A5041916478- Renin-Angiotensin System Studies
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Chronic Kidney Disease and Diabetes
- Pediatric Urology and Nephrology Studies
- Platelet Disorders and Treatments
- Urological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune Bullous Skin Diseases
- Pituitary Gland Disorders and Treatments
- scientometrics and bibliometrics research
- Science and Science Education
- Neuropeptides and Animal Physiology
- Growth Hormone and Insulin-like Growth Factors
- Vasculitis and related conditions
- Phosphodiesterase function and regulation
- Reproductive System and Pregnancy
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Apelin-related biomedical research
- Renal and related cancers
- Health and Medical Education
- Tea Polyphenols and Effects
Universidade Federal de Minas Gerais
2015-2025
Prefeitura Municipal de Belo Horizonte
2019
Hospital das Clínicas da Universidade Federal de Minas Gerais
2006-2018
Universidade do Estado de Minas Gerais
2016
Biolog (United States)
2013
Charité - Universitätsmedizin Berlin
2011
Institute of Molecular Biology and Biophysics
2008
Universidade de São Paulo
2006
Universidade Federal de São Paulo
2004
Kiel University
2004
The renin–angiotensin system plays a critical role in blood pressure control and body fluid electrolyte homeostasis. Besides angiotensin (Ang) II, other Ang peptides, such as III [Ang-(2–8)], IV [Ang-(3–8)], Ang-(1–7) may also have important biological activities. has become an of interest the past few years, because its cardiovascular baroreflex actions counteract those II. Unique angiotensin-binding sites specific for this heptapeptide studies with selective antagonist indicated existence...
In this study we investigated the effects of genetic deletion angiotensin (Ang)-(1-7) receptor Mas on heart function. Localization in mouse was evaluated by binding rhodamine-labeled Ang-(1-7). Cardiac function examined using isolated preparations. Echocardiography used to confirm results obtained with studies. To elucidate possible mechanisms involved cardiac phenotype observed Mas(-/-) mice, whole-cell calcium currents cardiomyocytes and expression collagen types I, III, VI fibronectin...
It has been described recently that the nonpeptide AVE 0991 (AVE) mimics effects of angiotensin-(1-7) [Ang-(1-7)] in bovine endothelial cells. In this study, we tested possibility is an agonist Ang-(1-7) receptor Mas, vitro and vivo. water-loaded C57BL/6 mice, (0.58 nmol/g body weight) produced a significant reduction urinary volume (0.06+/-0.03 mL/60 min [n=9] versus 0.27+/-0.05 [n=9]; P<0.01), associated with increase osmolality. The antagonist A-779 completely blocked antidiuretic effect...
The antithrombotic effect of angiotensin(Ang)-(1-7) has been reported, but the mechanism this is not known. We investigated participation platelets and receptor Mas-related mechanisms in action. used Western blotting to test for presence Mas protein rat fluorescent-labeled FAM-Ang-(1-7) determine specific binding Ang-(1-7) its displacement by antagonist A-779 Mas−/− Mas+/+ mice platelets. To whether induces NO release from platelets, we indicator DAF-FM. In addition examined role on induced...
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional disease modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2 allele,...
Abstract Objective Heterozygous germline loss-of-function variants in AIP are associated with young-onset growth hormone and/or prolactin-secreting pituitary tumours. However, the pathogenic role of c.911G&gt;A; p.(Arg304Gln) (R304Q) variant has been controversial. Recent data from public exome/genome databases show this is not infrequent. The objective work was to reassess pathogenicity R304Q based on clinical, genomic and functional assay data. Design, materials methods Data were...
Angiotensin-(1–7) [Ang-(1–7)] has biological actions that can often be distinguished from those of angiotensin II (Ang II). Recent studies indicate the effects Ang-(1–7) are mediated by specific receptor(s). We now report partial characterization a new antagonist selective for Ang-(1–7), d -Pro 7 -Ang-(1–7). -Ang-(1–7) (50 pmol) inhibited hypertensive effect induced microinjection [4±1 vs 21±2 mm Hg, 25 pmol alone] into rostral ventrolateral medulla without changing Ang (16±2.5 19±2.5 Hg...
In the present study we investigated effects of physical training on plasma and cardiac angiotensin(1-7) [Ang(1-7)] levels. addition, possible changes in expression Ang(1-7) Mas receptor heart were also evaluated. Normotensive Wistar rats spontaneously hypertensive (SHR) subjected to an 8 week period 5% overload swimming training. Blood pressure was determined by a tail-cuff system. Heart left ventricle weights cardiomyocyte diameter analysed evaluate hypertrophy. Radioimmunoassay used...
The vasodilator/antiproliferative peptide angiotensin-(1-7) [ANG-(1-7)] is released into the corpus cavernosum sinuses, but its role in erectile function has yet to be defined. In this study, we sought determine whether ANG-(1-7) and receptor Mas play a function. was immunolocalized rat by confocal microscopy. Infusion of at rate 15.5 pmol x kg(-1) min(-1) potentiated elevation pressure induced electrical stimulation major pelvic ganglion (MPG) rats. facilitatory effect completely blunted...
Abstract Evidence regarding the components of renin–angiotensin (Ang) system suggests that this plays an important role in male reproduction. However, there are few data available literature on effects Ang‐(1–7) reproductive system. The present study investigated genetic deletion and chronic blockage receptor Mas spermatogenesis fertility. localization mouse rat testes was determined by binding assays immunofluorescence, whereas testis structure spermatogenic process were morphologically...
In the past few years understanding of renin-angiotensin system (RAS) has improved, helping to better define role this in physiological conditions and human diseases. Besides Angiotensin (Ang) II, biological importance other Ang fragments was progressively evidenced. regard, Angiotensin- (Ang-) (1-7) recognized as a biologically active product RAS cascade with specific receptor, G-protein-coupled receptor Mas, that is mainly formed by action angiotensin-converting enzyme (ACE) homolog...
The incidence of ESRD in children has increased over the last two decades. Nevertheless, there are still limited data on risk factors related to emergence among patients with CKD. aim this study was develop a model prediction and adolescents CKD (stages 2-4) enrolled predialysis interdisciplinary management program.In retrospective cohort study, 147 admitted from 1990 2008 were systematically followed up at tertiary pediatric nephrology unit for median about 4.5 years. primary outcome...
The family of angiotensin peptides has been steadily growing in recent years. Most are fragments II (Ang II) with different affinities to the known receptors. Here, we describe a novel endogenous Ang II-like octapeptide plasma from healthy humans and patients end-stage renal failure, which acts as stronger agonist at Mas receptors than 1–7. Chromatographic purification structural analysis by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) revealed an...
PDE4 cyclic nucleotide phosphodiesterases regulate cAMP abundance in cells and therefore numerous processes, including cell growth differentiation. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein (also called XAP2 or ARA-9). Germline mutations occur approximately 20% of patients Familial Isolated Pituitary Adenoma (FIPA) childhood-onset simplex somatotroph adenomas. We examined expression PDE4A4 closely related PDE4A8 normal human pituitary tissue had low but was...