A5031476989- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- Dermatology and Skin Diseases
- Bee Products Chemical Analysis
- Healthcare and Venom Research
- Cardiac Imaging and Diagnostics
- Burn Injury Management and Outcomes
- Diabetic Foot Ulcer Assessment and Management
- Lymphatic System and Diseases
- Skin Protection and Aging
- Tendon Structure and Treatment
- Venous Thromboembolism Diagnosis and Management
- Plasma Applications and Diagnostics
- Diagnosis and Treatment of Venous Diseases
- Shoulder Injury and Treatment
- Thermoregulation and physiological responses
- Intramuscular injections and effects
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Cardiovascular Function and Risk Factors
- Central Venous Catheters and Hemodialysis
- Orthopedic Surgery and Rehabilitation
- Sympathectomy and Hyperhidrosis Treatments
- Cardiac, Anesthesia and Surgical Outcomes
Kanazawa University
2016-2025
Aichi Medical University
2013-2024
Salinas Valley Memorial Healthcare System
2021
Scripps Clinic
2015
Shijonawate Gakuen University
2011-2014
Osaka Electro-Communication University
2011-2014
Objective To evaluate the survival and function of hepatocytes (HCs) on a novel three-dimensional (3D) synthetic biodegradable polymer scaffold with an intrinsic network interconnected channels under continuous flow conditions. Summary Background Data The authors' laboratory has investigated HC transplantation using 3D polymers as scaffolding alternative approach to treatment end-stage liver disease. Previous studies have demonstrated HCs transplanted discs in peripheral tissue sites partial...
The swabbing and tape-stripping methods have traditionally been used for collecting skin microbiome samples bacterial analysis, although no reports compared the outcome of these bacteria. Our purpose was to show differences in microbial composition between collected using methods, by both next generation sequencing culture studies. were processed a sequence-based analysis study. next-generation results showed that bacteria method comparable those method. In study, greater number wider...
While there is an urgent need worldwide to establish methods that prevent diabetic foot ulcers, the effectiveness of a prevention protocol using thermography has been reported. As number patients in Indonesia increasing, online program for wound care specialists was developed disseminate this protocol. The present study evaluated impact on specialists' knowledge ulcer thermography. This single-group quasi-experimental conducted cooperation with Indonesian Wound Enterostomal Continence Nurses...
It is becoming increasingly important for clinicians to identify a safer intramuscular (IM) injection site in the deltoid muscle because of possible complications following vaccine administration IM injections. We herein examined 4 original sites located on perpendicular line through mid-acromion establish site. Thirty healthy volunteers participated this study and distances from our some anatomical landmarks their left arms were measured. Ultrasonography (US) was also performed measure...
Estrogen promotes cutaneous wound healing in ovariectomized (OVX) female mice. However, the effects of topical estrogen application on wounds remain unclear. Therefore, aim this study was to compare with standard treatment methods. Eight-week-old C57BL/6J mice underwent OVX and received two full-thickness four weeks later. Mice were divided into three groups: estradiol benzoate (EB) (0.75 μg/g/day) treatment, subcutaneous (E2) pellets (0.05 mg, 21 days), E2 (0.01 g/day) skin application....
Since lymphedema rarely develops in the mouse hindlimb, underlying mechanisms remain unclear. We herein investigated resolution of chronic hindlimb mice using a Near-Infrared Fluorescence (NIRF) imaging system. Nineteen 7-28-week-old BALB/c male and female were injected with two dyes for lymphography dissection. Lymphadenectomy was performed on six to completely obstruct lymph flow hindlimb. Edematous changes both hindlimbs compared until 60 days after surgery. The NIRF system detected three...
Although many previous studies reported that honey promotes wound healing, no study has examined the effects of Japanese honey. The aim this was to investigate three types honey, Acacia, Buckwheat flour, and Chinese milk vetch on healing in comparison with hydrocolloid dressing. Circular full-thickness skin wounds were produced male mice. or dressing applied daily mice for 14 days. ratio area group increased initially inflammatory early proliferative phases then decreased rapidly heal...
The anatomical safety of intramuscular injections at the deltoid and ventrogluteal sites has been investigated; however, relationship between injection in thigh major blood vessels nerves remains unclear. We aimed to compare rectus femoris vastus lateralis with those identify safe thigh. Twenty-seven young adult volunteers were recruited, thicknesses subcutaneous tissue muscle as well number present evaluated two on deltoid, ventrogluteal, using ultrasound equipment. right thighs 24 cadavers...
