A5080757499- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Global Public Health Policies and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Liver Disease and Transplantation
- Health Systems, Economic Evaluations, Quality of Life
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Acute Myeloid Leukemia Research
- Nutrition, Genetics, and Disease
- Cardiac Health and Mental Health
- Inflammatory Biomarkers in Disease Prognosis
- Health Promotion and Cardiovascular Prevention
- Chronic Kidney Disease and Diabetes
Tehran University of Medical Sciences
2016-2025
Mayo Clinic
2023-2025
WinnMed
2022-2025
Mayo Clinic in Arizona
2023-2025
Mayo Clinic in Florida
2023
University of Tehran
2023
Tehran Heart Center
2020
Universal Scientific Education and Research Network
2017-2019
Shariati Hospital
2016-2018
Endocrinology and Metabolism Population Sciences Institute
2016-2017
Background Rheumatic heart disease (RHD) takes a heavy toll in low- and middle-income countries. We aimed to present worldwide estimates for the burden of RHD during 1990 2019 using GBD (Global Burden Disease) study. Methods Results Sociodemographic index (SDI) age-period-cohort analysis were used assess inequity. The age-standardized death, disability-adjusted life years, incidence, prevalence rates 3.9 (95% uncertainty interval, 3.3-4.3), 132.9 115.0-150.3), 37.4 (28.6-46.7), 513.7...
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional disease modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2 allele,...
Importance Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk atrial fibrillation (AF) through its association with inflammation and cardiac remodeling. Objective To determine whether CHIP was associated AF, inflammatory biomarkers, structural changes. Design, Setting, Participants This a population-based, prospective cohort study in participants Atherosclerosis Risk Communities (ARIC) UK Biobank (UKB) cohort. Samples were collected echocardiography performed...
Abstract Smoking is recognised as a critical public health priority due to its enormous and economic consequences. Constant monitoring of the effectiveness tobacco control programs calls for timely population-based data. This study reports national sub-national patterns in consumption among Iranian adults based on results from STEPwise approach chronic disease risk factor surveillance (STEPS) survey 2021. was performed through an analysis STEPS 2021 which had been conducted nationally...
The MI-GENES clinical trial (NCT01936675), in which participants at intermediate risk of coronary heart disease (CHD) were randomized to receive a Framingham score (FRS
BACKGROUND: In the MI-GENES clinical trial (URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01936675), participants at intermediate risk of coronary heart disease (CHD) were randomized to receive a Framingham score (Framingham group, n=103) or an integrated (integrated group [IRS g ], n=104) that additionally included polygenic score. After 6 months, IRS had higher statin initiation and lower low-density lipoprotein cholesterol. We conducted post hoc 10-year follow-up analysis...
Chylomicronemia is characterized by fasting triglyceride (TG) ≥1000 mg/dL; its longitudinal course not well studied. Using National Health and Nutrition Examination Survey (NHANES) data (1999-2018; n = 21,998), we determined chylomicronemia prevalence temporal trend. Mayo Clinic (4,524,506 TG measurements for 1,294,044 individuals), studied the ascertained persistent (PC), defined as mg/dL in more than half individuals with ≥3 measurements. We used logistic regression to assess factors...
Pragmatic clinical trials (PCTs) evaluate interventions in real-world settings, often using electronic health records (EHRs) for efficient data collection. We report on the challenges performing EHR analysis of health-care provider orders a PCT within eMERGE consortium, which investigates impact reporting genome-informed risk assessments (GIRA) to over 25,000 patients across 10 academic medical centers. Clinical informaticians conducted landscape identify approaches evaluating outcomes GIRA...
Impaired coronary artery reflow after primary percutaneous intervention (PPCI) in patients with ST-segment elevation myocardial infarction has been associated postintervention adverse effects. Thus, finding an easily achievable index would be of great value to predict no-reflow phenomenon. In this regard, platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte (NLR) have introduced. study, we aimed investigate correlation PLR NLR thrombolysis (TIMI) frame count.A total 215...
BACKGROUND In this clinical trial, polyethylene glycol (PEG) solution was compared with lactulose in the treatment of hepatic encephalopathy patients cirrhosis. METHODS This randomized controlled trial performed on 40 two groups. The group received either 20-30 grams orally or by a nasogastric tube, 200 enema rectal tube. PEG-lactulose same amount oral lactulose, plus 280 PEG 4 liters water as single dose 30-120 minutes. Serial physical examinations, scoring algorithm (HESA), blood level...
Background Particulate matter (PM) pollution is a significant risk factor for cardiovascular diseases, causing substantial disease burden and deaths worldwide. This study aimed to investigate the global of diseases attributed PM from 1990 2019. Methods Results We used GBD (Global Burden Disease) 2019 disability-adjusted life-years (DALYs), years life lost (YLLs), lived with disability (YLDs), as well its subgroups. It was shown that all measures' age-standardized rates were in same...
Abstract The study aimed to estimate the prevalence of lipid abnormalities in Iranian adults by demographic characterization, geographical distribution, and associated risk factors using national sub-national representative samples STEPs 2021 survey Iran. In this population-based household survey, a total 18,119 individuals aged over 25 years provided blood for biochemical analysis. Dyslipidemia was defined presence at least one hypertriglyceridemia (≥ 150 mg/dL), hypercholesterolemia 200...
Abstract This study aimed to investigate the diabetes mellitus (DM) and prediabetes epidemiology, care cascade, compliance with global coverage targets. We recruited results of nationally representative Iran STEPS Survey 2021. Diabetes were two main outcomes. awareness, treatment coverage, glycemic control calculated for all population cascade. Four targets developed by World Health Organization adopted assess DM diagnosis status. Among 18,119 participants, national prevalence 14.2% (95%...
Abstract Kidney cancer (KC) is a prevalent worldwide. The incidence and mortality rates of KC have risen in recent decades. quality care provided to patients concern for public health. Considering the importance KC, this study, we aim assess burden disease, gender age disparities globally, regionally, nationally evaluate inequities care. 2019 Global Burden Disease study provides data on KC. secondary indices, including mortality-to-incidence ratio, disability-adjusted life years...
Abstract Severe hypercholesterolemia/possible familial hypercholesterolemia (FH) is relatively common but underdiagnosed and undertreated. We investigated whether implementing clinical decision support (CDS) was associated with lower low-density lipoprotein cholesterol (LDL-C) in patients severe FH (LDL-C ≥ 190 mg/dL). As part of a pre-post implementation study, CDS alert deployed the electronic health record (EHR) large system comprising 3 main sites, 16 hospitals 53 clinics. Data were...
The joint effects of polygenic risk and social determinants health (SDOH) on coronary heart disease (CHD) in the United States are unknown. In 67,256 All Us (AoU) participants with available SDOH data, we ascertained self-reported race/ethnicity calculated a score for CHD (PRS ). We used 90 survey questions to develop an (SDOH assessed distribution across races US states. tested association PRS regression models that included clinical factors. was highest black Hispanic people....