A5004070717- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Renin-Angiotensin System Studies
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Biochemical effects in animals
- Cancer, Hypoxia, and Metabolism
- Apelin-related biomedical research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Gut microbiota and health
- Head and Neck Cancer Studies
- Peroxisome Proliferator-Activated Receptors
- Nutrition, Genetics, and Disease
- Natural Antidiabetic Agents Studies
- RNA modifications and cancer
- Insect Utilization and Effects
- Tannin, Tannase and Anticancer Activities
- Cancer-related Molecular Pathways
- Phytochemicals and Antioxidant Activities
Universidade Estadual de Montes Claros
2015-2024
Universidade Federal de Minas Gerais
2015-2024
Universidade Federal de Juiz de Fora
2022
Instituto Federal de Educação Ciência e Tecnologia do Norte de Minas Gerais
2022
Universidade Estadual de Campinas (UNICAMP)
2022
Instituto de Ciencias Agrarias
2020
Administração Regional de Saúde de Lisboa e Vale do Tejo
2020
Agostinho Neto University
2017
Touro University Nevada
2013
University of Maryland, Baltimore
2013
Resveratrol (RSV) is the most studied natural compound that activates sirtuins, which produce beneficial metabolic effects on lipid and glucose metabolism. The aim of present study was to investigate role resveratrol in preventing nonalcoholic fatty liver disease (NAFLD) expression inflammatory markers mice treated with a high-fat diet.Eighteen male were divided into three groups fed for 60 d standard diet (ST), (HFD), or plus (HFD + RSV, 30 mg/kg/d). Body weight, food intake, serum total...
OBJECTIVE— Metabolic syndrome is characterized by the variable coexistence of obesity, hyperinsulinemia, insulin resistance, dyslipidemia, and hypertension. It well known that angiotensin (Ang) II importantly involved in metabolic syndrome. However, role vasodilator Ang-(1-7)/Mas axis not known. The aim this study was to evaluate effect genetic deletion G protein–coupled receptor, Mas, lipidic glycemic metabolism FVB/N mice. RESEARCH DESIGN AND METHODS— Plasma lipid, insulin, cytokine...
Mas codes for a G protein-coupled receptor that is implicated in angiotensin-(1-7) signaling. We studied the cardiovascular phenotype of Mas-deficient mice backcrossed onto FVB/N genetic background using telemetry and found they exhibit higher blood pressures compared with controls. These Mas(-/-) also had impaired endothelial function, decreased NO production, lower synthase expression. Reduced nicotinamide-adenine dinucleotide phosphate oxidase catalytic subunit gp91(phox) protein content...
Obesity and diabetes remain among the world's most pervasive health problems. Although importance of angiotensin II for metabolic regulation is well documented, role angiotensin-(1-7)/Mas axis in this process poorly understood. The aim study was to evaluate effect increased angiotensin-(1-7) plasma levels lipid glucose metabolism using transgenic rats that express an angiotensin-(1-7)-releasing fusion protein, TGR(A1-7)3292 (TGR).The TGR induced enhanced tolerance, insulin sensitivity,...
Obesity is characterized by a pro-inflammatory state commonly associated with type 2 diabetes and fat-liver disease. In the last few years, different studies pointed out role of Angiotensin (Ang)-(1-7) in metabolic regulation. The aim present study was to evaluate effect oral-administration Ang-(1-7) metabolism inflammatory high-fat feed rats. Twenty-four male Sprague Dawley rats were randomized into three groups: High Fat Diet (HFD); Standard (ST); Diet+Angiotensin-(1-7) [HFD+Ang-(1-7)]....
Angiotensin (Ang)-(1-7) has been described as an important tool on treating and preventing metabolic disorders. In this study, we aimed to evaluate the effect of oral formulation Ang-(1-7) included in hydroxypropylβ-cyclodextrin (HPβCD/Ang-[1-7]) hepatic function, steatosis, liver inflammatory markers expression mice treated with a high-fat diet. Male FVB/N were divided into 4 groups fed for 60 days, each group receiving 1 following diets: standard diet+HPβCD, diet+Ang-(1-7)/HPβCD, or...
The aim of the present study was to evaluate effect a transgenic-induced chronic increase Ang-(1–7) on expression inflammatory markers in adipose tissue and metabolic profile rats treated with high-fat diet. Transgenic expressing an Ang-(1–7)-producing fusion protein (TGR L-3292) Sprague Dawley (SD) control 4 weeks old were for 8 Food intake body weight measured once week. Glucose-tolerance insulin sensitivity tests performed one week before sacrifice. At end experiment plasma lipid...
// Talita Antunes Guimarães 1 , Lucyana Conceição Farias Eliane Sobrinho Santos 1, 5 Carlos Alberto de Carvalho Fraga 6, 7 Lissur Azevedo Orsini 2 Leandro Freitas Teles John David Feltenberger 3 Sabrina Ferreira Jesus Marcela Gonçalves Souza Sérgio Henrique Sousa 4 Alfredo Maurício Batista Paula Ricardo Santiago Gomez 2, * André Luiz Sena Department of Dentistry, Universidade Estadual Montes Claros, Minas Gerais, Brazil Clinical, Surgery and...
The present study aimed to evaluate the effects of resveratrol on FNDC5 and thermogenesis markers expression in adipose tissue mice humans. Thirty-two male were randomly divided into four groups (n = 8) fed with: Standard Diet; Diet + Resveratrol (400 mg/kg); High-fat for eight weeks. Twenty female volunteers, aged 30-55 years, BMI ≥ 30 kg/m² two treated weeks with 500 mg trans-resveratrol or placebo, biopsies taken. Analysis body weight, food intake, glycemic lipid profiles, mRNA from...