A5103265425- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Apelin-related biomedical research
- Pregnancy and preeclampsia studies
- GDF15 and Related Biomarkers
- Anesthesia and Pain Management
- Dietary Effects on Health
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Migraine and Headache Studies
Universidade Federal de São Paulo
2023-2025
Brigham and Women's Hospital
1986
Columbia University
1986
Harvard University
1986
Abstract Aims To evaluate the molecular mechanisms involved in intermittent fasting 16/8 (16/8 IF), a widespread dietary practice adopted worldwide that consists of 16 h and 8 feeding. Methods Obese mice were fasted daily from 6 am to 10 pm. Food intake, body weight, energy expenditure measured. Molecular investigated using ELISA, western blot, qPCR white brown adipose tissues. Glucose homeostasis was also evaluated. Ucp1 knockout ob/ob utilized. Results The IF regimen improved glucose...
Highlights•B1R controls adiponectin secretion by parametrial adipose tissue•B1KO triggers decreased maternal levels of HMW and hyperinsulinemia•Maternal B1R deficiency results in placental insulin resistance•B1KO an obesogenic intrauterine environment heavier pupsSummaryGiven the importance kinin B1 receptor leptin hormonal regulation, which turn is crucial adaptations to ensure nutrient supply fetus, we investigated role this metabolism fetoplacental development. Wild-type...