A5036092515- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Chronic Myeloid Leukemia Treatments
- Immune Response and Inflammation
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Mesenchymal stem cell research
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Plant Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- Advancements in Battery Materials
- Lymphoma Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- CAR-T cell therapy research
- Cancer therapeutics and mechanisms
- Cancer-related gene regulation
- Bone and Joint Diseases
- NF-κB Signaling Pathways
- Virus-based gene therapy research
- Neutropenia and Cancer Infections
- Sarcoma Diagnosis and Treatment
Kobe University
2021-2025
Kobe Children's Hospital
2016-2024
Hitachi General Hospital
2024
Children's Cancer Center
2022
Nagasaki University
2020
Daiichi-Sankyo (Japan)
2016-2020
Kyoto University Hospital
2012-2020
RIKEN Center for Biosystems Dynamics Research
2020
Kyoto University
2015-2017
Iwate University
2008-2013
Granulopoiesis is tightly regulated to meet host demands during both "steady-state" and "emergency" situations, such as infections. The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) plays critical roles in emergency granulopoiesis, but the precise developmental stages which C/EBPβ required are unknown. In this study, a novel flow cytometric method was developed that successfully dissected mouse bone marrow cells undergoing granulopoiesis into five distinct subpopulations...
Steady‐state hematopoiesis responds to extracellular stimuli meet changing demands and also pathologically altered intracellular signaling. Granulocyte production increases following infection or in response cytokine stimulation, activation of the CCAAT /enhancer‐binding protein β (C/ EBP β) transcription factor is required for such stress‐induced granulopoiesis, whereas C/ α plays a critical role maintaining steady‐state granulopoiesis. Different roles these factors different modes are...
Parathyroid hormone (PTH) stimulates hematopoiesis in mouse models. The involvement of osteoblasts this process has been well investigated; however, the effects PTH on human and bone marrow mesenchymal stromal cells (BM-MSCs) are unclear. Here, we show that BM-MSCs contribute to hematopoiesis-stimulating via upregulation cadherin-11 (CDH11). When culture-expanded were stimulated with PTH, their ability expand cocultured CD34(+) hematopoietic progenitor (HPCs) was enhanced. Furthermore, when...
Abstract The transcription factor CCAAT enhancer-binding protein β (C/EBPβ) is required for stress-induced granulopoiesis at the level of hematopoietic stem/progenitor cells (HSPCs); however, its role and mechanisms action in HSPCs are unknown. In this study, we assessed regulation functions C/EBPβ HSPCs, especially under stress conditions. After 5-fluorouracil treatment or bone marrow transplantation, Cebpb−/− exhibited impaired cell-cycle activation myeloid differentiation early late...
Monitoring of several sets neuroblastoma-associated mRNAs (NB-mRNAs) by real-time quantitative PCR (qPCR) can be used to evaluate minimal residual disease in NB patients. Droplet digital (ddPCR) is an adaption qPCR that potentially provides simpler and more reproducible detection low levels mRNAs. However, whether patients monitored ddPCR using a set NB-mRNAs not yet tested. In this study, 208 bone marrow (BM) 67 peripheral blood samples were retrospectively collected from 20 high-risk with...
Increasing attention has been paid to human γδ T cells expressing Vγ2Vδ2 cell receptor (also termed Vγ9Vδ2) in the field of cancer immunotherapy. We have previously demonstrated that a newly synthesized tetrakis-pivaloyloxymethyl 2-(thiazole-2-ylamino)ethylidene-1,1-bisphosphonate (PTA) efficiently expanded peripheral blood purities up 95% - 99% 10 11 days. In present study, we first examined effect PTA on farnesyl diphosphate synthase (FDPS) using liquid chromatography mass spectrometry...
Structural relaxation has been investigated on LixNiO2 and Lix(Ni0.933Co0.031Al0.036)O2 after the electrochemical lithium extraction to x ≤ 0.12. These analyses have carried out using X-ray diffraction coupled with Rietveld analysis assuming two phases (H2 H3) co-existence symmetry. For all compositions of LixNiO2, mole fraction H3 phase decreases time accompanied by reduction c-axis, while H2 retains c-length almost constant. Therefore, excessively formed at process partly transforms into...
Abstract The dismal prognosis of pediatric acute myeloid leukemia (AML) relapsing after hematopoietic stem cell transplantation (HSCT) requires exploration novel strategies to prevent relapse. Azacitidine (AZA) maintenance therapy could potentially reduce the recurrence rate post HSCT. Here, we presents cases three children with high‐risk AML HSCT who were treated low‐dose AZA therapy, demonstrating feasibility this therapy. Currently, all are in complete remission for 13–41 months despite...
We experienced a case in which long-term use of nivolumab patient with history ulcerative colitis led to disease control gastric cancer. The is 77-year-old man. had and remained remission on mesalazine 1500 mg/d. With continuous monitoring, could be continued up 16 courses, but was withdrawn due the appearance diarrhea (grade 1) bloody stools, relieved prednisolone (PSL) 40 After two more 3) appeared again, improved PSL 60 mg/d increased dose mesalazine. It difficult distinguish whether that...
Abstract The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) regulates the differentiation of a variety cell types. Here, role C/EBPβ expressed by bone marrow mesenchymal stromal cells (BMMSCs) in B-cell lymphopoiesis was examined. size precursor population reduced C/EBPβ-knockout (KO) mice. When from C/EBPβ-KO mice were transplanted into lethally irradiated wild-type (WT) mice, which provide normal microenvironment, restored to level equivalent that generated WT cells. In...
BRAF V600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis1][12][13][14][15] However, the mutation status and clinical impact BM (BMD) at level are not fully understood.In order to clarify measurable BMD LCH, we investigated somatic mutations paired tumor samples using a sensitive detection system.We retrospectively performed mutational analyses 59 LCH tumors by targeted amplicon sequencing custom-designed primers subsequently analyzed 41...