant tumors in Portugal. Main causal factors are age, dietary habits, smoking, and Helicobacter pylori infections. As these do not only operate on different time dimensions, such as period, or birth cohort, but may also vary along space, it is of utmost interest model temporal spatial trends jointly. In this paper, we analyze incidence stomach Southern Portugal between 1998 2006 for females males jointly using a multivariate age‐period‐cohort...
Evidence suggests that translocation of oral pathogens through the oral-gut axis may induce intestinal dysbiosis. This study aimed to evaluate impact a highly leukotoxic Aggregatibacter actinomycetemcomitans (Aa) strain on gut microbiota, mucosal integrity and immune system in healthy mice.
ANTIINFLAMMATORY AND ANTITHROMBOTIC DRUGS.In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization two 5lipoxigenase inhibitors, e.g.CBS-1108 and BW-755c.The analgesic, antiedematogenic anti-platelet aggregating profile several isosteric compounds was investigated using classic pharmacological assays in vivo ex-vivo, allowing to identify potent peripheric analgesic...
THE Cassia GENUS.Species of are widely distributed in tropical and subtropical regions throughout the world, have been extensively investigated chemically pharmacologically.They known to be a rich source phenolic derivatives, most them with important biological pharmacological properties.Some Asian, African Indian tribes use these species as laxative, purgative, antimicrobial, antipyretic, antiviral anti-inflammatory agent.Among number other classes secondary metabolites, such anthracene...
The leaf essential oil of Eugenia uniflora L. (Myrtaceae) was extracted by Clevenger apparatus and analysed gas chromatography-mass spectrometry (GC-MS). leaves were collected immediately for five consecutive days at 9:00 am 2:00 pm. No variance in the yields observed period. Furanodiene its rearrangement product, furanoelemene (or curzerene, 50.2%), beta-elemene (5.9%) alpha-cadinol (4.7%) identified as most abundant compounds. GC-Olfatometry (GC-O) associated to Aroma Extract Dilution...
Abstract Background The coronavirus disease COVID-19 pandemic posed a number of challenges to the oncology community, particularly diagnosis and care cancer patients while ensuring safety from virus for both professionals: minimization visits hospital, cancellation screening programmes difficulties in management operation registries (CRs) working remotely. This article describes effects medium term first wave on registration Europe, focusing changes detection treatment, possible reduction CR...