Abstract Background Remimazolam confers a lower risk of hypotension than propofol. However, no studies have compared the efficacy remimazolam and propofol administered using target-controlled infusion (TCI). This study aimed to investigate hemodynamic effects in middle-aged elderly patients during induction anesthesia. Methods Forty adults aged 45–80 years with American Society Anesthesiologists Physical Status 1–2 were randomly assigned or group ( n = 20 each). Patients received either (12...

Purpose: Post-operative nausea and vomiting (PONV) remains the most frequently reported patient complaint after anesthesia. Aprepitant is first neurokinin-1(NK1) receptor antagonism available for use as an antiemetic. We investigated whether aprepitant can effectively decrease PONV in patients undergoing laparoscopic gynecological surgery. Methods: Sixty four receiving general anesthesia surgery were randomly assigned to either receive a preoperative dose of 80 mg or no drug. Efficacy was...

AsisTIVA is total intravenous anesthesia support software for syringe pump control. It remains the only automated program to have achieved both practical and commercial viability. has been certified use at Tokushima University, Tohoku its developer institution, Fukui University. We conducted our initial management with This experience was successful, no adverse effects. controls propofol remifentanil concentrations maintain a Bispectral index of 45 adjusts rocuronium Train Of Four value 1....

(1) Background: Remimazolam is a novel benzodiazepine that prevents postoperative nausea and vomiting (PONV), more effective than volatile anesthetics, was recently approved for use in Japan. (2) Methods: This prospective, double-blind, randomized controlled trial study aimed to compare the efficacy of remimazolam propofol as general anesthetics terms incidence PONV after laparoscopic gynecological surgery (UMIN000046237). High-risk female patients who underwent anesthesia with either or...

The incidence of postoperative nausea and vomiting (PONV) is 30–50% after surgery. PONV occurs frequently, especially craniotomy. In this study, we investigated the preventive effects on in a randomized study by comparing patients who had been administered fosaprepitant, neurokinin-1 (NK1) receptor antagonist, or ondansetron intravenously. Sixty-four undergoing craniotomy were randomly allocated to receive fosaprepitant 150 mg i.v. (NK1 group, n = 32) 4 (ONS before anesthesia. was...

Enhanced recovery after surgery is increasingly desired nowadays, and preoperative nutrient intake may be beneficial for this purpose. In study, we investigated whether the of carbohydrate with amino acid (ONS) solution can improve starvation status lipid catabolism before induction anesthesia. This randomized, prospective clinical trial included 24 patients who were divided into two groups under general anesthesia: a control group, comprising fasted their last meal day (permitted to drink...

Abstract Background This study evaluated whether desflurane improved lung collapse during one-lung ventilation (OLV) more than propofol, and it could reduce the operation time of video-assisted thoracic surgery. Methods Sixty patients undergoing lobectomy by surgery (VATS) were randomly assigned to general anesthesia with or propofol. Lungs inspected thoracoscope at 10, 30, 60 min after initiation OLV. After surgery, Lung Collapse Score, a composite color volume assessments, was two...

Background During perioperative fasting, lipid metabolism gradually increases, resulting in free fatty acids (FFA) and/or ketone bodies. Suppression of surgical stress by remifentanil may allow the safe administration glucose infusions, avoiding both hyperglycemia and ketogenesis. The effects infusion on were therefore investigated patients undergoing minor surgery with anesthesia. Methods Thirty-four randomized 1 : to receive no (0G group) or low-dose (0.1 g/kg/h for h followed 0.05 h; LG...

Postoperative nausea and vomiting (PONV) occur in 30–50% of patients undergoing general anesthesia 70–80% high PONV risk patients. In this study, we investigated the efficacy fosaprepitant, a neurokinin-1 (NK1) receptor antagonist, compared to ondansetron, selective 5-hydroxytryptamine type 3 (5-HT3) moderate from our previous randomized controlled trials. Patients (171 4 pooled studies) with Apfel simplified score ≥ 2 were randomly allocated receive intravenous fosaprepitant 150 mg (NK1...

