A5062869813- Eosinophilic Esophagitis
- Wind and Air Flow Studies
- Soft Robotics and Applications
- Esophageal and GI Pathology
- Congenital heart defects research
- Robotic Path Planning Algorithms
- Pediatric Hepatobiliary Diseases and Treatments
- Tracheal and airway disorders
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Aerodynamics and Fluid Dynamics Research
- Congenital Diaphragmatic Hernia Studies
- Treatment of Major Depression
- Folate and B Vitamins Research
- Fluid Dynamics and Turbulent Flows
- Receptor Mechanisms and Signaling
- Eosinophilic Disorders and Syndromes
- Robotics and Sensor-Based Localization
- Autism Spectrum Disorder Research
- Non-Invasive Vital Sign Monitoring
- Robotic Locomotion and Control
- Bipolar Disorder and Treatment
- Teleoperation and Haptic Systems
- Organ Transplantation Techniques and Outcomes
Gunma Children's Medical Center
2015-2025
Keio University
2021-2023
Ashikaga Red Cross Hospital
2022-2023
Kokura Memorial Hospital
2023
Keio University Hospital
2023
Tokushima University
2014-2017
Albert Einstein College of Medicine
2015-2017
Tokyo University of Agriculture and Technology
2006
Saitama Children's Medical Center
2004-2005
The Open University of Japan
2003
Abstract Central nervous system high‐grade neuroepithelial tumors with BCOR alteration (CNS HGNET‐BCOR) are a recently reported rare entity, identified as small fraction of previously institutionally diagnosed so‐called CNS primitive neuroectodermal tumors. Their genetic characteristic is somatic internal tandem duplication in the 3′ end ( ITD), which has also been found clear cell sarcomas kidney (CCSK) and soft tissue undifferentiated round sarcomas/primitive myxoid mesenchymal infancy...
Karyopherin alpha 2 (KPNA2) has been reported to be associated with cancer aggressiveness and treatment resistance via transporting several cargo proteins into the nucleus, such as cancer-promoting E2F DNA repair-related MRN complex. Recent studies have highlighted KPNA2 functions in tumorigenesis progression of various cancers. However, importance expression yet elucidated clinical neuroblastoma patients. This study aimed analyze impact neuroblastoma.
The serotonin transporter (5HTT) may be associated with the pathogenesis of major depressive disorder (MDD). 5HTT‐linked polymorphic region (5HTTLPR) genotype determine how levels 5HTT mRNA are influenced by promoter methylation. We examined association gene methylation, which influences expression, and 5HTTLPR before antidepressant treatment expression after treatment. aims this study were (1) to investigate between methylation or in leukocytes depression (2) a possible effect on clinical...
Abstract Sleep disturbance is a common symptom of psychiatric and neurodevelopmental disorders and, especially in childhood, can be precursor to various mental disorders. However, the genetic etiology illness that contributes sleep during childhood poorly understood. We investigated whether polygenic features are associated with childhood. conducted risk score (PRS) analyses by utilizing large-scale genome-wide association studies (GWASs) ( n = 46,350–500,199) five major (autism spectrum...
Objectives To elucidate the molecular effects of lithium, we studied global gene expression changes induced by lithium in leukocytes from healthy subjects. Methods Eight male subjects participated this study. Lithium was prescribed for weeks to reach a therapeutic serum concentration. Leukocyte counts and concentrations were determined at baseline (before medication), after 1 2 medication stopping medication. Gene profiling performed each time point using Agilent G4112F Whole Human Genome...
Here we report de novo non-synonymous single-nucleotide variants (SNVs) by conducting whole exome sequencing of 18 trios consisting Japanese patients with sporadic schizophrenia and their parents. Among nine SNVs, explored the functional impact mutation in TBL1XR1 [c.30 C > G (p.Phe10Leu)], a gene previously found to be associated autism spectrum disorder epilepsy. Protein structural analysis revealed that Phe10Leu may decrease stability protein. We demonstrate alters interaction N-CoR...
Background Selective serotonin reuptake inhibitors (SSRI) are established first-line pharmacological treatments for obsessive-compulsive disorder (OCD), while antipsychotics used as an augmentation strategy SSRI in OCD patients who have either no response or a partial to treatment. The goal of the present study was identify genetic variants and pathways that associated with long-term clinical antipsychotics. Methods We first performed genome-wide association 96 examine contributing...