A5009748453- Noise Effects and Management
- Sarcoma Diagnosis and Treatment
- Hearing Loss and Rehabilitation
- Blood groups and transfusion
- Biochemical Analysis and Sensing Techniques
- Glioma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Enzyme Structure and Function
- Pancreatic and Hepatic Oncology Research
- Meat and Animal Product Quality
- Cancer, Hypoxia, and Metabolism
- Geriatric Care and Nursing Homes
- Chromatin Remodeling and Cancer
- Liver Disease Diagnosis and Treatment
- Fluid dynamics and aerodynamics studies
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Neuroblastoma Research and Treatments
- Advanced Chemical Sensor Technologies
- Immunodeficiency and Autoimmune Disorders
- Cancer Mechanisms and Therapy
- Mycobacterium research and diagnosis
- Epilepsy research and treatment
- Folate and B Vitamins Research
- Frailty in Older Adults
Yamagata University
2024
Gunma Saiseikai Maebashi Hospital
2024
Utsunomiya University
2024
Gunma University
2009-2023
Gunma University Hospital
2018-2022
Mie University
2021
Social Welfare Department
2019
Heisei College of Health Sciences
2018
Kanazawa University
2017
Kyushu University
2008-2016
Abstract BACKGROUND Active suppression by CD4 + CD25 regulatory T cells plays an important role in the down‐regulation of response to foreign and self antigens. Experimental tumor models mice revealed that inhibit antitumor immune responses. The purpose current study was demonstrate possible involvement system impairment patients with gastrointestinal malignancies. METHODS phenotypes lymphocytes, particularly those cells, were analyzed peripheral blood 149 malignancies ascites 7 peritoneal...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, Structure, and Chemistry of a Dinuclear Tetrahydride-Bridged Complex Ruthenium, (.eta.5-C5Me5)Ru(.mu.-H)4Ru(.eta.5-C5Me5). C-H Bond Activation Coupling Reaction Ethylene on ComplexesHiroharu Suzuki, Hideki Omori, Dong Hwan Lee, Yuka Yoshida, Masahiko Fukushima, Masako Tanaka, Yoshihiko Moro-okaCite this: Organometallics 1994, 13, 4, 1129–1146Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published...
Abstract Central nervous system high‐grade neuroepithelial tumors with BCOR alteration (CNS HGNET‐BCOR) are a recently reported rare entity, identified as small fraction of previously institutionally diagnosed so‐called CNS primitive neuroectodermal tumors. Their genetic characteristic is somatic internal tandem duplication in the 3′ end ( ITD), which has also been found clear cell sarcomas kidney (CCSK) and soft tissue undifferentiated round sarcomas/primitive myxoid mesenchymal infancy...
Vascular endothelial growth factor (VEGF) is implicated as a molecular mediator for adult neurogenesis and behavioral effects of antidepressant drugs. However, these potential roles VEGF in the CNS have not been clarified model animals. Here we created transgenic mice overexpressing short active variant VEGF-A (VEGF120) forebrain. Expression VEGF120 significantly enhanced cell proliferation angiogenesis, exemplified by formation an enlarged reddish brain. Adult hippocampus was markedly...
Efficient cold-chain delivery is essential for maintaining a sustainable global food supply. This study used metabolomic analysis to examine meat quality changes during the “wet aging” of crossbred Wagyu beef cold storage. The longissimus thoracic (Loin) and adductor muscles (Round) hybrid beef, cross between Japanese Black Holstein–Friesian breeds, were packaged in vacuum film refrigerated up 40 days. Sensory evaluation indicated an increase umami kokumi taste owing wet aging. Comprehensive...
Background: Japanese Black beef is known for its high intramuscular fat content, an important factor in distinctive Wagyu aroma. Wet aging, which involves vacuum-packing meat and storing it at low temperatures, enhances flavor, texture, tenderness essential maintaining improving quality. In this study, changes metabolites lipid profiles were investigated during the wet aging of Holstein beef. Methods/Results: Gas chromatography-mass spectrometry identified 113 94 beef, with significant...
It is becoming increasingly important for clinicians to identify a safer intramuscular (IM) injection site in the deltoid muscle because of possible complications following vaccine administration IM injections. We herein examined 4 original sites located on perpendicular line through mid-acromion establish site. Thirty healthy volunteers participated this study and distances from our some anatomical landmarks their left arms were measured. Ultrasonography (US) was also performed measure...
