A5007998286- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Urinary Bladder and Prostate Research
- Sarcoma Diagnosis and Treatment
- Renal and related cancers
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Advanced Radiotherapy Techniques
- Neuroendocrine Tumor Research Advances
- Renal Transplantation Outcomes and Treatments
- Testicular diseases and treatments
- Hormonal and reproductive studies
Kyoto University
2016-2025
Kyoto University Hospital
2016-2025
Kobe University
2025
Japanese Urological Association
2024
Shinshu University
2015-2024
Mitsubishi Electric (Japan)
2023-2024
Creative Commons
2023
RIKEN Center for Advanced Intelligence Project
2023
RIKEN Center for Integrative Medical Sciences
2023
Weatherford College
2023
Abstract Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu 1–3 . Here we identify metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized secreted by activated B plasma cells. We show that cell-derived promotes monocyte differentiation anti-inflammatory macrophages secrete interleukin-10 inhibit CD8 + T cell killer function....
PURPOSE Circulating tumor DNA (ctDNA) analysis is an alternative to tissue biopsy for genotyping in various cancers. We aimed establish a plasma ctDNA sequencing assay, then evaluate its clinical utility advanced urothelial cancer (UC). MATERIALS AND METHODS This study included 82 patients with muscle-invasive or metastatic UC. A total of 158 blood samples and 73 were sequenced using our designed panel covering 53 UC-relevant genes TERT promoter. investigated the association between...
Abstract A characteristic clinical course of a patient with micropapillary bladder cancer, rare histological variant high metastatic potential, is presented. An 80‐year‐old woman had locally advanced high‐grade cancer focal identified which was treated intra‐arterial chemotherapy radiation therapy. Standard follow‐ups involving cystoscopy cold‐cup biopsies and computed tomography could not detail the carcinoma; however, died carcinomatosis 20 months after treatment. At autopsy, carcinomas...
Objectives Immune checkpoint inhibitors and enfortumab vedotin have opened new avenues for sequential treatment strategies locally advanced/metastatic urothelial carcinoma (la/mUC). In the pre‐enfortumab era, many patients could not receive third‐line owing to rapid disease progression poor general status. This study aimed analyze real‐world practices la/mUC in Japan, with a focus on who do treatment. Methods We analyzed data 1023 diagnosed between January 2020 December 2021 at 54...
Abstract Liquid biopsy has emerged as a valuable and minimally invasive tool for real‐time detection of clinically actionable abnormalities across various cancer types. Its applicability is particularly compelling in the realm prostate cancer, where novel therapeutic agents, including those targeting DNA repair systems, are under development. Despite these advancements, challenges persist effectively screening enhancing risk stratification, determining optimal approaches treating advanced...
Abstract Background Lineage plasticity in prostate cancer primarily induces transdifferentiation of adenocarcinoma into neuroendocrine (NEPC). alteration is largely driven by epigenome and potentially reversible. Nonetheless, evidence supporting NEPC reversibility lacking materials derived from clinical specimens. Hence, we established KUCaP13, a novel cell line the tissue patient initially diagnosed with adenocarcinoma, which later recurred as NEPC. We aimed to prove cellular lineage...
More effective therapeutic approaches for castration-resistant prostate cancer (CRPC) are urgently needed, thus reinforcing the need to understand how tumors progress castration resistance. We have established a novel mouse xenograft model of cancer, KUCaP-2, which expresses wild-type androgen receptor (AR) and produces prostate-specific antigen (PSA). In this model, regress soon after castration, but then reproducibly restore their ability proliferate 1 2 months without AR mutation,...
Our previous animal and preliminary human studies indicated that bronchoscopy-guided cooled radiofrequency ablation (RFA) for the lung is a safe feasible procedure without major complications.The present study was performed to evaluate safety, effectiveness feasibility of computed tomography (CT)-guided bronchoscopy RFA in patients with medically inoperable non-small-cell cancer (NSCLC).Patients pathologically diagnosed NSCLC, who had no lymph node involvement or distant metastases...
Both the PI3K → Akt mTOR and mitogen-activated protein kinase (MAPK) signaling pathways are often deregulated in prostate tumors with poor prognosis. Here we describe a new genetically engineered mouse model of cancer which PI3K-Akt-mTOR is activated by inducible disruption PTEN, extracellular signal-regulated 1/2 (ERK1/2) MAPK expression BRAF(V600E) oncogene. These tissue-specific compound mutant mice develop lethal that inherently resistant to castration. bypass cellular senescence...
