Russell J. Crew
A5078400139- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Complement system in diseases
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Chronic Kidney Disease and Diabetes
- Cytomegalovirus and herpesvirus research
- Acute Kidney Injury Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parvovirus B19 Infection Studies
- Polyomavirus and related diseases
- Blood disorders and treatments
- Pregnancy and Medication Impact
- Electrolyte and hormonal disorders
- Renal and related cancers
- Peripheral Artery Disease Management
- Organ and Tissue Transplantation Research
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Autoimmune Bullous Skin Diseases
- Potassium and Related Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric Urology and Nephrology Studies
Columbia University
2012-2025
Columbia University Irving Medical Center
2009-2024
NewYork–Presbyterian Hospital
2014-2020
Royal College of Physicians
2019
Columbia College
2019
Presbyterian Hospital
2004-2010
National Institute of Diabetes and Digestive and Kidney Diseases
2007
National Institutes of Health
2007
Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders adults, including chronic kidney disease, which affects more than 1 10 persons globally.
Minimal-change disease (MCD) counts for 10 to 15% of cases primary nephrotic syndrome in adults. Few series have examined this A retrospective review was performed 95 adults who had MCD and were seen at a single referral center. Examined presenting features, response daily versus alternate-day steroids, second-line agents, relapse patterns, complications the therapy, presence acute renal failure (ARF), outcome data. Sixty-five patients received 23 steroids initially. There no differences...
Half of the recovered expanded criteria donor (ECD) kidneys are discarded in United States. A new kidney allocation system offers at higher risk discard, Kidney Donor Profile Index (KDPI)>85%, to a wider geographic area promote broader sharing and expedite utilization. Dual transplantation (DKT) based on KDPI is potential option streamline which otherwise would have been discarded. To assess clinical utility we analyzed OPTN/UNOS Registry that included deceased between 2002 2012. The primary...
Background and objectives Outcomes of kidney transplant recipients diagnosed with coronavirus disease 2019 as outpatients have not been described. Design, setting, participants, & measurements We obtained clinical data for 41 consecutive outpatient known or suspected 2019. Chi-squared Wilcoxon rank sum tests were used to compare characteristics patients who required hospitalization versus those did not. Results Of patients, 22 (54%) had confirmed 2019, 19 (46%) cases. Patients most...
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional disease modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2 allele,...
Background and Purpose— Inflammatory biomarkers predict incident recurrent cardiac events, but their relationship to stroke prognosis is uncertain. We hypothesized that high-sensitivity C-reactive protein (hsCRP) predicts ischemic after recent lacunar stroke. Methods— Levels of Markers in the Treatment Stroke (LIMITS) was an international, multicenter, prospective ancillary biomarker study nested within Secondary Prevention Small Subcortical Strokes (SPS3), a phase III trial patients with...
Biopsy findings at the time of procurement deceased donor kidneys remain most common reason cited for kidney discard. To determine value renal allograft histology in predicting outcomes, we evaluated significance histologic findings, read by experienced pathologists, 975 postreperfusion biopsy specimens collected from 2005 to 2009 after living ( n =427) or =548) transplant. We degree glomerulosclerosis, interstitial fibrosis and tubular atrophy, vascular disease; with a score 0 1 (scale,...
Background and objectives Actionable genetic findings have implications for care of patients with kidney disease, testing is an emerging tool in nephrology practice. However, there are scarce data regarding best practices return results clinical application actionable patients. Design, setting, participants, & measurements We developed a workflow collaborations clinicians the retrospective recontact adult who had been recruited into biobank research study exome sequencing were identified...
Abstract BACKGROUND A significant number of kidney transplant recipients have low BMD. We hypothesized that calcitriol administration over the first year post-transplantation would protect cortical skeleton in managed without corticosteroids by suppressing PTH and bone remodeling. METHODS In this double-blind, placebo-controlled trial, 67 participants aged ≥18 years on corticosteroid-sparing immunosuppressive regimen were randomized to daily 0.5 mcg or placebo for 12 months after...
The number of kidneys obtained from deceased diabetic donors available for transplantation has increased >eightfold increase in the past 15 years. We assessed allograft outcomes associated with and compared them that standard extended criteria (ECD) UNOS data registry. identified 1982 recipients over a 10-year period 1995 through 2004. Both overall death-censored survival organs was significantly better than nondiabetic ECD while inferior to donors. Compared donors, had lower serum...
<h3>Objectives:</h3> To determine whether vascular and demographic factors predict worsening disability up to 8 years after lacunar stroke. <h3>Methods:</h3> SPS3 (Secondary Prevention of Small Subcortical Strokes) was a clinical trial in stroke patients with annual assessment using the Older Americans Resources Survey instrumental activities daily living (IADL) scale (range 0–14). Generalized estimating equations modeled likelihood (IADL <14) over time, adjusting for demographics,...
C3 glomerulopathy (C3G), which encompasses C3GN and dense deposit disease (DDD), results from dysregulation of the alternative complement pathway. Data on recurrence after kidney transplantation are limited, details histologic features recurrent C3G scarce. We aimed to evaluate in allograft, with a focus presentation progression.
The term thrombotic microangiopathy (TMA) hasbeenapplied toa diversegroup of conditionsthat sharethe common pathomechanism endothelial damage.TMA is a recognized complication solid organtransplantation.ThemajorityofcasesrepresentdenovoTMA, which occurs in 02.8–3.5% renal transplantrecipients and associated with 22% rate graftloss [1]. graft loss strongly influencedby whether the TMA systemic or limited (38vs 0% loss, respectively) [1].Treatment calcineurin inhibitors (CNIs) awell-established...
The factors that influence deceased donor kidney procurement biopsy reliability are not well established. We examined the impact of technique and pathologist training on accuracy.We retrospectively identified all kidney-only transplants at our center from 2006 to 2016 with both reperfusion biopsies performed information available (n = 392). Biopsies were scored using a previously validated system, classifying "suboptimal" histology as presence least 1 following: glomerulosclerosis ≥11%,...
Background Allograft outcomes in patients undergoing repeat renal transplantation are inferior compared to first-time transplant recipient outcomes. Donor-specific antibodies detected by solid-phase assays (DSA-SPA) may contribute the worse prognosis. The influence of DSA-SPA on has not been previously studied detail. Design This study reports findings 174 who underwent between years 2007 and 2012. These included 62 with preformed Luminex at time transplantation. Patients received standard...
ABO-incompatible (ABOi) and positive crossmatch (XM) renal transplants pose special immunologic challenges. It is important to compare outcomes, study resource utilization, attempt risk stratify patients in these higher transplant settings.We compared apheresis utilization outcomes ABOi, XM, combined ABOi-XM transplants. We also analyzed multiple parameters, including patient laboratory variables, identify predictors of outcome.Incidences early (< or =30 days posttransplant)...