A5025824132- Nausea and vomiting management
- Anesthesia and Pain Management
- Glioma Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Ocular Oncology and Treatments
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Neurofibromatosis and Schwannoma Cases
- Genetic factors in colorectal cancer
- Non-Invasive Vital Sign Monitoring
- Esophageal Cancer Research and Treatment
- Regulation of Appetite and Obesity
- Cutaneous lymphoproliferative disorders research
- Respiratory Support and Mechanisms
- melanin and skin pigmentation
- Chromatin Remodeling and Cancer
- Viral-associated cancers and disorders
- Pain Management and Opioid Use
- Abdominal Trauma and Injuries
- Cancer Mechanisms and Therapy
- Abdominal Surgery and Complications
Saitama Medical University
2021-2025
Social Insurance Saitama Chuo Hospital
2021-2025
Saitama Cancer Center
2024
Tokushima University
2017-2022
Gunma University
2018-2020
Tokushima Prefectural Central Hospital
2018
Institute of Biomedical Science
2018
Bayer (United States)
1998
University of Michigan
1998
Yale University
1998
Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) expressed primarily in the hypothalamus. Here, it shown OB-Rb also human vasculature primary cultures of endothelial cells. In vitro vivo assays revealed leptin has angiogenic activity. vivo, induced neovascularization corneas from normal rats but not fa/fa Zucker rats, which lack functional receptors. These observations indicate vascular endothelium target for suggest physiological mechanism whereby leptin-induced...
With the advent of immune checkpoint inhibitors (ICIs), a better understanding tumor microenvironment (TME) is becoming crucial in managing esophageal squamous cell carcinoma (ESCC) patients. We investigated survival impact TME status and changes patients with ESCC who underwent neoadjuvant chemotherapy (NAC) followed by surgery (n = 264). examined immunohistochemical (CD4
ABSTRACT Urinary bladder cancer includes non‐muscle invasive (NMIBC) and muscle (MIBC). While patients with NMIBC have a better prognosis, often recurs, requiring long‐term surveillance repeated treatments. Intravesical Bacillus Calmette‐Guérin (BCG) therapy is standard for high‐grade or recurrent NMIBC; however, 30%–50% of failed to respond, the mechanisms resistance remain unclear. To identify predictive biomarkers response intravesical BCG therapy, we analyzed NANOG Histone deacetylase 1...
Postoperative nausea and vomiting (PONV) occur in 30–50% of patients undergoing general anesthesia 70–80% high PONV risk patients. In this study, we investigated the efficacy fosaprepitant, a neurokinin-1 (NK1) receptor antagonist, compared to ondansetron, selective 5-hydroxytryptamine type 3 (5-HT3) moderate from our previous randomized controlled trials. Patients (171 4 pooled studies) with Apfel simplified score ≥ 2 were randomly allocated receive intravenous fosaprepitant 150 mg (NK1...
Robot-assisted laparoscopic radical prostatectomy (RALRP) is commonly performed in the surgical treatment of prostate cancer. However, steep Trendelenburg position (25) and pneumoperitoneum required for this procedure can sometimes cause hemodynamic changes. Although blood pressure traditionally monitored invasively during RALRP, ClearSight system (BMEYE, Amsterdam, The Netherlands) enables a totally noninvasive simple continuous cardiac output monitoring based on finger arterial pulse...
Náusea e Vômito no Pós‐Operatório (NVPO) é um evento adverso frequente da anestesia geral. Várias classes de antieméticos, incluindo antagonistas do receptor 5‐Hidroxitriptamina3 (5‐HT3) Neurocinina‐1 (NK‐1), têm sido utilizados para tratar a NVPO. Comparar o efeito antiemético dos NK‐1, fosaprepitanto. Foram utilizadas bases dados on‐line (PubMed, MEDLINE, Scopus, The Cochrane Library). incluídos Estudos Clínicos Randomizados (ECR) realizados em pacientes acima 18 anos classificação ASA I...
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare condition characterized by benign localized lymphadenopathy and clinical symptoms such fever, sore throat, odynophagia, leukopenia. Though the etiology of KFD unknown, this similar to viral infection, including increased infiltration activated plasmacytoid dendritic cells. exhibits three histological phases that reflect its progression status: proliferative, necrotic, xanthomatous lesions. The...