Although the prognosis for clinically localized prostate cancer is now favorable, there are still no curative treatments castration-resistant (CRPC) and, therefore, it remains fatal. In this study, we investigate a new therapeutic approach treatment of CRPC, which involves dual targeting major signaling pathway that frequently deregulated in disease. We found Akt and mTOR pathways with their respective inhibitors, MK-2206 ridaforolimus (MK-8669), highly effective inhibiting CRPC preclinical...
High-resolution matrix-assisted laser desorption/ionization imaging mass spectrometry (HR-MALDI-IMS) is an emerging application for the comprehensive and detailed analysis of spatial distribution ionized molecules in situ on tissue slides. HR-MALDI-IMS negative mode a range m/z 500–1000 was performed optimal cutting temperature (OCT) compound-embedded human prostate samples obtained from patients with cancer at time radical prostatectomy. 14 discovery set identified 26 as highly expressed...
Abstract The therapeutic landscape of castration-resistant prostate cancer (CRPC) has rapidly expanded. There is a need to develop noninvasive biomarkers guide treatment. We established highly sensitive method for analyzing androgen receptor gene ( AR ) copy numbers (CN) and mutations in plasma circulating cell-free DNA (cfDNA) evaluated the statuses patients with CRPC. amplification was detectable VCaP cell line amplified) genomic (gDNA) diluted 1.0% by digital PCR (dPCR). mutation were...
The use of immune checkpoint inhibitors to treat urothelial carcinoma (UC) is increasing rapidly without clear guidance for validated risk stratification. This multicenter retrospective study collected clinicopathological information on 463 patients, and 11 predefined variables were analyzed develop a multivariate model predicting overall survival (OS). was using an independent dataset 292 patients. Patient characteristics outcomes well balanced between the discovery validation cohorts,...
Abstract This study aimed to develop a versatile automatic segmentation model of bladder cancer (BC) on MRI using convolutional neural network and investigate the robustness radiomics features automatically extracted from apparent diffusion coefficient (ADC) maps. two-center retrospective used multi-vendor MR units included 170 patients with BC, whom 140 were assigned training datasets for modified U-net five-fold cross-validation 30 test assessment performance reproducibility features. For...
Importance Although the cognitive components of behavioral therapy for overactive bladder (OAB) are widely recognized, there is a lack studies evaluating effectiveness multicomponent interventions that include as treatment OAB. Objective To examine efficacy intervention in improving health-related quality life (HRQOL) women with moderate to severe Design, Setting, and Participants This multicenter, open-label, randomized clinical trial was conducted Japan among aged 20 80 years who had were...
Thioredoxin-interacting protein (TXNIP), which has a tumor-suppressive function, is underexpressed in some human cancers. The function of TXNIP vivo carcinogenesis not fully understood. Here, we show to be downregulated bladder cancer according grade and stage also that loss expression facilitates using mouse model. N -butyl- -(4-hydroxybutyl) nitrosamine (BBN)-induced was found 100% Txnip knockout (KO) mice at week 8 0.025% BBN administration but only 22% wild-type (WT) the same point....
Objectives To evaluate and compare the efficacy of sequential treatment with abiraterone followed by enzalutamide or vice versa for castration‐resistant prostate cancer. Methods We retrospectively evaluated data on 198 consecutive chemotherapy‐naïve patients who had received both cancer at Kyoto University Hospital (including satellite hospitals) Johns Hopkins Cancer Center. Prostate‐specific antigen progression‐free survival overall in treated ‐to‐ versus without intervening therapies were...
Since the standard gemcitabine and cisplatin (GC) chemotherapy for advanced bladder cancer yields limited therapeutic effect due to chemoresistance, it is a clinical challenge enhance sensitivity GC.We performed high-throughput screening by using library of known chemicals repositionable drugs. A total 2098 compounds were administered alone or with GC human cells, that enhanced effects screened.Disulfiram (DSF), an anti-alcoholism drug, was identified as candidate showing synergistic but not...
Significance Statement Ectopic lymphoid structures called tertiary tissues (TLTs) develop in several kidney diseases and are associated with poor renal prognosis. However, the mechanisms underlying TLT expansion their effect on regeneration remain unclear. The authors report that single-nucleus RNA sequencing validation experiments demonstrate TLTs potentially amplify inflammation aged injured kidneys. Lymphocytes within promote proinflammatory phenotypes of surrounding proximal tubules...