A5041517615- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Metabolism, Diabetes, and Cancer
- Prostate Cancer Treatment and Research
- Pancreatic function and diabetes
- Renal and Vascular Pathologies
- Prostate Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- MRI in cancer diagnosis
- Infectious Diseases and Tuberculosis
- Ureteral procedures and complications
- Venous Thromboembolism Diagnosis and Management
- Prion Diseases and Protein Misfolding
- Vascular anomalies and interventions
- Photodynamic Therapy Research Studies
- Hernia repair and management
- Radiopharmaceutical Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
Kobe City Medical Center General Hospital
2002-2025
Kyoto University
1992-2025
Ehime University
2024
Osaka Rosai Hospital
2015-2023
Kyoto University Hospital
2017-2022
Media Working Group
2021
RIKEN Center for Emergent Matter Science
2021
Tokyo Medical and Dental University
2021
DMG Mori (Japan)
2018
Ijinkai Takeda General Hospital
2013-2017
This study evaluated the impact of aspirin on biochemical recurrence (BCR) rate following robot-assisted radical prostatectomy (RARP) in patients. A database search identified patients who underwent RARP for pT2-3N0M0 disease at any 25 centers between 2011 and 2022, categorized into (n = 350) control groups 5857). Adjustment by 1:1 propensity score matching (PSM) Mahalanobis distance (MDM) created 350 matched pairs. The effect BCR was analysis BCR-free survival. After PSM MDM, 3-year...
ABSTRACT Background High‐risk patients with prostate cancer (PC) frequently experience biochemical recurrence (BCR) after surgery. Thus numerous studies have investigated the efficacy of neoadjuvant therapies for high‐risk PC patients; however, no protocol has been established. This study aimed to assess effect androgen deprivation therapy combined low‐dose estramustine phosphate (EMP) on BCR compared (ADT) alone in high‐ and very PC. Methods retrospective targeted meeting National...
The objective of this study was to evaluate the efficacy and safety dose-dense gemcitabine cisplatin (ddGC) as neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC).
Abstract This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical prostatectomy. cohort used a database for prostatectomy at 23 tertiary centers nationwide between 2011 2022. Patients received thienopyridines (thienopyridine group) were compared with those aspirin monotherapy (aspirin group). The primary outcome was incidence complications....
Scope Dietary deprivation of essential amino acids (EAAs) in mammals is known to cause reductions food intake and body weight. The aim this study was determine whether how mice respond individual EAA species. Methods results any single (not non-EAA) led progressive weight loss the order Ile− > Val− Thr− Leu− Trp− His− Phe− Met− Lys−, which correlated with reduction intake. Decreased levels deprived EAAs as well increased all or some other were detected serum, although these differed among...
The molecular mechanism of insulin resistance induced by high-fructose feeding is not fully understood. present study investigated the role downstream signaling molecules phosphatidylinositol 3-kinase (PI3K) in insulin-stimulated skeletal muscle high-fructose-fed rats. Rats were divided into chow-fed and fructose-fed groups. results euglycemic clamp (insulin infusion rates: 6 mU/kg BW/min) showed a significant decrease glucose rate (GIR) metabolic clearance (MCR) rats compared with In...
Treatment of 3T3-L1 adipocytes with insulin resulted in activation 2-deoxyglucose transport activity and translocation glucose transporters (GLUT4 GLUT1) from the cytoplasmic space to plasma membrane. ML-9 (a myosin light chain kinase inhibitor) inhibited stimulation by 80% at 100 microM (IC50 = 27 microM) without affecting basal state. The inhibition was independent extracellular Ca2+ concentration almost fully reversible 40 ML-9. did not inhibit insulin-stimulated tyrosine phosphorylation...
