A5029206728- Marine Biology and Environmental Chemistry
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adipokines, Inflammation, and Metabolic Diseases
- Chemotherapy-induced organ toxicity mitigation
- Apelin-related biomedical research
- Regulation of Appetite and Obesity
- Exercise and Physiological Responses
- Hypothalamic control of reproductive hormones
- Muscle metabolism and nutrition
- Antioxidant Activity and Oxidative Stress
- Hormonal Regulation and Hypertension
- Ovarian function and disorders
- Renin-Angiotensin System Studies
- Growth Hormone and Insulin-like Growth Factors
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Stress Responses and Cortisol
- Genetic Syndromes and Imprinting
- Pomegranate: compositions and health benefits
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
Universidade Federal de São Paulo
2019-2025
The University of Texas at San Antonio
2024
The University of Texas Health Science Center at San Antonio
2024
Universidade Federal do Espírito Santo
2010-2023
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2023
Max Delbrück Center
2019-2022
Universidade Federal de Minas Gerais
2015-2019
Tributyltin chloride (TBT) is an environmental contaminant that used as a biocide in antifouling paints. TBT has been shown to induce endocrine-disrupting effects. However, studies evaluating the effects of on hypothalamus-pituitary-adrenal (HPA) axis are especially rare. The current study demonstrates exposure critically responsible for improper function mammalian HPA well development abnormal morphophysiology pituitary and adrenal glands. Female rats were treated with TBT, their was...
Based on the antioxidant properties of pomegranate, this study was designed to investigate effects pomegranate peel extract damage associated with hypertension and aging in a spontaneously hypertensive rat (SHR) model. The influence consumption examined systolic blood pressure (SBP), angiotensin-converting enzyme (ACE) coronary activity, oxidative stress, vascular morphology. Four- or 28-wk-old SHR model rats were treated for 30 d, terminal experimental animal age being 8 32 wk,...
Cocaine- and amphetamine-regulated transcript peptide (CARTp) is an anorexigenic neuropeptide whose receptor undisclosed. Previously, we reported the specific binding of CART(61-102) to pheochromocytoma PC12 cells, where affinity number sites per cell corresponded ligand-receptor binding. Recently, Yosten et al. designated orphan GPR160 as CARTp receptor, because antibody abolished neuropathic pain effects induced by CART(55-102) exogenous coimmunoprecipitated with in KATOIII cells. As no...
Abstract Aims To evaluate the molecular mechanisms involved in intermittent fasting 16/8 (16/8 IF), a widespread dietary practice adopted worldwide that consists of 16 h and 8 feeding. Methods Obese mice were fasted daily from 6 am to 10 pm. Food intake, body weight, energy expenditure measured. Molecular investigated using ELISA, western blot, qPCR white brown adipose tissues. Glucose homeostasis was also evaluated. Ucp1 knockout ob/ob utilized. Results The IF regimen improved glucose...
The molecular mechanisms regulating the zonal distribution of metabolism in liver are incompletely understood. Here we use single nuclei genomics techniques to examine spatial transcriptional function transcription factor 7-like 2 (TCF7L2) mouse liver, and determine consequences TCF7L2 inactivation on metabolic architecture zonated pathways. We report that while Tcf7l2 mRNA expression is ubiquitous across lobule, accessibility consensus TCF/LEF DNA binding motif restricted pericentral (PC)...
Abstract Background Although advanced age is considered a risk factor for several diseases, the impact of gender on age-associated cardiovascular such as atherosclerotic processes and valvular remains not completely clarified. The present study was designed to assess aortic valve morphology function vascular damage in elderly using apolipoprotein E knockout (ApoE KO) mouse. Our hypothesis that age-related changes are aggravated male mice. Methods grade (0 4) regurgitation evaluated through...
Tributyltin chloride (TBT) is an organometallic pollutant that used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of on renal function are rare. This study demonstrates exposure responsible for improper well development abnormal morphophysiology mammalian kidneys. Female rats were treated with TBT, their was assessed. Morphophysiological abnormalities such decreased glomerular filtration rate increased...
Cisplatin is a chemotherapy drug widely used in the treatment of solid tumors. However, nephrotoxicity has been reported about one-third patients undergoing cisplatin therapy. Proximal tubules are main target toxicity and cellular uptake; elimination this can modulate renal damage. Organic transporters play an important role transport into kidney organic cations transporter 2 (OCT-2) shown to be one most role. On other hand, multidrug toxin extrusion 1 (MATE-1) protein that mediates urine....
Abstract Background Stem/progenitor cell-based therapy has successfully been used as a novel therapeutic strategy for vascular diseases triggered by endothelial dysfunction. The aim of this study was to investigate the effects mononuclear cell (MNC) in situ on carotid cuff-induced occlusive thrombus apolipoprotein E knockout (apoE -/- ) mouse. Methods Spleen-derived MNCs were isolated from green fluorescent protein (GFP)-transgenic mice treatment. A model produced placing nonconstrictive...
Decline in estrogen levels promotes endothelial dysfunction and, consequently, the most prevalent cardiovascular diseases menopausal women. The use of natural therapies such as pomegranate can change these results. Pomegranate [Punica granatum L. (Punicaceae)] is widely used a phytotherapeutic agent worldwide, including Brazil. We hypothesized that treatment with hydroalcoholic extract (PHE) would improve coronary vascular reactivity and parameters. At beginning treatment, spontaneously...
Sclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). has been widely studied due to its anti-inflammatory and antioxidant effects.The present study aimed evaluate effects of different formulations (solid lipid nanoparticle free) on metabolic profile obese mice.Swiss male mice were randomly divided into two groups: standard diet (STD) high-fat (HFD). After obesity induction, each group was three treatment free (Sc), Sclareol-loaded...
Abstract Background Recent studies have highlighted the potential of cell therapy for atherosclerosis. The aim this study was to evaluate effects mononuclear (MNC) on development atherosclerotic lesions in apolipoprotein E knockout (apoE KO) mouse. Methods We investigated vascular lipid deposition, remodeling, oxidative stress, and endothelial nitric oxide synthase (eNOS) expression apoE KO mice treated with spleen MNCs isolated from lacZ transgenic KO-MNC) 8 weeks compared untreated control...