A5064270351- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Epigenetics and DNA Methylation
- Land Use and Ecosystem Services
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vietnamese History and Culture Studies
- Semiconductor materials and devices
- Research on Leishmaniasis Studies
- Molecular Biology Techniques and Applications
- Urban and spatial planning
- Rural development and sustainability
- Conservation, Biodiversity, and Resource Management
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Economic Growth and Fiscal Policies
- Urbanization and City Planning
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- RNA modifications and cancer
- Radiopharmaceutical Chemistry and Applications
- Physics of Superconductivity and Magnetism
Kyoto University
2011-2025
Dana-Farber Cancer Institute
2022-2024
Fujifilm (Japan)
2024
Cornell University
2024
Boston University
2024
Harvard University
2023
Kyoto University Hospital
2022
Center for Southeast Asian Studies
2021
Parks Victoria
2020
DMG Mori (Japan)
2018
Abstract A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic DNA. Cancer cell...
Rice is one of the important agricultural products in Indonesia. The production has been fully supported by infrastructure including research and development as well government regulations pricing. Its vulnerability to climate change requires adaptation strategies on irrigation, biotechnology selection alternative crops. primary goal this paper was evaluate historical perspective dynamics rice production, technologies particularly seed inventions, labour farming consumption from 1961 2009...
Castration-resistant prostate cancer (CRPC) is a heterogeneous disease associated with phenotypic subtypes that drive therapy response and outcome differences. Histologic transformation to castration-resistant neuroendocrine (CRPC-NE) distinct epigenetic alterations, including changes in DNA methylation. The current diagnosis of CRPC-NE challenging relies on metastatic biopsy. We developed targeted methylation assay detect using plasma cell-free (cfDNA). quantifies tumor content provides...
Notch signaling can have either an oncogenic or tumor-suppressive function in cancer depending on the type and cellular context. While be early prostate cancer, we identified significant downregulation of pathway during progression from adenocarcinoma to neuroendocrine (NE) where it functions as a tumor suppressor. Activation NE Rb1/Trp53-deficient models led phenotypic conversion toward more indolent, non-NE state with glandular features expression luminal lineage markers. This was...
Abstract The phenomena of land use/ change were evaluated by using a remote sensing approach in case study Yogyakarta, Indonesia. index changes, which was calculated the superimposition images 1972, 1984, and use maps 1990, introduced to analyse pattern area. results demonstrated that area paddy coverage open/ settlement. annual growth ratios new settlements absorb coverage, mixed vegetation, 16 per cent, 20 64 cent respectively. larger percentage higher tendency for settlement land, land....
Abstract The therapeutic landscape of castration-resistant prostate cancer (CRPC) has rapidly expanded. There is a need to develop noninvasive biomarkers guide treatment. We established highly sensitive method for analyzing androgen receptor gene ( AR ) copy numbers (CN) and mutations in plasma circulating cell-free DNA (cfDNA) evaluated the statuses patients with CRPC. amplification was detectable VCaP cell line amplified) genomic (gDNA) diluted 1.0% by digital PCR (dPCR). mutation were...
Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine (NEPC). methyltransferases (DNMTs) are highly expressed, global is dysregulated in NEPC. We identified that deletion DNMT genes decreases expression markers substantially reduced NEPC tumor development metastasis vivo. Decitabine, pan-DNMT inhibitor, attenuated growth patient–derived xenograft models, well retinoblastoma gene ( RB1 )–deficient...
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and emerging therapeutic target that overexpressed in most castration-resistant prostate cancers implicated as driver disease progression resistance to hormonal therapies. Here we define the lineage-specific action differential activity EZH2 both adenocarcinoma neuroendocrine cancer (NEPC) subtypes advanced better understand role modulating differentiation, lineage plasticity, identify mediators response inhibitor therapy....
Abstract To report clinical outcomes following highly hypofractionated biaxially rotational dynamic radiation therapy (BROAD‐RT), a unique method that facilitates non‐coplanar volumetric‐modulated arc (VMAT) without the need to rotate couch or reposition patient, for high‐risk prostate cancer (PCa) with simultaneous integrated boost (SIB) intra‐prostatic dominant lesions (IPDLs), we performed single‐center prospective pilot study. In this study, patients PCa according D'Amico classification...
In the present study, reliability and construct validity of Japanese version Chalder Fatigue Scale was evaluated as a measure severity fatigue among young students in Japan. A healthy group comprised 27 Grade 6 primary school 28 1 junior high students. The severely fatigued were hospital outpatients with childhood chronic syndrome (n = 21). Principal components analysis varimax rotation identified 4 factors which accounted for 63.2% total variance, original English version. Internal...
Abstract Purpose: Although cell-free DNA (cfDNA) testing is expected to drive cancer precision medicine, little known about the significance of detecting low-frequency variants in circulating tumor (ctDNA) castration-resistant prostate (CRPC). We aimed identify genomic profile including ctDNA from patients with CRPC and investigate clinical utility variant allele frequency (VAF) below 1%. Experimental Design: This prospective, multicenter cohort study enrolled eligible for treatment...
The aim of this study was to investigate cognitive functions such as allocation and information processing in patients with childhood type chronic fatigue syndrome (CCFS) using event-related potentials. A total 190 healthy children controls 414 CCFS participated study. Both had (i) potentials (including P300, P100, N150 P200 measurements); (ii) component analysis electrocardiographic R-R interval evaluate autonomic function; (iii) KANA-Pick-out test frontal lobe function. cutoff threshold...
Abstract The prevalence of neuroendocrine prostate cancer (NEPC) arising from adenocarcinoma (AC) upon potent androgen receptor (AR) pathway inhibition is increasing. Deeper understanding NEPC biology and development novel therapeutic agents are needed. However, research hindered by the paucity models, especially cell lines developed patients. We established a line, KUCaP13, tissue patient initially diagnosed with AC which later recurred as NEPC. line has been maintained permanently in vitro...
Abstract The therapeutic landscape of metastatic clear cell renal carcinoma (ccRCC) has rapidly expanded, and there is an urgent need to develop noninvasive biomarkers that can select optimal therapy or evaluate the response in real time. To clinical utility circulating tumor DNA (ctDNA) analysis ccRCC, we established a highly sensitive assay detect mutations von Hippel‐Lindau gene ( VHL ) using combination digital PCR multiplex PCR–based targeted sequencing. unique could with variant allele...
Abstract Early diagnosis of urological diseases is often difficult due to the lack specific biomarkers. More powerful and less invasive biomarkers that can be used simultaneously identify could improve patient outcomes. The aim this study was evaluate a disease‐specific scoring system established with machine learning (ML) approach using Ig N ‐glycan signatures. Immunoglobulin signatures were analyzed by capillary electrophoresis from 1312 serum subjects hormone‐sensitive prostate cancer ( n...