A5086200557- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Apelin-related biomedical research
- Nitric Oxide and Endothelin Effects
- Obstructive Sleep Apnea Research
- Eicosanoids and Hypertension Pharmacology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Inflammatory mediators and NSAID effects
- Airway Management and Intubation Techniques
- Public Health in Brazil
- Monoclonal and Polyclonal Antibodies Research
- Exercise and Physiological Responses
- Health, Nursing, Elderly Care
- FOXO transcription factor regulation
- scientometrics and bibliometrics research
- Prostate Cancer Treatment and Research
- Protein Kinase Regulation and GTPase Signaling
- Renal and related cancers
- Pharmacogenetics and Drug Metabolism
Universidade de Itaúna
2015-2024
Universidade Federal de Minas Gerais
2007-2022
University of Lausanne
2018
Lung Institute
2018
Imperial College London
2018
Singapore Eye Research Institute
2018
University of California, Los Angeles
2018
Agency for Science, Technology and Research
2018
Institute of Molecular and Cell Biology
2018
Nanyang Technological University
2018
Angiotensin-(1-7) [Ang-(1-7)] causes endothelial-dependent vasodilation mediated, in part, by NO release. However, the molecular mechanisms involved endothelial synthase (eNOS) activation Ang-(1-7) remain unknown. Using Chinese hamster ovary cells stably transfected with Mas cDNA (Chinese ovary-Mas), we evaluated underlying related to receptor Mas–mediated posttranslational eNOS and We further examined profile of human aortic cells, which constitutively express receptor. ovary-Mas cell were...
Angiotensin (Ang)-(1-7), acting through the Mas receptor, opposes actions of Ang II. Molecular mechanisms for this are unclear. Here we sought to determine whether Ang-(1-7) influences II signaling in human endothelial cells, focusing specifically on Src homology 2-containing inositol phosphatase 2 (SHP-2) and its interaction with c-Src. II–induced phosphorylation c-Src, extracellular signal regulated kinase (ERK)1/2, SHP-2 activation NAD(P)H oxidase were assessed absence presence (10 −6...
The systemic and regional hemodynamics effects of ANG-(1–7) were examined in urethane-anesthetized rats. blood flow distribution (kidneys, skin, mesentery, lungs, spleen, brain, muscle, adrenals), cardiac output, total peripheral resistance investigated by using fluorescent microspheres. Blood pressure heart rate recorded from the brachial artery. infusion (110 fmol · min −1 10 iv) significantly increased to kidney (5.10 ± 1.07 8.30 0.97 ml g ), mesentery (0.73 0.16 1.17 0.49 brain (1.32...
Mas codes for a G protein-coupled receptor that is implicated in angiotensin-(1-7) signaling. We studied the cardiovascular phenotype of Mas-deficient mice backcrossed onto FVB/N genetic background using telemetry and found they exhibit higher blood pressures compared with controls. These Mas(-/-) also had impaired endothelial function, decreased NO production, lower synthase expression. Reduced nicotinamide-adenine dinucleotide phosphate oxidase catalytic subunit gp91(phox) protein content...
It has been described recently that the nonpeptide AVE 0991 (AVE) mimics effects of angiotensin-(1-7) [Ang-(1-7)] in bovine endothelial cells. In this study, we tested possibility is an agonist Ang-(1-7) receptor Mas, vitro and vivo. water-loaded C57BL/6 mice, (0.58 nmol/g body weight) produced a significant reduction urinary volume (0.06+/-0.03 mL/60 min [n=9] versus 0.27+/-0.05 [n=9]; P<0.01), associated with increase osmolality. The antagonist A-779 completely blocked antidiuretic effect...
We have described a transgenic rat line that expresses an angiotensin-(1-7)-producing fusion protein, the TGR(A1-7)3292. In these rats, testis acts as angiotensin-(1-7) biological pump, increasing its plasma concentration 2.5-fold. this study, we performed hemodynamic measurements in TGR(A1-7)3292 and age-matched Hannover Sprague-Dawley (SD) control using fluorescent microspheres. Urethane-anesthetized rats had similar levels of baseline blood pressure (99 +/- 3 mmHg) did SD (101 mmHg)....
The family of angiotensin peptides has been steadily growing in recent years. Most are fragments II (Ang II) with different affinities to the known receptors. Here, we describe a novel endogenous Ang II-like octapeptide plasma from healthy humans and patients end-stage renal failure, which acts as stronger agonist at Mas receptors than 1–7. Chromatographic purification structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an...
