Victor A. R. Pereira
A5064269247- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Paraoxonase enzyme and polymorphisms
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Apelin-related biomedical research
- vaccines and immunoinformatics approaches
- Exercise and Physiological Responses
Universidade Federal do Rio de Janeiro
2020-2022
National Institute of Science and Technology for Structural Biology and Bioimaging
2020-2022
Universidade Estadual de Maringá
2019
Hospital de Faro EPE
2013
We used the recombinant trimeric spike (S) glycoprotein in prefusion conformation to immunize horses for production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by ELISA were above 1:10
To evaluate the association of different apelin levels with cardiovascular mortality, hospitalization, renal function, and risk factors in type 2 diabetic patients mild to moderate CKD. An observational, prospective study involving 150 divided into groups according baseline levels: 1 ≤ 98 pg/mL, = 98-328 3 ≥ 329 pg/mL. Baseline characteristics were analyzed compared. Multivariate Cox regression was used find out predictors multivariate logistic hospitalization disease progression. Simple...
Abstract We used the trimeric spike (S) glycoprotein (residues 1-1208) in prefusion conformation to immunize horses for production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by anti-spike ELISA were above 1:1,000,000, and neutralizing titer was 1:14,604 (average PRNT 90 ), which is 140-fold higher than average plasma from three convalescent COVID-19 patients analyzed comparison. Using same technology routinely industrial other horse products, immunized...
Despite the intramuscular route being most used vaccination strategy against SARS-CoV-2, intradermal has been studied around globe as a strong candidate for immunization SARS-CoV-2. Adjuvants have shown to be essential vaccine components that are capable of driving robust immune responses and increasing efficacy. In this work, our group aimed develop SARS-CoV-2 using trimeric spike protein, by testing best with formulations containing adjuvants AddaS03, CpG, MPL, Alum, or combination two...
The SARS-CoV-2 pandemic has had a social and economic impact worldwide, vaccination is an efficient strategy for diminishing those damages. New adjuvant formulations are required the high vaccine demands, especially that induce Th1 phenotype. Herein we assess using combination of Alum polyinosinic:polycytidylic acid [Poly(I:C)] adjuvants plus spike protein in prefusion trimeric conformation by intradermal (ID) route. We found levels IgG anti-spike antibodies serum enzyme linked immunosorbent...
Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as also leads the liver adipose tissue an anabolic state, purpose of this study was investigate effects on metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treated with saline (SS) or (SI) (TS) (TI). Training made a vertical stair, at 90% maximum load, three times per week. Insulin (0.3 U/kg body weight) given intraperitoneally five After...
The cardiac plexus is a vast network of neurons grouped into ganglia distributed throughout the myocardium. epicardial adipose tissue covers heart performing important functions, such as, lipid storage. However, its exaggerated expression might represent risk factor, which can be prevented by practice physical activities that improves contractile propulsive capacity. Insulin has been used in association with exercise so as to increase muscle mass and improve performance. Both insulin have...
Abstract The SARS-CoV-2 pandemic has had a social and economic impact worldwide, vaccination is an efficient strategy for diminishing those damages. New adjuvant formulations are required the high vaccine demands, especially that induce Th1 phenotype. Herein we assess using combination of Alum polyinosinic:polycytidylic acid (Poly(I:C)) adjuvants plus spike protein in prefusion trimeric conformation by intradermal (ID) route. We found levels IgG anti-spike antibodies serum enzyme linked...
step methodology .
We used the trimeric spike (S) glycoprotein (residues 1-1208) in prefusion conformation to immunize horses for production of hyperimmune globulins against SARS-CoV-2. Serum antibody titers measured by anti-spike ELISA were above 1:106, and neutralizing titer an early isolate authentic virus (WT) was 1:14,604 (average PRNT90), which is 140-fold higher than average plasma from three convalescent COVID-19 patients analyzed comparison. Using same technology routinely industrial other horse...