With the increase in older populations, number of bedridden patients is becoming a matter concern. Skin microbiome and skin physiological functions are known to change according lifestyle community; however, such changes case movement- cleaning-restricted have not yet been revealed. To address this issue, we analyzed functions, including pH, hydration, sebum level, transepidermal water loss (TEWL), patients, compared with those ambulatory young individuals. For analysis, enrolled 19 healthy...
A simple technique is tested to improve the contractile effect of a cold plasma jet on acute wounds mice. Distilled water order microliters dropped onto before treatment. To assess fate water, an infrared thermal imager applied. evaluate healing effect, macroscopic and immunohistological studies are conducted. Regarding wound we show that combination treatment with seemed have greater than alone. Plasma may modify surface through such chemically physically. The histological stiffness during...
Objective The aim of the present observational study was to identify safe and suitable venipuncture sites for nursing in clinical setting using ultrasonography measure depth cross-sectional area each superficial vein before after tourniquet application as well distance between median nerve or brachial artery. Methods Results Twenty healthy volunteers (21.8 [0.6] y) were recruited. visible rate 65% basilic vein, 90% 95% cubital 80% cephalic vein. significantly larger than that smaller nerve....
Female sex hormones are beneficial effects for wound healing. However, till date, whether topical estrogen application can promote cutaneous healing in diabetes remains unclear. Therefore, the present study aimed to validate effect of on a type 2 db/db mice model. In total, 22 female with and eight C57BL/6J were subjected two full-thickness injuries. The divided into db/db, + estrogen, vehicle, wild (WT) groups. Wound was assessed until day 14. group had significantly high area ratio (wound...
Abstract This study investigated the effect of 17β‐estradiol on wound healing in 40‐week ovariectomised female mice. Thirty‐six‐week‐old mice were divided into three groups: medication with after ovariectomy (OVX + 17β‐estradiol), (OVX) and sham (SHAM). The received two full‐thickness wounds, OVX group was administered at 0·01 g/day until healing. In group, ratio area significantly smaller than those SHAM groups days 1–3, 5, 6, 8–12 9–12, respectively, numbers neutrophils macrophages 3 7,...
Cutaneous wound healing is delayed by protein malnutrition (PM). On the other hand, estrogen promotes cutaneous its anti-inflammatory and cell proliferation effects. Therefore, we hypothesized that administration in protein-malnourished ovariectomized (OVX) female mice might improve inflammatory response promote as well normal nutrition. To test this hypothesis, used full-thickness excisional wounds Control SHAM, PM OVX OVX+17β-estradiol mice. The diet included 200 g/kg 30 protein. ratio of...
The aim of this study was to evaluate the effect combined use Japanese honey and hydrocolloid dressing (HCD) on cutaneous wound healing. Mice were divided into four groups: Acacia (Japan) + HCD, Manuka (New Zealand) Chinese milk vetch HCD (control) groups. mice received two full-thickness wounds. wounds group covered with whereas those other groups treated 0.1 mL relevant type honey, before being HCD. Wound area significantly smaller in than day 13 days 8-14, respectively. Moreover, compared...
Topical estrogen application to wounds is effective in promoting cutaneous wound healing. However, whether it promotes healing delayed associated with advanced age remains be elucidated. This study aimed evaluate the effect of topical 80-week-old female mice. C57BL/6J mice aged 82–85 and 12 weeks old were submitted two full-thickness wounds. Mice divided into four groups: group, treatment group (aged-E), vehicle (aged-vehicle), young group. Wound was observed until day 14. In area ratio...
This study aimed to clarify the effects of honey on acute-phase deep burn wounds. Two wounds were created mice which divided into four groups: no treatment, silver sulfadiazine, manuka honey, and Japanese acacia honey. Wound sizes calculated as expanded wound areas sampled 30 minutes 1-4 days after wounding for histological observation. The sections subjected hematoxylin eosin immunohistological staining detect necrotic cells, apoptotic neutrophils, macrophages. treatment group formed a...
Although lymphedematous skin exhibits delayed wound healing, little is known about lymph drainage during healing. We investigated the healing process in presence of lymphatic dysfunction.The right inguinal nodes (iLNs) and surrounding tissue were excised each mouse (the operation side), a sham was performed left hindlimb control side). The next day, full-thickness wounds made on both hindlimbs. exhibited acute edema until day 3; however, it started to improve after 4, area epithelialization...