A5063166816- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Myasthenia Gravis and Thymoma
- Growth Hormone and Insulin-like Growth Factors
- Cell Adhesion Molecules Research
- Muscle Physiology and Disorders
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- Parasites and Host Interactions
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- Axon Guidance and Neuronal Signaling
- Toxin Mechanisms and Immunotoxins
- Lymphatic System and Diseases
- Adenosine and Purinergic Signaling
- Receptor Mechanisms and Signaling
- Mesenchymal stem cell research
- Skin and Cellular Biology Research
- Signaling Pathways in Disease
- Connexins and lens biology
Fundação Oswaldo Cruz
2016-2025
Faculdades Oswaldo Cruz
1989-2024
Universidade Federal de Santa Catarina
2024
NIHR Clinical Research Network
2024
Oxford BioMedica (United Kingdom)
2024
Oxford Biomedical Research
2024
Serviço Nacional de Aprendizagem Industrial
2024
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2020-2023
Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular
2019-2023
University of Turin
2016
The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection threatening millions. majority of the individuals infected are asymptomatic or mildly symptomatic showing typical clinical signs common cold. However, approximately 20% patients can progress to acute respiratory distress syndrome (ARDS), evolving death in about 5% cases. Recently, angiotensin-converting enzyme 2 (ACE2) has been shown be functional receptor for virus entry into host target cells....
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). The impacts of may be beyond respiratory system, also affecting mental health. Several factors involved in association between COVID-19 and psychiatric outcomes, such as fear inherent pandemic, adverse effects treatments, well financial stress social isolation. Herein we discuss growing evidence suggesting that relationship SARS-CoV-2 host trigger changes brain behavior. Based on similarity...
Molecular cloning of components protective antigenic preparations has suggested that related parasite fatty acid-binding proteins could form the basis immune crossreactivity between parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. models two showed both molecules adopt same basic three-dimensional structure, consisting a barrel-shaped molecule formed by 10 antiparallel beta-pleated strands joined short loops, revealed likely presence crossreactive, discontinuous epitopes...
Macrophages have been shown to be essential for muscle repair by delivering trophic cues growing skeletal precursors and young fibers. Here, we investigated whether human macrophages, either proinflammatory or anti-inflammatory, coinjected with myoblasts into regenerating of Rag2(-/-) γC(-/-) immunodeficient mice, could modify in vivo the kinetics proliferation differentiation transplanted myogenic precursors. Our results clearly show that macrophages improve participation injected host...
The contribution of autoimmunity in the genesis chronic Chagas' heart pathology is not clear. In present study, we show that: (a) BALB/c mice chronically infected with Trypanosoma cruzi reject syngeneic newborn hearts; (b) vivo treatment anti-CD4 but anti-CD8 monoclonal antibodies (mAbs) abrogates rejection; (c) CD4+ T cells from proliferate vitro to myocardium antigens and induce graft destruction when injected situ; (d) establishes long-term tolerance grafts; (e) state related...
We have investigated the role of GH and insulin-like growth factor-I (IGF-I) in controlling secretion thymulin, a hormone produced by thymic epithelial cells (TEC). Thymulin plasma concentrations (mean +/- SD) were increased 21 patients with acromegaly compared to those 30 controls, as assessed bioassay (4.24 0.97 vs. 2.67 0.87; P less than 0.001) RIA (561 241 315 113 pg/L; 0.01). Good correlations observed between levels thymulin IGF-I (P 0.001). In vitro experiments demonstrated that both...
The characterization and distribution of cells containing the serum thymic factor (FTS) in thymus young mice was studied by immunofluorescence using monoclonal anti-FTS antibodies. FTS+ were distributed throughout parenchyma but more frequent medullary region than cortex. FTS-containing presented a stellate or globular aspect, some them exhibited fluorescent cytoplasmic granules. epithelial nature confirmed double-labeling experiments an anti-keratin antiserum (as cell marker). Nevertheless,...
It is largely established that molecules first discovered in the nervous system are also found immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and involved peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 human thymus. expressed both cortex medulla of thymic lobules, being distinct CD4/CD8-defined thymocyte subsets. epithelial cells (TEC) situ vitro , recruited at site TEC–thymocyte...
Oral transmission of Trypanosoma cruzi, the causative agent Chagas disease, is most important route infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed importance parasite contact oral cavity to induce a highly severe acute disease mice. However, it remains uncertain primary site entry multiplication due an infection. Here, we evaluated presence T. cruzi Dm28c luciferase (Dm28c-luc)...
Oral transmission of Chagas disease has been documented in Latin American countries. Nevertheless, significant studies on the pathophysiology this form infection are largely lacking. The few investigating oral route disregard that inoculation cavity (Oral infection, OI) or by gavage (Gastrointestinal GI) represent different routes, yet both show clear-cut parasitemia and heart parasitism during acute infection. Herein, BALB/c mice were subjected to OI GI using 5x10(4) culture-derived...
The present investigation was an ontogenetic study on the distribution of extracellular matrix (ECM) components in thymic microenvironment C57BL/6 mice (comprising young and old adults developing embryos) NZB mice. In addition, we evaluated vivo vitro influence hydrocortisone treatment basement membrane protein production by a epithelial cell line. normal animals, Type I collagen restricted to interstitial spaces capsule septa, where IV collagen, fibronectin, laminin could be detected...
Abstract The localization of the three best‐defined thymic hormones, namely, thymulin, thymopoietin and thymosin α1 was studied by immunofluorescence using antibodies directed against these molecules. With both human thymus frozen sections cultured cells, hormones were found exclusively in epithelial component (recognized its keratin content), normal as well pathological thymuses. double‐labeling experiments different anti‐thymic hormone showed that same cells contained hormones. These...