A5009674198- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Medical Research and Treatments
- Medicinal Plant Pharmacodynamics Research
- Natural product bioactivities and synthesis
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Healthcare and Venom Research
- Viral Infections and Immunology Research
- Pneumonia and Respiratory Infections
- interferon and immune responses
- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
- Sphingolipid Metabolism and Signaling
- Chromatography in Natural Products
- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
- Food Quality and Safety Studies
Nanjing University of Chinese Medicine
2016-2025
Guangxi University of Chinese Medicine
2024
Nanjing University
2006-2021
Jiangsu Province Hospital
2021
Nanjing Traditional Chinese Medicine Hospital
2013-2021
Shougang (China)
2018
Nanjing Library
2014-2015
Nanjing Normal University
2012
Wan Fang Hospital
2011
Guangdong Provincial Hospital of Traditional Chinese Medicine
2011
Rhein is one of active anthraquinone components in traditional Chinese herbal medicine Rheum palmatum L., possessing anti-inflammatory, antioxidant, antitumor, antiviral, and hepatoprotective activities. Human respiratory syncytial virus (RSV), a common virus, able to result pneumonia bronchitis, which usually can be seen infants. However, so far the effects on RSV-induced are still unknown. As NLRP3 inflammasome activated excessively, it lead inflammatory response tissue injury most viral...
Resveratrol disrupts the early stages of RSV infection by engaging with HSPGs, thus impeding binding viral receptors. Resveratrol's affinity appears to be predominantly directed towards negatively charged sites on HSPGs.
Idiopathic central precocious puberty (ICPP) is an endocrine disorder increasingly observed in children, commonly treated with gonadotropin-releasing hormone agonists (GnRHa). However, the serum lipid profiles girls ICPP and potential regulatory effects of GnRHa metabolism remain unclear. This research analyzed lipidomic samples from younger than 10 years age, including 37 patients ICPP, 32 GnRHa, 30 age-matched healthy controls. Using UHPLC-Q-Exactive Orbitrap/MS, we identified a total 898...
In the present study, rationality for antiviral effect (H1N1 virus) of Flos Lonicerae Japonicae (FLJ, named JinYinHua)-Fructus forsythiae (FF, LianQiao) herb couple preparations improved by chito-oligosaccharide (COS) was investigated. We found that improvement activity four attributed to enhancement bioavailability FLJ-FF in vivo, and caffeic acid derivatives are most important type components activity. The anti-Influenza virus activity-half maximal inhibitory concentration (IC50), not area...
ABSTRACT Background and objective Asthma is a global problem complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma provided insights into asthmatic pathophysiology. Methods Children (aged 6–11 years) meeting criteria healthy control ( n = 29), uncontrolled 37) or controlled 43) were enrolled. Gas chromatography–mass spectrometry was performed on urine samples of patients explore different types metabolite profile in...
Astragaloside IV (AST) is the main active constituent of Radix Astragali, a Chinese herb traditionally used to prevent asthma attack from chronic patients. Its efficacy and action mechanisms in prevention remain nonetheless be further explored. In this study, was induced exposing ovalbumin (OVA) sensitized mice repeated OVA challenges twice every two weeks for 12 weeks. Mice were treated with AST 4 just after final challenge. murine model asthma, airway dysfunction remodeling remained severe...
Intestinal absorptions of phenolic acids as well those in<italic>Flos Lonicerae Japonicae</italic>were all mainly restricted by TJs.
Qingxuan Zhike granules (QXZKG), a traditional Chinese patent medication, has shown therapeutic potential against acute lung injury (ALI). However, the precise mechanism underlying its lung-protective effects requires further investigation. In this study, integrated network pharmacology, molecular docking, and lipidomics were used to elucidate QXZKG's regulatory effect on lipid metabolism in lipopolysaccharide-induced ALI. Animal experiments conducted substantiate efficacy of QXZKG reducing...
Abstract Allergic rhinitis (AR) is one of the most common allergic diseases in children and it can lead to physical mental health problems. Traditional Chinese medicine (TCM) plays an important role understanding phenotypes treatment AR. However, there are currently no normative clinical practice guidelines (CPGs) for AR children. The study aimed develop evidence‐based CPG with TCM. Systematic literature research, expert questionnaire, evaluation after three rounds surveys were adopted form...
Background: Respiratory syncytial virus (RSV) can cause varying degrees of lung inflammation in children. Qingfei Oral Liquid (QF) is effective treating childhood RSV-induced (RSV-LI) clinics, but its pharmacological profiles and mechanisms remain unclear. Methods: This study combined network Pharmacology, lipidomics, pharmacodynamics, pathway validation to evaluate the therapeutic QF. Using Cytoscape (v3.8.2) enrichment analyses from Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology...
Platycodi radix, the dried root of Platycodon grandiflorum A. DC, has been widely used as food and herb medicine for treating cough, cold other respiratory ailments, platycodin D (PD) is one most important compounds in Radix.The purpose this study was to compare pharmacokinetic characteristics, intestinal absorption microbial metabolism PD monomer with that radix extract (PRE).In study, concentrations rat plasma were determined by ultra-performance liquid chromatography-tandem mass...