A5008563300- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Dental Education, Practice, Research
- Chemokine receptors and signaling
- Proteoglycans and glycosaminoglycans research
- interferon and immune responses
- Dental Research and COVID-19
- Wound Healing and Treatments
- Protease and Inhibitor Mechanisms
- Dental Health and Care Utilization
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Corneal Surgery and Treatments
- Retinoids in leukemia and cellular processes
- Health and Medical Research Impacts
- Viral-associated cancers and disorders
- Immune cells in cancer
- Oral and Maxillofacial Pathology
- Mesenchymal stem cell research
- RNA modifications and cancer
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
University of Michigan
2013-2024
Michigan Medicine
2018
American Association for Dental Research
2013-2015
International Association for Dental Research
2013-2015
Medical University of South Carolina
2014
Michigan United
2014
Texas A&M Health Science Center
2013
University of Minnesota
2002-2004
Northwestern University
1986-2003
Loyola University Medical Center
1996-2003
Angiogenic factors produced by monocytes-macrophages are involved in the pathogenesis of chronic inflammatory disorders characterized persistent angiogenesis. The possibility was tested that interleukin-8 (IL-8), which is a cytokine chemotactic for lymphocytes and neutrophils, also angiogenic. Human recombinant IL-8 potently angiogenic when implanted rat cornea induced proliferation chemotaxis human umbilical vein endothelial cells. activity present conditioned media inflamed rheumatoid...
Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) expressed primarily in the hypothalamus. Here, it shown OB-Rb also human vasculature primary cultures of endothelial cells. In vitro vivo assays revealed leptin has angiogenic activity. vivo, induced neovascularization corneas from normal rats but not fa/fa Zucker rats, which lack functional receptors. These observations indicate vascular endothelium target for suggest physiological mechanism whereby leptin-induced...
In this study, we demonstrate that the CXC family of chemokines displays disparate angiogenic activity depending upon presence or absence ELR motif. containing motif (ELR-CXC chemokines) were found to be potent factors, inducing both <i>in vitro</i> endothelial chemotaxis and vivo</i> corneal neovascularization. contrast, lacking motif, platelet factor 4, interferon γ-inducible protein 10, monokine induced by γ-interferon, not only failed induce significant cell neovacularization but...
A secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in hamster cells has been found to be similar fragment the platelet and matrix protein thrombospondin. The two proteins were biochemically immunologically crossreactive could substitute for one another functional assays. Human thrombospondin inhibited neovascularization vivo endothelial cell migration vitro, as does protein, gp140. gp140 sensitized smooth muscle stimulation epidermal growth factor, human...
Scatter factor (also known as hepatocyte growth factor) is a glycoprotein secreted by stromal cells that stimulates cell motility and proliferation. In vitro, scatter vascular endothelial migration, proliferation, organization into capillary-like tubes. Using two different in vivo assays, we showed physiologic quantities of purified native mouse recombinant human induce angiogenesis (the formation new blood vessels). The angiogenic activity was blocked specific anti-scatter antibodies....
The salient feature of solid tumor growth is the strict dependence on local angiogenesis. We have previously demonstrated that IL-8 an angiogenic factor present in freshly isolated specimens human non-small cell lung cancer (NSCLC). Using a model NSCLC tumorigenesis SCID mice, we now report acts as promoter through its properties. Passive immunization with neutralizing antibodies to resulted more than 40% reduction size and was associated decline tumor-associated vascular density activity....
We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis human bronchogenic carcinoma. Increased quantities IL-8 were detected tumor tissue as compared with normal lung tissue. Immunohistochemical staining tumors revealed primary localization to individual cells and demonstrated capacity elaborate IL-8. Functional studies that used homogenates induction both vitro endothelial cell chemotaxis vivo corneal neovascularization. It is important note addition neutralizing...
B61, a cytokine-inducible endothelial gene product, is the ligand for Eck receptor protein tyrosine kinase (RPTK). Expression of B61-immunoglobulin chimera showed that B61 could act as an angiogenic factor in vivo and chemoattractant cells vitro. The RPTK was activated by tumor necrosis factor-α (TNF-α) through induction antibody to attenuated angiogenesis induced TNF-α but not basic fibroblast growth factor. This finding suggests existence autocrine or paracrine loop involving activation...
The success of solid tumor growth and metastasis is dependent upon angiogenesis. Neovascularization within the regulated, in part, by a dual opposing system angiogenic angiostatic factors. We now report that IP-10, recently described factor, as potent factor regulates non-small cell lung cancer (NSCLC)-derived angiogenesis, growth, spontaneous metastasis. initially found significantly elevated levels IP-10 freshly isolated human NSCLC samples squamous carcinoma (SCCA). In contrast, were...
Captopril, an inhibitor of angiotensin converting enzyme, is widely used clinically to manage hypertension and congestive heart failure. Here captopril shown be angiogenesis able block neovascularization induced in the rat cornea. Captopril acted directly specifically on capillary endothelial cells, inhibiting their chemotaxis with a biphasic dose-response curve showing initial decrease at achievable doses under 10 microM further slow decline millimolar range. inhibition cell migration was...
Matrix proteases play a critical role in cell invasion and migration, including the process of angiogenesis. The ability specific factors to induce angiogenic responses correlates with their stimulation matrix protease synthesis release. Using an vivo angiogenesis assay, endothelial response known factors, basic fibroblast growth factor (bFGF) adipocyte conditioned medium, was blocked by inhibitor metalloproteinase activity, TIMP-1. TIMP effect mediated, at least part, through inhibition as...