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in inflammation and cancer targeted by nonsteroidal anti-inflammatory drugs. COX-2 also constitutively discreet locations where its inhibition drives gastrointestinal cardiovascular/renal side effects. Constitutive expression the kidney regulates renal function blood flow; however, global relevance of versus other tissues to COX-2-dependent flow regulation not known. Here, we used a microsphere deposition technique pharmacological map...
Alamandine is a heptapeptide from the renin-angiotensin system (RAS) with similar structure/function to angiotensin-(1-7) [ang-(1-7)], but they act via different receptors. It remains elusive whether alamandine an antiproliferative agent like ang-(1-7). The goal of this study was evaluate potential activity and underlying cellular signaling. We evaluated effect in tumoral cell lines Mia PaCa-2 A549, nontumoral HaCaT, CHO transfected receptor MrgD (CHO-MrgD). able reduce proliferation...
To evaluate the impact of a short-term cardiovascular physical programme on metabolic, anthropometric and oxidative stress parameters women with metabolic syndrome.Thirty sedentary female patients, age range 30-60 years, were invited to participate in 6-week programme. The training consisted 60-min sessions aerobic strength exercises performed 3 times week; total 18 sessions. Anthropometric data, functional exercise capacity, general biochemical profile, serum lipid peroxidation, superoxide...
Vários estudos destacam as espécies reativas de oxigênio e nitrogênio (ERONs) como importantes contribuintes na patogênese numerosas doenças cardiovasculares, incluindo hipertensão, aterosclerose falência cardíaca. Tais são moléculas altamente bioativas com vida curta derivadas, principalmente, da redução do molecular. O complexo enzimático NADPH oxidase é a maior fonte dessas vasculatura. Sob condições fisiológicas, formação eliminação destas substâncias aparecem balanceadas parede...
Nonsteroidal antiinflammatory drugs, including ibuprofen, are among the most commonly used medications and produce their effects by blocking cyclooxygenase (COX)-2. Their use is associated with increased risk of heart attacks caused COX-2 in vasculature and/or kidney, our recent work implicating endogenous NOS inhibitor asymmetric dimethylarginine (ADMA), a cardiotoxic hormone whose can be prevented L-arginine. The ibuprofen salt arginate (Spididol) was created to increase solubility but we...
Abstract Activation of the angiotensin (Ang)-converting enzyme (ACE) 2/Ang-(1-7)/MAS receptor pathway renin–angiotensin system (RAS) induces protective mechanisms in different diseases. Herein, we describe cardiovascular phenotype a new transgenic rat line (TG7371) that expresses an Ang-(1-7)-producing fusion protein. The transgene-specific mRNA and corresponding protein were shown to be present all evaluated tissues TG7371 with highest expression aorta brain. Plasma Ang-(1-7) levels,...
O Brasil apresenta polarização epidemiológica, com elevadas taxas de mortalidade por doenças crônicas não transmissíveis e alta incidência moléstias infectoparasitárias. As ações saúde devem ser desenvolvidas a partir da análise microrregional é essencial que o fisioterapeuta conheça cenário epidemiológico. OBJETIVO: mapear perfil socioeconômico, prevalência DCNT e/ou infectoparasitárias risco familiar. MÉTODOS: Estudo transversal, realizado à população atendida nas CIFs- UIT (parecer...
Anormalidades da anatomia orofacial estao envolvidas na patogenese AOS por facilitarem o fechamento das vias areas. O estudo objetivou associar a presenca de alteracoes orofaciais ao risco para em hipertensos. Noventa e cinco individuos (46% homens 54% mulheres, 64 ± 10 anos) foram avaliados quanto distância tireomentoniana (DTM), Mallampati, palato ogival, grau Angle, indice massa corporea (IMC), circunferencias abdominal (CA) do pescoco (CP). foi obtido pelo questionario Berlim (QB). Foram...
Introdução: Doentes renais crônicos terminais, que necessitam de diálise com regularidade podem apresentar alterações metabólicas, cardiovasculares e musculoesqueléticas. Alguns estudos demonstraram essas interferem negativamente na qualidade vida funcionalidade desses pacientes em hemodiálise. Objetivo: Realizar uma busca sistemática da literatura sobre os efeitos treinamentos aeróbicos resistidos realizados no período intradialítico a Metodologia: Realizou-se pesquisa bibliográfica nas...