A5080373836- Analytical Methods in Pharmaceuticals
- Water Treatment and Disinfection
- Proteoglycans and glycosaminoglycans research
- Synthesis and biological activity
- Advanced Chemical Sensor Technologies
- Healthcare Regulation
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Intramuscular injections and effects
- Antibiotics Pharmacokinetics and Efficacy
- Public Health and Environmental Issues
- Cardiovascular and exercise physiology
- Synthesis of Organic Compounds
- GABA and Rice Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Membrane-based Ion Separation Techniques
- Cannabis and Cannabinoid Research
- Inflammatory mediators and NSAID effects
- Sulfur Compounds in Biology
- Virology and Viral Diseases
- Healthcare during COVID-19 Pandemic
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bioactive Compounds and Antitumor Agents
- Pesticide Residue Analysis and Safety
- Analytical chemistry methods development
Fundação Oswaldo Cruz
2016-2023
Universidade Federal do Rio de Janeiro
2000-2003
This study was designed to investigate the effects on single skeletal muscle fibers of a novel thienylhydrazone, referred as LASSBio-294, which is bioisoster pyridazinone compounds that inhibit cyclic AMP-specific phosphodiesterase (PDE) 4. Twitch and fatigue were analyzed in isolated from either semitendinous or tibialis anterior muscles dissected frog Rana pipiens. LASSBio-294 (12.5-100 microM) increased twitch tension, accelerated maximal rate tension decay during relaxation, had very...
Article SYNTHESIS, BIOLOGICAL EVALUATION, AND STRUCTURAL STUDIES OF 3-PHENYL[ 1,2,4]OXADIAZOLE-5-CARBOXYLIC ACID BENZO[1,3]DIOXOL 5-YLMETHYLENE-HYDRAZIDE was published on February 1, 2005 in the journal Heterocyclic Communications (volume 11, issue 1).
Os comprimidos utilizados no tratamento da tuberculose possuem quatro fármacos associados, isoniazida, pirazinamida, etambutol e rifampicina, são distribuídos gratuitamente pelo Sistema Único de Saúde. métodos analíticos oficiais para analisar este medicamento estão especificados na Farmacopeia Americana 36a edição Internacional 4a edição. Porém, estes compêndios não monografias análise simultânea dos fármacos. O objetivo deste estudo foi desenvolver uma metodologia determinar...
Diante da pandemia decretada pela Organização Mundial Saúde devido ao avanço mundial Covid-19 e sua rápida disseminação gravidade, a cloroquina surgiu como um possível protocolo de tratamento doença principalmente em pacientes com casos graves hospitalizados. A é medicamento empregado no malária, artrite reumatoide lúpus, mas também apresenta atividades antivirais anti-inflamatórias, demonstrando ter uma eficácia potente pneumonia por Covid-19. segurança, qualidade dos medicamentos...
N-nitrosamines (NA) impurities have unexpectedly been found in sartan products, an angiotensin II receptor antagonists that are used to control hypertension, representing urgent concern for industry and global regulators. In this study, HPLC-MS/MS method was developed validated the quantification of six NA (N-nitrosodimethylamine, N-Nitroso-N-methyl-4-aminobutyric acid, N-Nitrosodiethylamine, N-ethyl-N-nitroso-2-propanamine, N-nitroso-diisopropylamine N-nitroso-di-n-butylamine) losartan,...
Introduction: Research, one of the core areas health surveillance, has its importance justified by search for answers to various problems. Heparin, a biological product with anticoagulant and antithrombotic properties, been related adverse events between years 2007–2008. Because that, official compendiums updated monograph raw material. However, there is lack monographs that evaluate final product. Objective: The goal this study propose physicochemical method analysis limits galactosamine in...
Abstract For see ChemInform in Full Text.
O Estudo de Degradação Forçada (EDF) em medicamentos é um processo que resulta na formação produtos degradação quando o insumo farmacêutico ativo, isoladamente e forma farmacêutica, exposto às condições forçadas estresse mais extremas do Estabilidade longa duração. Medicamentos contendo metronidazol são essenciais disponibilizados pelo Sistema Único Saúde. principal objetivo deste trabalho avaliar a decaimento condição oxidativa utilizando H2O2 15% como agente degradante. Neste foi avaliado...
Impurezas de N-nitrosaminas (NA), conhecido potencial carcinogênico, têm sido motivo preocupação para a indústria farmacêutica e agências reguladoras em vários países nos últimos anos. NA foram inesperadamente identificadas medicamentos controle da hipertensão arterial, as sartanas. Nosso principal objetivo é destacar os riscos presença dessas impurezas delinear como autoridades sanitárias, todo o mundo, realizaram revisões regulatórias onde estabelecidas novas resoluções implementações...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Early studies suggesting that chloroquine (CQ) and hydroxychloroquine (HCQ) could benefit coronavirus patients brought these old medicines back to the spotlight. This led an increase in demand price, turning their counterfeiting a pharmacovigilance issue worldwide. Meanwhile, lack of evidence on effectiveness safety concerns have reduced clinical trials severe COVID-19 cases. Despite knowledge CQ HCQ toxic effects are stereo specific rather than therapeutic effects, drugs available only as...