A5040661303- Apelin-related biomedical research
- Neuroendocrine regulation and behavior
- Renin-Angiotensin System Studies
- Neuroscience of respiration and sleep
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neurogenesis and neuroplasticity mechanisms
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Neonatal and fetal brain pathology
- Ichthyology and Marine Biology
- Mercury impact and mitigation studies
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Fish biology, ecology, and behavior
- Anatomy and Medical Technology
- Infant Health and Development
- Diet, Metabolism, and Disease
- Geology and Paleoclimatology Research
- Orthopedic Surgery and Rehabilitation
- Nuclear Receptors and Signaling
- Advanced biosensing and bioanalysis techniques
- Peripheral Nerve Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Zebrafish Biomedical Research Applications
- Aging and Gerontology Research
Tottori University
2003-2024
Hiroshima University
2000-2014
Kyushu University
2006-2007
Vascular endothelial growth factor (VEGF) is implicated as a molecular mediator for adult neurogenesis and behavioral effects of antidepressant drugs. However, these potential roles VEGF in the CNS have not been clarified model animals. Here we created transgenic mice overexpressing short active variant VEGF-A (VEGF120) forebrain. Expression VEGF120 significantly enhanced cell proliferation angiogenesis, exemplified by formation an enlarged reddish brain. Adult hippocampus was markedly...
Recent increases in fructose consumption have raised concerns about the potential adverse intergenerational effects of excess intake. In present study, we investigated whether maternal intake affects hippocampal function offspring. Female Sprague-Dawley rats were divided into 3 experimental groups: one group received distilled water, 20% and glucose water addition to standard chow during gestation lactation. Hippocampal offspring was evaluated by using novel object recognition fear...
A fluorescent dye, Evans blue (EB), was injected into the following seven drinking‐associated muscles of Japanese eel Anguilla japonica : sternohyoid, third branchial, fourth opercular, pharyngeal, upper oesophageal sphincter and body muscles. The sternohyoid muscle promotes ‘ingestion’, remaining contribute to ‘swallowing’. All neurones stained by EB were located ipsilaterally in caudal medulla oblongata (MO) eel. Neurones projecting identified as those spino‐occipital motor nucleus (NSO),...
The whole brain atlas of the eel was constructed in first place by Kluver-Barrera’s staining. Eighty one nuclei and thirty fiber tracts were identified present study. Basically, topology similar to that rainbow trout, goldfish, zebrafish, catfish. However, some details differed from those other teleosts. parvocellular preoptic nucleus (PP) not subdivided, whereas anterior PP is distinguished posterior part zebrafish trout. intermediate thalamic distinguished, it paraventricular organ (PVO)...
Background Estrogen, a class of female sex steroids, is neuroprotective. Estrogen synthesized in specific areas the brain. There possibility that de novo estrogen exerts protective effect brain, although direct evidence for neuroprotective function brain-synthesized has not been clearly demonstrated. Methylmercury (MeHg) neurotoxin induces neuronal degeneration central nervous system. The neurotoxicity MeHg region-specific, and molecular mechanisms selective are well defined. In this study,...
In Japan, some nursing and health science universities that train nurses and/or clinical laboratory technicians have a curriculum in which students observe medical performing cadaver dissection. Observing dissection is believed to affect the formation of student's professional identity. This study aimed investigate effects observing on identity find an effective educational support system for developing identity.Sophomores majoring or were asked complete questionnaire with scale before after...
Intravenous administration of eel angiotensin II (eANG II), histamine (HA), serotonin (5-HT), acetylcholine (ACh) or carbachol (CCh), mammalian substance P (mSP) and isoproterenol (β-adrenoceptor agonist) enhanced drinking rate in the seawater eels. The dipsogenic effects HA 5-HT seem to be due ANG synthesis, because these were completely blocked by captopril, an inhibitor converting enzyme (ACE). Captopril eANG I effect, but not suggesting existence ACE 800 μl Hemorrhage also water intake,...
To clarify neuronal networks controlling swallowing water, inhibitory neurotransmitters were searched on the glossopharyngeal–vagal motor complex (GVC) of medulla oblongata (MO), which is proposed as a nucleus swallowing. Spontaneous firing (20–30 Hz) in GVC was inhibited by adrenaline (AD), noradrenaline (NA) and dopamine (DA). The effects these catecholamines (CAs) dose-dependent, AD NA completely blocked phenoxybenzamine or yohimbine, indicating that at least two CAs act same receptor,...
Background: Estrogen, a class of female sex steroids, is neuroprotective.Estrogen synthesized in specific areas the brain.There possibility that de novo estrogen exerts protective effect brain, although direct evidence for neuroprotective function brain-synthesized has not been clearly demonstrated.Methylmercury (MeHg) neurotoxin induces neuronal degeneration central nervous system.The neurotoxicity MeHg regionspecific, and molecular mechanisms selective are well defined.In this study,...
Abstract Introduction Although the hippocampus (HIP) is thought impermeable to blood‐borne proteins because of integrity blood–brain barrier (BBB), it was recently suggested be susceptible hydrophilic hormones. The present study determined accessibility signal molecules such as hormones hippocampal neurons in physiologically normal rats. Methods As a probe for accessibility, Evans blue dye (EB) that rapidly binds albumin (Alb), which BBB, injected intravenously. To increase vascular...
In terrestrial vertebrates, the hippocampus plays a major role in spatial cognition. Recent developmental, anatomical, and histological studies suggest that ventral region of lateral part dorsal telencephalic area (Dlv) teleost fishes is homologous to vertebrates. We hypothesized fish species with higher cognitive demands have more highly developed Dlv compared closely related relatively lower demands. The selected for this study were Favonigobius gymnauchen, Istigobius hoshinonis,...