We investigated whether phosphatidylinositol 3-kinase (PI3K) is phosphorylated and its specific activity increased by insulin stimulation in vivo using Fao cells antibodies raised against the 85 kDa subunit of PI3K, insulin-receptor substrate-1 (IRS-1), phosphotyrosine (pTyr). PI3K was detected immunoprecipitate produced with anti-PI3K at a basal state. The 2-3-fold stimulation, although protein concentration kinase immunoprecipitates same before after stimulation. Both anti-pTyr anti-IRS-1...
The kidney is one of the major loci for expression cystathionine β-synthase (CBS) and γ-lyase (CTH). While CBS-deficient (Cbs(-/-)) mice display homocysteinemia/methioninemia severe growth retardation, rarely survive beyond first 4 wk, CTH-deficient (Cth(-/-)) show homocysteinemia/cystathioninemia but develop with no apparent abnormality. This study examined renal amino acid reabsorption in those mice. Although both 2-wk-old Cbs(-/-) Cth(-/-) had normal architecture, their serum/urinary...
Objectives To assess the perioperative outcomes of robot‐assisted partial nephrectomy without renorrhaphy for cT 1b renal tumors compared with 1a. Methods From February 2015 to May 2018, 100 patients who underwent were included. We retrospectively reviewed medical records, and 66 34 1a tumors, respectively. Inner suture was carried out in opened collecting system or sinus, whereas parenchymal not. For hemostasis, soft‐coagulation used, absorbable hemostats placed on resection bed. Results...
Objectives To compare the perioperative and oncological outcomes of pure laparoscopic intracorporeal ileal conduit urinary diversion versus extracorporeal after radical cystectomy for bladder cancer in a multicenter cohort Japan. Method A total 455 patients who underwent carried out at 10 institutions were included this retrospective study. The data groups compared using propensity score matching method. Kaplan–Meier curves obtained to elucidate time ureteroenteric stricture, reoperation,...
Physical activity (PA) that includes an accumulated exercise regimen meets or exceeds a certain intensity reduces intrahepatic fat, leading to the improvement of nonalcoholic fatty liver disease (NAFLD) in afflicted patients. However, whether increase comprehensive PA, including activities daily living, contributes ameliorating pathophysiology NAFLD remains unclear. This study aimed examine PA improves function patients with NAFLD.The included 45 who underwent follow-up examinations at least...
Abstract Background To compare 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) with narrow-band imaging (NBI) for cancer detection during transurethral resection of bladder tumour (TURBT). Methods Between June 2018 and October 2020, 114 patients 282 lesions were included in the analysis. Patients orally administered 5-ALA (20 mg/kg) 2 h before TURBT. The was inspected white light (WL), PDD, NBI each patient, all areas positive by at least one method resected or biopsied....
This study was undertaken to examine if C-peptide (C) may interact with hexameric insulin and facilitate its disaggregation into the physiologically active monomeric form.Regular (I) or an analogue (IA) were injected s.c. in rats together C C-terminal pentapeptide (PP). I IA PP administered either as a physical mixture two separate depots. Whole body glucose utilization evaluated using euglycemic clamp technique. Phosphorylation of Akt/PKB GSK liver skeletal muscles ⁸⁶Rb⁺ uptake by L6 cells...
To assess the incidence of asymptomatic unruptured renal artery pseudoaneurysm (RAP) on contrast-enhanced computed tomography (CE-CT) after robot-assisted partial nephrectomy (RAPN) without parenchymal renorrhaphy.From May 2016 to December 2017, 78 patients underwent RAPN for tumors. Inner suture was performed in opened collecting system or sinus, whereas renorrhaphy not. For hemostasis, soft coagulation used, and absorbable hemostats were placed resection bed. CE-CT carried out within 7...
Objectives To assess the effect of optimal neoadjuvant chemotherapy at least three cycles cisplatin‐based regimen on oncological outcomes clinical stage T3 or higher bladder cancer treated with laparoscopic radical cystectomy. Methods Laparoscopic cystectomies carried out 10 institutions were included in this retrospective study. The patients who received and those did not receive compared using propensity score matching T3–4 T2 cohorts, separately. Results Of 455 screened, matched pairs 54...