A5101497640- Traditional Chinese Medicine Analysis
- Natural Compounds in Disease Treatment
- Flavonoids in Medical Research
- Berberine and alkaloids research
- Membrane Separation Technologies
- Membrane-based Ion Separation Techniques
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Analytical Chemistry and Chromatography
- Sphingolipid Metabolism and Signaling
- Traditional Chinese Medicine Studies
- Tryptophan and brain disorders
- Inhalation and Respiratory Drug Delivery
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Nanopore and Nanochannel Transport Studies
- Extraction and Separation Processes
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Electrohydrodynamics and Fluid Dynamics
- Metabolomics and Mass Spectrometry Studies
- Advanced Drug Delivery Systems
- Alkaloids: synthesis and pharmacology
- Medicinal Plants and Neuroprotection
Nanjing University of Chinese Medicine
2016-2025
Hubei University of Medicine
2024
Taihe Hospital
2024
Nanjing University
2010-2022
Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed Tmax Tripterygium wilfordii (TW), sovereign medicine Qing-Luo Tong-Bi decoction, which hinted absorption process might be involved in decreasing toxicity liver kidney.The triptolide, triptonide, wilforlide tripterine from monomer, TW, TW-PN, TW-Caulis Sinomenii (TW-CS) were analyzed duodenum, jejunum, ileum colon rat via single-pass intestinal perfusion model. An UPLC-MS/MS analysis method...
Berberine, a primary pharmacological active constitute of Coptidis Rhizoma, could inhibit neuronal apoptosis in cerebral ischemia. Here, we aimed to investigate whether and how HIF-1 is implicated the anti-apoptosis effect berberine on neurons under hypoxia/ischemia. Viability PC12 cells treated with prior or following CoCl2-induced hypoxia was evaluated. Annexin V-PI staining employed analyse cell ratio. HIF-1α apoptosis-associated molecules were detected via Western blotting. TUNEL...
Triptolide (TP), an active constituent of Tripterygium wilfordii, possesses numerous pharmacological activities. However, its effects on cytochrome P450 enzymes (CYP450s) in rats remain unexplored. In this study, the triptolide six main CYP450 isoforms (1A2, 2C9, 2C19, 2D6, 2E1, and 3A) were investigated both vivo vitro. We monitored body weight, survival proportions, liver index, changes pathology, biochemical index upon TP administration, vivo. Using a cocktail probe isoform-specific...
Pulmonary fibrosis (PF) is a kind of interstitial lung disease with the features progressive and often fatal dyspnea. Tetrandrine (TET) major active constituent Chinese herbal Stephania tetrandra S. Moore, which has already applied clinically to treat rheumatism, cancer, silicosis. In this work, tetrandrine-hydroxypropyl-β-cyclodextrin inclusion compound (TET-HP-β-CD) was developed for treatment pulmonary via inhalation administration. TET-HP-β-CD prepared by freeze-drying method identified...
Traditional Chinese medicine (TCM) is an important part of culture and the pharmaceutical industry. The adoption stricter requirements for quality medicines has resulted in loss conformity some traditional techniques used to prepare TCMs modern methods. TCM industry begun seek out novel methods improve product increase economic efficiency. Membrane technology efficient, energy saving, environmentally friendly. It widely food processing, desalination, wastewater treatment, medical also been...
Neuroinflammation is one of the major pathogeneses in Alzheimer's disease (AD) and mainly involves abnormal inflammatory activation microglia by multiple pathological stimuli. The treatment AD remains a challenge due to multifactorial characterization inefficient ability therapeutic drugs permeate through blood‒brain barrier (BBB). Accordingly, drug combination carrier delivery have become important tools for diseases, especially AD.Inflammatory cytokine levels microglia, including NO,...
Abnormal sphingolipid metabolism is closely related to the occurrence and development of Alzheimer's disease (AD). With heat-clearing detoxifying effects, Huanglian Jiedu decoction (HLJDD) has been used treat dementia improve learning memory impairments.To study therapeutic effect HLJDD on AD as it relates metabolism.The level sphingolipids in brains APP/PS1 mice supernatant β-amyloid (Aβ)25-35-induced BV2 microglia was detected by HPLC-QTOF-MS HPLC-QTRAP-MS techniques, respectively. The...
Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was explore the unclear protective mechanism catalpol against triptolide. detoxification effect on triptolide investigated in HepaRG cell line. effects were assessed by measuring viability, autophagy, and apoptosis, as well endoplasmic reticulum stress protein mRNA expression levels. We found that 5-20 µg/L treatments increased levels alanine aminotransferase (ALT),...