Robot-assisted laparoscopic radical prostatectomy (RALRP) is commonly performed in the surgical treatment of prostate cancer. However, steep Trendelenburg position (25) and pneumoperitoneum required for this procedure can sometimes cause hemodynamic changes. Although blood pressure traditionally monitored invasively during RALRP, ClearSight system (BMEYE, Amsterdam, The Netherlands) enables a totally noninvasive simple continuous cardiac output monitoring based on finger arterial pulse...

Náusea e Vômito no Pós‐Operatório (NVPO) é um evento adverso frequente da anestesia geral. Várias classes de antieméticos, incluindo antagonistas do receptor 5‐Hidroxitriptamina3 (5‐HT3) Neurocinina‐1 (NK‐1), têm sido utilizados para tratar a NVPO. Comparar o efeito antiemético dos NK‐1, fosaprepitanto. Foram utilizadas bases dados on‐line (PubMed, MEDLINE, Scopus, The Cochrane Library). incluídos Estudos Clínicos Randomizados (ECR) realizados em pacientes acima 18 anos classificação ASA I...

Background . It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides anesthesia in labor. This randomized double-blind trial compared postoperative analgesic efficacy of PIEB with continuous infusion (CEI) patients undergoing gynecological surgery under combined general-epidural anesthesia. Methods Patients open were at a 1 : ratio to receive or CEI. In group, pump delivered 4 mL ropivacaine 0.2% plus fentanyl 2 μ g/mL every hour. CEI same...

Purpose : We evaluated the effect of 10-min prewarming on core temperature maintenance during general anesthesia. Patients randomized 40 women scheduled for breast cancer surgery into Prewarming and Control groups. In group, a forced-air warming system was used to warm patients at 43℃ 10 min immediately before anesthesia induction. were kept using cotton thermal blankets min. measured tympanic every 15 from induction 90 Findings Since two deviated protocol, we data 38 (Prewarming [n?=?18]...

For anesthetic management during renal transplantation, it is necessary to maintain the blood flow and function of transplanted kidney by performing massive fluid stabilizing pressure. We report for transplantation with a less-invasive circulatory monitoring system (Edwards Life Sciences Co., Ltd., Irvine, California, U.S.A.). In November 2010, was started in our hospital, performed 6 patients. first patient, fluid/circulatory conducted connecting standard arterial line central venous (CV)...

Anti-cancer pharmaceuticals frequently have adverse side effects on patients such as gastrointestinal involvement limiting their clinical applications. These may be controlled by nutritional interventions, however, there are few studies that shown any mechanistic effects. In this study, we examined of diet enhanced with eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) 5-fluorouracil (5-FU)-induced intestinal impairment immunity in mice. C57Bl6 mice were randomized to control diet, +...

This study investigated plasma concentrations of substance P (SP) in patients undergoing general anesthesia (GA) and postoperative nausea vomiting (PONV). prospective, observational, cohort included 23 who underwent scheduled surgery under anesthesia. Blood was collected from the radial artery at predetermined time points (15-30 mins prior anesthesia, 15-30 after surgery/GA, 24 h surgery). PONV, SP concentrations, risk factors, analgesics used were measured.Nine experienced PONV. In without...

A PediaSatTM oximetry catheter (PediaSat: Edwards Lifesciences Co., Ltd., Irvine, CA, U. S. A.), which facilitates continuous measurement of central venous oxygen saturation (ScvO2), may be useful for surgery pediatric congenital heart disease. We used PediaSat during a bidirectional Glenn shunt. The patient was 13-month-old boy. Under diagnosis left single ventricle (pulmonary atresia, right ventricular hypoplasia, atrial septal defect) and residual aortic arch/left superior vena cava,...

We investigated the effectiveness of ClearSight system for hemodynamic management during kidney transplantation a recipient. The recipient was to receive transplant from his mother under general anesthesia. used continuous noninvasive finger‐cuff‐based monitoring blood pressure, provided by system, and stroke volume variation predict fluid responsiveness. balanced anesthetic technique stringent standards ensure successful outcome patient. This case demonstrated that has potential improve...