A5045389762- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Renal and Vascular Pathologies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pregnancy and Medication Impact
- Complement system in diseases
- Polyomavirus and related diseases
- Metabolism and Genetic Disorders
- Long-Term Effects of COVID-19
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Transplantation: Methods and Outcomes
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Hospital Admissions and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neutropenia and Cancer Infections
- COVID-19 Impact on Reproduction
- Healthcare Policy and Management
- Bone and Joint Diseases
Columbia University
2014-2025
Columbia University Irving Medical Center
2015-2024
University of KwaZulu-Natal
2022
NewYork–Presbyterian Hospital
2002-2020
Columbia College
2019
Royal College of Physicians
2019
New York Hospital Queens
2002-2017
Icahn School of Medicine at Mount Sinai
1998
NKP Salve Institute of Medical Sciences and Lata Mangeshkar Hospital
1998
Solid organ transplant recipients may be at a high risk for SARS-CoV-2 infection and poor associated outcomes. We herein report our initial experience with solid two centers during the first 3 weeks of outbreak in New York City. Baseline characteristics, clinical presentation, antiviral immunosuppressive management were compared between patients mild/moderate severe disease (defined as ICU admission, intubation or death). Ninety analyzed median age 57 years. Forty-six kidney recipients, 17...
Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders adults, including chronic kidney disease, which affects more than 1 10 persons globally.
Corticosteroid use after kidney transplantation results in severe bone loss and high fracture risk. Although corticosteroid withdrawal the early posttransplant period has been associated with mass preservation, there are no published data regarding risk of fracture. We hypothesized lower incidence patients discharged from hospital without than corticosteroids transplantation. From United States Renal Data System (USRDS), 77, 430 were identified who received their first transplant 2000 to...
Half of the recovered expanded criteria donor (ECD) kidneys are discarded in United States. A new kidney allocation system offers at higher risk discard, Kidney Donor Profile Index (KDPI)>85%, to a wider geographic area promote broader sharing and expedite utilization. Dual transplantation (DKT) based on KDPI is potential option streamline which otherwise would have been discarded. To assess clinical utility we analyzed OPTN/UNOS Registry that included deceased between 2002 2012. The primary...
Background and objectives Outcomes of kidney transplant recipients diagnosed with coronavirus disease 2019 as outpatients have not been described. Design, setting, participants, & measurements We obtained clinical data for 41 consecutive outpatient known or suspected 2019. Chi-squared Wilcoxon rank sum tests were used to compare characteristics patients who required hospitalization versus those did not. Results Of patients, 22 (54%) had confirmed 2019, 19 (46%) cases. Patients most...
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional disease modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2 allele,...
Little is known about the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria following kidney transplantation. We determined incidence post-transplant CRKP in adults who underwent transplant from 2007 to 2010 at 2 New York City centers.We conducted a case-control study identify factors associated with compared carbapenem-susceptible K. (CSKP) bacteriuria, assessed whether was mortality or graft failure, and outcomes treated episodes CSKP bacteriuria.Of 1852...
Biopsies taken at deceased donor kidney procurement continue to be cited as a leading reason for discard; however, the reproducibility and prognostic capability of these biopsies are controversial.We compiled retrospective, single-institution, continuous cohort transplants performed from 2006 2009. Procurement biopsy information-percentage glomerulosclerosis, interstitial fibrosis/tubular atrophy, vascular disease-was obtained national transplant database. Using univariable, multivariable,...
Introduction A large proportion of patients with COVID-19 develop acute kidney injury (AKI). While the most severe these cases require renal replacement therapy (RRT), little is known about their clinical course. Methods We describe characteristics in ICU AKI requiring RRT at an academic medical center New York City and followed for outcomes death recovery using time-to-event analyses. Results Our cohort 115 represented 23% all admissions our center, a peak prevalence 29%. Patients were...
Coronavirus infectious disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has significant global morbidity and mortality since first emerging as a pathogen at the end of 2019. Acute kidney injury, most commonly due to tubular is frequent finding in COVID-19, occurring 17% 37% patients.1–3 De novo glomerular much less common with although cases new-onset collapsing glomerulopathy, immune-complex glomerulonephritis, antineutrophil cytoplasmic...
Solid organ transplant recipients are at an elevated risk of severe coronavirus disease 2019 (COVID-19), and early reports also suggest impaired response after the first dose a acute respiratory syndrome 2 (SARS-CoV-2) mRNA vaccine series.1Kates O.S. Haydel B.M. Florman S.S. et al.COVID-19 in solid transplant: multi-center cohort study [e-pub ahead print]. Clin Infect Dis.https://doi.org/10.1093/cid/ciaa1097Date accessed: May 5, 2021Google Scholar, 2Boyarsky B.J. Werbel W.A. Avery R.K....
Abstract BACKGROUND A significant number of kidney transplant recipients have low BMD. We hypothesized that calcitriol administration over the first year post-transplantation would protect cortical skeleton in managed without corticosteroids by suppressing PTH and bone remodeling. METHODS In this double-blind, placebo-controlled trial, 67 participants aged ≥18 years on corticosteroid-sparing immunosuppressive regimen were randomized to daily 0.5 mcg or placebo for 12 months after...
We report the clinical and pathologic findings in 7 patients with systemic lupus erythematosus minimal change disease. All presented full nephrotic syndrome including peripheral edema, range proteinuria (mean 9.6 g/day), hypoalbuminemia 1.8 g/dl). In all cases, renal biopsy revealed diffuse foot process effacement absence of significant capillary wall immune deposits, consistent minimal-change addition, 5 cases displayed mesangial electron-dense or without associated proliferation,...
Biopsy findings at the time of procurement deceased donor kidneys remain most common reason cited for kidney discard. To determine value renal allograft histology in predicting outcomes, we evaluated significance histologic findings, read by experienced pathologists, 975 postreperfusion biopsy specimens collected from 2005 to 2009 after living ( n =427) or =548) transplant. We degree glomerulosclerosis, interstitial fibrosis and tubular atrophy, vascular disease; with a score 0 1 (scale,...
Background and objectives Actionable genetic findings have implications for care of patients with kidney disease, testing is an emerging tool in nephrology practice. However, there are scarce data regarding best practices return results clinical application actionable patients. Design, setting, participants, & measurements We developed a workflow collaborations clinicians the retrospective recontact adult who had been recruited into biobank research study exome sequencing were identified...
Background and objectives Unfavorable histology on procurement biopsies is the most common reason for deceased donor kidney discard. We sought to assess reproducibility of biopsy findings. Design, setting, participants, & measurements compiled a continuous cohort kidneys transplanted at our institution from 1/1/2006 12/31/2016 that had least one performed, excluded cases with missing reports those used in multiorgan transplants. Suboptimal was defined as presence advanced sclerosis...
The number of kidneys obtained from deceased diabetic donors available for transplantation has increased >eightfold increase in the past 15 years. We assessed allograft outcomes associated with and compared them that standard extended criteria (ECD) UNOS data registry. identified 1982 recipients over a 10-year period 1995 through 2004. Both overall death-censored survival organs was significantly better than nondiabetic ECD while inferior to donors. Compared donors, had lower serum...
There are limited data on the nonprocurement of kidneys from solid organ donors. Analysis Standard Transplant and Research files was undertaken all deceased donors in United States with at least 1 recovered. From 2000 to 2018, 21 731 donor (averaging 1144 per year) were not procured. No procured 8% liver donors, 3% heart lung Compared procured, those none older more likely obese, black, hypertensive, diabetic, hepatitis C positive, smokers, Public Health Service – Increased Risk designated,...