A5019682884- Research on Leishmaniasis Studies
- Phagocytosis and Immune Regulation
- Trypanosoma species research and implications
- Parasites and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Oral microbiology and periodontitis research
- Fungal Infections and Studies
- Erythrocyte Function and Pathophysiology
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Plant Pathogens and Fungal Diseases
- Apelin-related biomedical research
- Antifungal resistance and susceptibility
- Invertebrate Immune Response Mechanisms
- Long-Term Effects of COVID-19
- Dental Health and Care Utilization
- Macrophage Migration Inhibitory Factor
- Immune responses and vaccinations
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Cell Function and Interaction
Universidade Federal do Rio de Janeiro
2014-2024
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2024
Czech Academy of Sciences, Institute of Microbiology
2020-2023
We investigated early cellular responses induced by infection with Leishmania major in macrophages from resistant C57/BL6 mice. Infection increased production of reactive oxygen species resident, but not inflammatory peritoneal macrophages. In addition, activation stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) also expression membrane and soluble FasL, infected remained viable after 48 h. secretion cytokines/chemokines TNF-α, IL-6, TIMP-1, IL-1RA, G-CSF, TREM, KC,...
Evidence suggests that translocation of oral pathogens through the oral-gut axis may induce intestinal dysbiosis. This study aimed to evaluate impact a highly leukotoxic Aggregatibacter actinomycetemcomitans (Aa) strain on gut microbiota, mucosal integrity and immune system in healthy mice.
Abstract Background Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of immune system causing an excessive inflammation including cytokine storm. Methods In this study, we report that acutely infected patients have high levels both type-1 type-2 cytokines. Results Our results show abnormal upon T-cell stimulation, in a nonpolarized profile. Furthermore, our findings indicate hyperactive response associated...
Abstract Adaptive immunity controls Trypanosoma cruzi infection, but the protozoan parasite persists and causes Chagas disease. T cells undergo apoptosis, efferocytosis of apoptotic might suppress macrophages exacerbate infection. Nonetheless, receptors involved in lymphocytes during infection remain unknow. Macrophages phagocytose by using TAM (Tyro3, Axl, Mer) family receptors. To address how affects macrophage-mediated immunity, we employ here Axl receptor- Mer receptor-deficient mouse...
Introduction TAM receptor-mediated efferocytosis plays an important function in immune regulation and may contribute to antigen tolerance the lungs, a site with continuous cellular turnover generation of apoptotic cells. Some studies have identified failures as common driver inflammation tissue destruction lung diseases. Our study is first characterize vivo receptors, Axl MerTk, innate cell compartment, cytokine chemokine production, well alveolar macrophage (AM) phenotype different settings...
Trypanosoma cruzi infects and replicates within a wide variety of immune non-immune cells. Here, we investigated early cellular responses induced in NIH-3T3 fibroblasts upon infection with trypomastigote forms T. cruzi. We show that were susceptible to started release trypomastigotes the culture medium after 4 days infection. Also, found reduced number 3-day cell cultures, by altering fibroblast proliferation. Infected displayed distinctive phenotypic alterations, including enlarged...
Fungal infections are the most common secondary in debilitated individuals a state of chronic disease or immunosuppression. Despite this, fungal neglected, mainly due to lower frequency their more severe clinical forms immunocompetent with healthy background. However, over past few years, several cases have provoked change epidemiological dynamics around world, both recurrent outbreaks previously infrequent regions and greater emergence pathogenic variants affecting individuals, such as...
The SARS-CoV-2 pandemic has had a social and economic impact worldwide, vaccination is an efficient strategy for diminishing those damages. New adjuvant formulations are required the high vaccine demands, especially that induce Th1 phenotype. Herein we assess using combination of Alum polyinosinic:polycytidylic acid [Poly(I:C)] adjuvants plus spike protein in prefusion trimeric conformation by intradermal (ID) route. We found levels IgG anti-spike antibodies serum enzyme linked immunosorbent...
<title>Abstract</title> In this study, we explore the adaptive mechanisms through which tick <italic>Rhipicephalus microplus </italic>can deal with a period of starvation, using as model BME26 cell line. Our findings reveal that these cells not only exhibit an impressive ability to withstand starvation but also undergo subtle structural changes in response nutritional restriction. Additionally, our assessment glycogen levels demonstrates significant drop fasting, both at 24-hour and 48-hour...
Ticks are hematophagous ectoparasites that transmit pathogens and inflict significant economic losses on the cattle industry. Remarkably, they can survive extended periods of starvation in absence a host. The primary objective this study was to investigate metabolic adaptations enable tick Rhipicephalus microplus endure using BME26 cell line as model system. To simulate nutrient deprivation, cells were subjected conditions by replacing L-15 culture medium with phosphate-buffered saline...
Abstract The SARS-CoV-2 pandemic has had a social and economic impact worldwide, vaccination is an efficient strategy for diminishing those damages. New adjuvant formulations are required the high vaccine demands, especially that induce Th1 phenotype. Herein we assess using combination of Alum polyinosinic:polycytidylic acid (Poly(I:C)) adjuvants plus spike protein in prefusion trimeric conformation by intradermal (ID) route. We found levels IgG anti-spike antibodies serum enzyme linked...
Abstract Efferocytosis is paramount to regulating homeostasis and inflammation. The TAM receptor family (Tyro3, Axl MerTk) mediates efferocytosis simultaneously inhibits pro-inflammatory pathways. Here we investigated how MerTk regulate pulmonary mucosa inflammation, using silicosis as a study model. During homeostasis, lung cells alveolar macrophages (AMs) from wild-type (WT) mice showed high expression of Axl, MerTk, Gas6. Although have found increased numbers total airway cells, lower...
Abstract Alveolar macrophages (AMs) are key cells for the establishment of pulmonary homeostasis. Efferocytosis is one main regulatory mechanisms maintaining tolerance and The TAM receptor family (Tyro3, Axl MerTk) mediates efferocytosis inhibits proinflammatory pathways through Gas6 or Protein S binding to phosphatidylserine on apoptotic cells. Here we investigated how lung regulated by receptors in homeostasis during silicosis. We found that LPS-stimulated AMs have an impaired ability...