Background . It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides anesthesia in labor. This randomized double-blind trial compared postoperative analgesic efficacy of PIEB with continuous infusion (CEI) patients undergoing gynecological surgery under combined general-epidural anesthesia. Methods Patients open were at a 1 : ratio to receive or CEI. In group, pump delivered 4 mL ropivacaine 0.2% plus fentanyl 2 μ g/mL every hour. CEI same...
Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant of the central nervous system that predominantly occur in infants, and characterized by presence rhabdoid cells inactivation INI1 or (rarely) BRG1. Most AT/RT identified as primary tumors; however, rare INI1-deficient RTs arising from other have been reported. Here, we report 3 cases hitherto unclassifiable low-grade with loss nuclear expression, for which propose designation diffusely infiltrative deficiency (CNS LGDIT-INI1), 2...
We investigated the effectiveness of ClearSight system for hemodynamic management during kidney transplantation a recipient. The recipient was to receive transplant from his mother under general anesthesia. used continuous noninvasive finger‐cuff‐based monitoring blood pressure, provided by system, and stroke volume variation predict fluid responsiveness. balanced anesthetic technique stringent standards ensure successful outcome patient. This case demonstrated that has potential improve...
A 40‐year‐old man was admitted to our hospital because of disorientation and mild left‐sided weakness. Radiological examination revealed a solid cystic tumor in the right temporal lobe, total resection performed. Histologically, composed mainly low‐grade gangiloglioma had some high‐grade glial components with focal necrosis microvascular proliferations. In component, there were epithelioid cells round cytoplasm eccentric nuclei. The area intermingled within area, which suggests that an...
Two types of amniotic fluid embolism (AFE) have been described : cardiopulmonary collapse type and disseminated intravascular coagulation (DIC) type, with the latter proposed as uterine type. This report describes a healthy 28-year-old woman who developed AFE during cesarean section. Because previous section, patient underwent an elective under combined spinal-epidural anesthesia, at 38 weeks pregnancy. She began coughing 5 minutes after delivery fetus, subsequently becoming unconscious...
Study Objective : the incidence of postoperative nausea and vomiting (PONV) following single-injection intraarticular anesthesia was compared to that continuous epidural anesthesia. Design Prospective, double-blind, randomized study. Setting University-affiliated teaching hospital. Patients Forty-eight patients finally participated in this study, each group contained twenty-four patients. Interventions scheduled undergo lower limb surgery under general were randomly allocated into two...
We report a histological and genetic study of concurrent oligodendroglioma microscopic pleomorphic xanthoastrocytoma (PXA)-like lesion in 48-year-old male. He presented with generalized seizure, magnetic resonance imaging revealed nonenhanced left frontal lobe mass suggesting low-grade glioma. The patient underwent craniotomy tumor resection. Histopathological examination the surgical specimen showed an PXA-like element; latter measured 0.9 mm occupied Virchow-Robin space superficial cortex....
Most pituitary adenoma/neuroendocrine tumours (PitNET) are histologically benign and grow slowly; however, a subset of these exhibit more aggressive clinical course characterized by local invasiveness early recurrence. These high-risk PitNETs often require multiple surgeries radiation over several years may eventually acquire carcinomatous characteristics, such as metastasis in some cases. Herein, we report rare case PitNET causing oculomotor paresis with extremely rapid recurrence only 3...
We compared the two methods of assessing CD30 protein expression in DLBCL and TCL specimens routinely employed at our hospital, immunohistochemistry (IHC) flow cytometry (FCM), using same clone anti-CD30 antibody (Ber-H2) 123 patients with 28 TCL. FCM was more sensitive than IHC, especially cases low expression. In three DLBCL, there discordance between these methods. Two were ALCL one peripheral T-cell lymphoma, NOS, but unable to be excluded. One an anaplastic variant DLBCL. The data...
In the World Health Organization Classification of Brain Tumors Fifth Edition, mesenchymal non-meningothelial tumors involving central nervous system are divided into three major categories: soft tissue tumors, chondro-osseous and notochordal tumors. Soft classified four groups: fibroblastic myofibroblastic vascular skeletal muscle uncertain differentiation. This article will focus on solitary fibrous tumors(SFTs), which frequently encountered clinically continue to undergo classification...