A5054136566- Natural Compounds in Disease Treatment
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Palliative Care and End-of-Life Issues
- Traditional Chinese Medicine Studies
- Cytomegalovirus and herpesvirus research
- Angiogenesis and VEGF in Cancer
- Pharmacological Effects of Natural Compounds
- Patient Dignity and Privacy
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Natural product bioactivities and synthesis
- Spondyloarthritis Studies and Treatments
- T-cell and B-cell Immunology
- Flavonoids in Medical Research
- Cholesterol and Lipid Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Caveolin-1 and cellular processes
- Healthcare and Venom Research
- Ethics in medical practice
- Genomics, phytochemicals, and oxidative stress
- Immune cells in cancer
- Pain Management and Opioid Use
- Cancer survivorship and care
- Complementary and Alternative Medicine Studies
Nanjing University of Chinese Medicine
2019-2022
Zhongnan Hospital of Wuhan University
2017-2022
Wuhan University
2017-2022
City Of Hope National Medical Center
2022
Western Sydney University
2021
Beijing Fengtai Hospital
2014
Juntendo University
2012
Wuhan Blood Center
2011
University of California, San Francisco
2005
To fully assess the role of VEGF-A in tumor angiogenesis, antibodies that can block all sources vascular endothelial growth factor (VEGF) are desired. Selectively targeting tumor-derived VEGF overlooks contribution host stromal VEGF. Other strategies, such as receptors directly or using receptor decoys, result inhibiting not only but also homologues (e.g. placental factor, VEGF-B, and VEGF-C), which may play a angiogenesis. Here we report identification novel anti-VEGF antibodies, B20 G6,...
Vascular endothelial growth factor-A (VEGF) is an important regulator of vascular permeability. In preclinical studies, VEGF induces fenestrations in pre-existing and neo-vasculature, while inhibition leads to a reduction fenestrations. Recently, regression response has been shown correlate with the presence Plasmalemmal vesicle-associated protein (PLVAP) believed be component diaphragmed fenestrations, but direct relationship signalling not established. The aim this study was characterize...
To evaluate the relationship between pain and quality of life (QoL) in patients newly admitted to Wuhan Hospice Center, China. A total 1,634 were analyzed this retrospective study. Numerical Rating Scale Chinese-QoL instrument used assess score QoL, respectively. Most experienced moderate severe pain, which significantly impaired QoL. The was correlated with appetite, mood, sleep, fatigue, intensity, daily activity, side effect, general appearance, support from family. But there no...
Triptolide (TP), as the main component of Tripterygium Wilfordii (TW), can induce obvious liver injury when exerting therapeutic effect. However, in our previous study, Catalpol (CAT), active ingredient Rehmannia Glutinosa (RG), was shown to increase drug clearance rate TP and attenuate TP-induced hepatotoxicity. Thus present study aims address roles phase I II metabolic enzymes nuclear receptors detoxification process TP, analyze mechanism CAT reducing For this purpose, SD rats human cell...
Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was explore the unclear protective mechanism catalpol against triptolide. detoxification effect on triptolide investigated in HepaRG cell line. effects were assessed by measuring viability, autophagy, and apoptosis, as well endoplasmic reticulum stress protein mRNA expression levels. We found that 5-20 µg/L treatments increased levels alanine aminotransferase (ALT),...
AIM:To elucidate the role of neuropilin-1 (Nrp-1) and semaphorin 3A (Sema3A) in sinusoidal remodeling during liver regeneration rats. METHODS:Male Wistar/ST rats at 7 wk age, weighing about 200 g, were used for all animal experiments.In vivo , 24, 48, 72, 96, 144 192 h after twothirds partial hepatectomy (PHx), remnant livers removed.Liver tissues immunohistochemically stained Nrp-1, Sema3A SE-1, a endothelial cell (SEC) marker.Total RNA tissue was extracted reversely transcribed into...
BACKGROUND:The hepatotoxicity of Tripterygium wilfordii Hook. f. (TWHF) limits its clinic utilization. Qingluo Tongbi formula (QTF) was formulated based on a basic Chinese medicine theory. Previous studies have confirmed the safety and efficacy QTF in treating rheumatoid arthritis. Therefore, we considered that TWHF could be detoxified reasonable compatibility with QTF. We investigated detoxicity mechanism reducing liver toxicity TWHF. MATERIAL AND METHODS:We used network pharmacology to...
Abstract Background: The PI3K-AKT-mTOR signaling pathway is deregulated in a wide variety of cancers. GDC-0980 potent, selective, oral inhibitor class I PI3K and mTOR kinase demonstrating broad activity xenograft cancer models (breast, ovarian, lung, prostate). Methods: A Phase dose escalation study using 3+3 design has been initiated patients (pts) with advanced solid tumors or non-Hodgkin's lymphoma. administered QW. objectives are to determine the dose-limiting toxicities (DLTs) maximum...
The Heart to Card Game improves psychological health outcomes in hospitalized patients with advanced cancer, but effectiveness studies for at home are rare. This randomized controlled study was conducted determine the of on cancer receiving home-based palliative care. Sixty-six participants were randomly assigned intervention group (n = 34) and control 32). quality life, dignity, distress considered as outcomes, which assessed pre-intervention six weeks after intervention. There a...
To evaluate the significance of T-cell antigen receptor (TCR) gene rearrangement among patients with acquired pure red cell aplastic anemia (A-PRCA).For 16 A-PRCA, an immunosuppressive regimen based on cyclosporin A (CsA) was applied. Rearrangement TCR detected by PCR, and T lymphocyte subsets in peripheral blood specimens flow cytometry.Five had presented clonal were positive for both γ δ. The 13 have returned to normal treatment, which included 3 cases bone marrow returning normal. In 7...
Objective To detect and analyse acquired pure red cell aplasia (PRCA) T lymphocyte subsets distribution to assess its condition cyclosporine immune function of lymphocytes subsets. Methods Flow cytometry was applicated peripheral blood PRCA patients before after 3 months treatment with cyclosporine-based immunosuppressive regimen normal controls. Results Among 22 patients, 17 cases returning (three bone marrow normal), the total effective rate 95.5 % (3 cure, 14 remission, 4...
Objective To assess the effectiveness of using Clip closure defect after endoscopic mucosal resection(EMR), submucosal dissection(ESD)and others to reduce rate delayed postoperative bleeding and accelerate wound healing. Methods Papers published before October 2017 in PubMed、EMBase Cochrance library about EMR, ESD were obtained by computer retrieval.Meta-analysis for each outcome included studies that identified inclusion criteria exclusion was conducted software Review Manager...
Objective To investigate the expression levels of CD4+ CD25+ FOXP3+ Treg cells and interleukin(IL)-10 in serum patients with myelodysplastic syndrome (MDS) - refractory anemia (RA) hematopenia multilineage dysplasia (RCMD), to evaluate effect cyclosporine on MDS patients. Methods From January 2016 2018, 25 MDS-RA RCMD 13 healthy controls were selected from people′s Hospital Xinjiang Uygur Autonomous Region for retrospective analysis.The CD4 + CD25 Foxp3 IL-10 peripheral blood samples...
Objectives: Tripterygium glycosides (TG) is the most widely used extract from wilfordii Hook F (TwHF). Because of its good anti-inflammatory and immunosuppressive functions in treatment rheumatoid arthritis (RA), it considered as a traditional Chinese medicine DMARD. The objective this study was to further explore efficacy safety combined use TG based on conventional DMARD monotherapy, well main characteristics, possible mechanisms influencing factors efficacy, provide guidance for clinical...