A5073004150- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Research on Leishmaniasis Studies
- Dermatology and Skin Diseases
- Histone Deacetylase Inhibitors Research
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Cancer therapeutics and mechanisms
- Cancer Mechanisms and Therapy
- Mycobacterium research and diagnosis
- FOXO transcription factor regulation
Zhaoqing University
2024
Henan Cancer Hospital
2024
Zhengzhou University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Gilead Sciences (United States)
2024
Shanghai Traditional Chinese Medicine Hospital
2024
Abstract A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic DNA. Cancer cell...
<div>Abstract<p>A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic...
Abstract Allergic rhinitis (AR) is a prevalent upper airway chronic inflammatory disease in children worldwide. The role of bioactive lipids the regulation AR has been recognized, but underlying serum lipidomic basis its pathology remains unclear. We utilized ultra‐performance liquid chromatography (UPLC)‐Q‐Exactive Orbitrap/mass spectrometry (MS) to investigate profiles with AR. analysis identified 42 that were differentially expressed ( p < 0.05, fold change > 2) between n = 75) and...
Cervical cancer (CC) is a malignant tumor with high incidence in women. It urgent to develop new diagnostic and predictive markers of CC improve the prognosis CC. Programmed cell death (PCD) cells has been proven play an essential role occurrence development tumors. From perspective bioinformatics, we discussed 12 PCD-related genes radiation-sensitive group radiation-resistant establishes risk model accordingly. At first, identified two hub related prognosis: PRKAA2 MLLT11. There was...
In cervical cancer (CC), the efficacy of chemotherapy is often hindered by development paclitaxel (PTX) resistance, even in patients who initially responded to chemotherapy.However, mechanisms underlying PTX resistance CC remain unclear.In this study, we uncover a unique role played CENPU (centromeric protein U, also known as PBIP1/KLIP1/CENP-50/MLF1IP) association with cells.First, established paclitaxel-resistant cell lines from Hela and SiHa cells (designated Hela/PTX SiHa/PTX) confirmed...
<p>Supplementary figureS2 shows the figures related to Figure 2.</p>
<p>Supplementary figureS1 shows the figures related to Figure 1.</p>
<p>Supplementary figureS3 shows the figures related to Figure 3.</p>
<p>Supplementary figureS4 shows the figures related to Figure 4.</p>
<p>Supplementary figureS4 shows the figures related to Figure 4.</p>
<div>Abstract<p>A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic...
<p>Supplementary figureS2 shows the figures related to Figure 2.</p>
<p>Supplementary figureS3 shows the figures related to Figure 3.</p>
<p>Supplementary figureS1 shows the figures related to Figure 1.</p>