Abstract We evaluated the enhancement of cured meat taste during maturation by sensory analysis. focused on heat‐stable sarcoplasmic fraction (HSSF) to identify factors related taste. Because dry matter HSSF contained more than 30% nitrogen, nitrogen compounds such as free amino acids, small peptides and adenosine triphosphate‐related seemed be important components HSSF. The samples with for 2 h exhibited same profile ones without 168 h. Therefore, changes in amount fractions were examined...
ABSTRACT For exhaustive detection of diarrheagenic Escherichia coli , we previously developed a colony-hybridization method using hydrophobic grid-membrane filters in combination with multiplex real-time PCR. To assess the role domestic animals as source atypical enteropathogenic E. (aEPEC), total 679 samples (333 from foods, fecal 227 animals, and 119 healthy people) were examined. Combining 48 strains isolated patients carriers, 159 aEPEC classified by phylogroup, virulence profile,...
The mechanism of theca cell layer formation in mammalian ovaries has not been elucidated; one reason is that there no follicle culture system can reproduce vitro. Therefore, a three-dimensional required. A collagen gel was used the system. To determine optimum conditions for formation, effects hormonal treatment and types co-cultured with follicles were examined. In addition, immunohistochemistry to examine properties layers formed outermost part follicles. Follicles maintained shape grew...
In the present study, in order to reveal novel adverse effects of ultrafine particles (UFP) on central nervous system, nanoparticle-rich diesel exhaust (NRDEP; count mode diameter, 21.45 nm) emotional behavior, learning capability and brain neurotransmitter levels were studied rats by intranasal instillation (iNI). NRDEP (10 50 µg/rat) was instilled into 2-week old infant, male once a week for 4 weeks. Spontaneous motor activity measured observed be inverse dose level. active avoidance tests...
Objectives: To evaluate the effectiveness of traditional Chinese medicine, specifically herbal formulation Bu-yang-huan-wu-tang, for treating epilepsy stemming from cerebrovascular dysfunction. Subjects: Three adult patients with refractory to standard antiepileptic medications were involved. Results: All three showed substantial improvement in frequency and severity seizures after Bu-yanghuan- wu-tang was added conventional medical treatment. Conclusions: Decrease seizure epileptic achieved...
The kidney is one of the major loci for expression cystathionine β-synthase (CBS) and γ-lyase (CTH). While CBS-deficient (Cbs(-/-)) mice display homocysteinemia/methioninemia severe growth retardation, rarely survive beyond first 4 wk, CTH-deficient (Cth(-/-)) show homocysteinemia/cystathioninemia but develop with no apparent abnormality. This study examined renal amino acid reabsorption in those mice. Although both 2-wk-old Cbs(-/-) Cth(-/-) had normal architecture, their serum/urinary...
Enterotoxigenic Escherichia coli (ETEC) serotype O169:H41 has been an extremely destructive epidemic ETEC type worldwide. The strain harbors a large unstable plasmid that is regarded as responsible for its virulence, although etiology remained unknown. To examine genetic background specifically on the retention and responsibility in unique adherence to epithelial cells enterotoxin production, complete sequence of plasmid, pEntYN10, purified from was determined. length 145,082 bp; GC content...
A spatiotemporal understanding of gene function requires the precise control expression in each cell. Here, we use an infrared laser–evoked operator (IR-LEGO) system to induce at single-cell level moss Physcomitrium patens by heating a living cell with IR laser and thereby activating heat shock response. We identify irradiation conditions that provide higher inducibility lower invasiveness changing power duration. Furthermore, quantitatively characterize induction profile response using...
Abstract Electrical impedance spectroscopy is expected to use for quality estimation of agricultural product. In this study, changes in moisture content, porosity and electrical mechanical properties sweet potato heated hot water at 50, 55, 60, 65, 70 °C were investigated. Additionally, the tissue structure was scanned by X‐ray computerized tomography (CT). As a result, sample decreased with treatment time every temperature while content changed only °C. This decrease greatly affected...
Notch signaling is an evolutionarily conserved mechanism that controls many cell-fate specifications through local cell-cell interactions. The core mechanisms of activation and its subsequent intracellular are well understood. Various cellular functions required for the regulation signaling. Among them, endocytosis ligands important suppression endosomal sorting complex transport (ESCRT) proteins to sort ubiquitinated membrane proteins, such as Notch, into early endosomes. A loss-of-function...
Abstract The genetic concordance and heterogeneity of the two components pulmonary carcinosarcoma (PCS), carcinoma, sarcoma, have not been fully elucidated because its rare occurrence. We performed targeted sequencing carcinoma sarcoma four PCSs to identify similarities differences. Formalin‐fixed paraffin‐embedded tissue samples were macroscopically or microscopically dissected. DNA was extracted from each component, alterations analyzed separately. Moreover, we RNA‐seq analysis on both one...