A5043694137- Intestinal and Peritoneal Adhesions
- Surgical Sutures and Adhesives
- Hernia repair and management
- COVID-19 Clinical Research Studies
- Hemostasis and retained surgical items
- Minimally Invasive Surgical Techniques
- Thyroid and Parathyroid Surgery
- Uterine Myomas and Treatments
- Orthopedic Surgery and Rehabilitation
- Electrospun Nanofibers in Biomedical Applications
- Tendon Structure and Treatment
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Angiogenesis and VEGF in Cancer
- Reconstructive Surgery and Microvascular Techniques
- SARS-CoV-2 and COVID-19 Research
- Music Therapy and Health
- Coal Properties and Utilization
- Endometriosis Research and Treatment
- COVID-19 and healthcare impacts
- Anesthesia and Pain Management
- Coal and Coke Industries Research
- Parasitic Diseases Research and Treatment
- Corneal Surgery and Treatments
- Neural dynamics and brain function
Chelsea and Westminster Hospital NHS Foundation Trust
2024
Synertech PM (United States)
2003-2023
ORCID
2023
Digital Research Alliance of Canada
2021
Uppsala University
2002
Johnson & Johnson (United States)
1990-1999
University Medical Center
1992
Yale University
1992
The Orthopaedic Institute
1990
New York University Langone Orthopedic Hospital
1990
Abstract Background: The development of conveniently sprayed, tissue-adherent, inert hydrogel films has made possible the creation novel products that can serve a dual function, as surgical sealant to achieve immediate hemostasis, and barrier prevent adhesion formation over time. Methods: A sprayable, in situ formed absorbable film was evaluated tissue heparinized canine carotid artery graft model. PTFE grafts with leaking end-to-side anastomoses were treated synthetic sealant, hemostasis...
Background: In vitro transcription (IVT) reactions used to generate nucleoside modified RNA (modRNA) for SARS-CoV-2 vaccines currently rely on an polymerase transcribing from a DNA template. Production of modRNA in the original Pfizer randomized clinical trial (RCT) utilized PCR-generated template (Process 1). To billions vaccine doses, this was cloned into bacterial plasmid vector amplification Escherichia coli before linearization 2), expanding size and complexity potential residual...
Adhesion formation after bowel surgery is a significant problem. The objective of this study was to evaluate two adhesion barriers composed oxidized regenerated cellulose (ORC) in model surgery, with and without bleeding. Ceca female New Zealand White rabbits were abraded gauze 3x5 cm patch peritoneum underlying muscle excised from the right sidewall. Animals randomized receive no treatment, INTERCEED Barrier (Ethicon, Inc.), or neutralized (nTC7). ORC fabrics applied excision site. Seven...
<h3>Objectives:</h3> To determine whether vascular and demographic factors predict worsening disability up to 8 years after lacunar stroke. <h3>Methods:</h3> SPS3 (Secondary Prevention of Small Subcortical Strokes) was a clinical trial in stroke patients with annual assessment using the Older Americans Resources Survey instrumental activities daily living (IADL) scale (range 0–14). Generalized estimating equations modeled likelihood (IADL <14) over time, adjusting for demographics,...
Adhesion formation associated with tendon surgery is a widespread problem in which healing becomes adherent via scar tissue to surrounding structures such as bone, muscle, skin, sheath, or other tendons. A model described adhesions were generated reproducibly between the plantaris and Achilles tendons of rabbit using partial tenotomy, Bunnel suture, immobilization. Using this model, effect an absorbable barrier, INTERCEED (TC7), on adhesion was investigated. This material, fabric comprised...
We comment on the study by Mulroney et al.(1) entitled: “N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting.” The found evidence in mice and humans for misreading modRNA contained within Pfizer COVID-19 vaccine to inadvertently produce “off-target” proteins capable eliciting immune responses. authors propose that these novel are result frameshifting occasioned substitution N1-methyl pseudouridine. state “error prone” code is a safety concern with “huge potential be harmful”...
Tolmetin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces adhesion formation in several animal models after single intraperitoneal (i.p.) dose delivered at the time of surgery. We set out to determine period during which tolmetin could prevent adhesions. Adhesions were induced New Zealand White rabbits (2-3 kg) by abrading uterine horns and removing their mesouterine vasculature. sodium (1 mg/5 ml saline) was given various times relative start surgery as i.p. One week later...