A5102015137- Natural Compounds in Disease Treatment
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
- Chemotherapy-induced organ toxicity mitigation
- Histone Deacetylase Inhibitors Research
- Bone Metabolism and Diseases
- Plant Virus Research Studies
- Pharmacological Effects and Toxicity Studies
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- Traditional Chinese Medicine Analysis
- Plant and Fungal Interactions Research
- Medicinal Plant Pharmacodynamics Research
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Medical Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Plant pathogens and resistance mechanisms
- Respiratory and Cough-Related Research
- Occupational Health and Safety Research
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
Nanjing University of Chinese Medicine
2013-2024
Nanjing University
2004-2011
Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed Tmax Tripterygium wilfordii (TW), sovereign medicine Qing-Luo Tong-Bi decoction, which hinted absorption process might be involved in decreasing toxicity liver kidney.The triptolide, triptonide, wilforlide tripterine from monomer, TW, TW-PN, TW-Caulis Sinomenii (TW-CS) were analyzed duodenum, jejunum, ileum colon rat via single-pass intestinal perfusion model. An UPLC-MS/MS analysis method...
Triptolide (TP), an active constituent of Tripterygium wilfordii, possesses numerous pharmacological activities. However, its effects on cytochrome P450 enzymes (CYP450s) in rats remain unexplored. In this study, the triptolide six main CYP450 isoforms (1A2, 2C9, 2C19, 2D6, 2E1, and 3A) were investigated both vivo vitro. We monitored body weight, survival proportions, liver index, changes pathology, biochemical index upon TP administration, vivo. Using a cocktail probe isoform-specific...
Triptolide (TP), known for its effectiveness in treating various rheumatoid diseases, is also associated with significant hepatotoxicity risks. This study explored Catalpol (CAT), an iridoid glycoside antioxidative and anti-inflammatory effects, as a potential defense against TP-induced liver damage.
Triptolide (TP), as the main component of Tripterygium Wilfordii (TW), can induce obvious liver injury when exerting therapeutic effect. However, in our previous study, Catalpol (CAT), active ingredient Rehmannia Glutinosa (RG), was shown to increase drug clearance rate TP and attenuate TP-induced hepatotoxicity. Thus present study aims address roles phase I II metabolic enzymes nuclear receptors detoxification process TP, analyze mechanism CAT reducing For this purpose, SD rats human cell...
Tripterygium wilfordii (TW) and the representative active component triptolide show positive therapeutic effect on autoimmune disorders simultaneously ineluctable hepatotoxicity nephrotoxicity. Combinational application of Panax notoginseng (PN) Rehmannia glutinosa (RG) weakens toxicity TW according clinical traditional Chinese medicine. This article was aimed at mechanism decreasing by combinational PN RG. Biochemical pathohistological analysis were utilized to assess liver kidney in rats...
Osteoclast, which mediates overactive bone resorption, is one of the key factors for destruction in rheumatoid arthritis (RA). Existing studies have shown that abnormal miR-143-3p expression was observed both RA patients and animals, can participate osteoclast differentiation, mitogen-activated protein kinase (MAPK) signaling pathway closely related to differentiation. The primary objective current study determine role progression differentiation its relationship with MAPK pathways. results...
BACKGROUND:The hepatotoxicity of Tripterygium wilfordii Hook. f. (TWHF) limits its clinic utilization. Qingluo Tongbi formula (QTF) was formulated based on a basic Chinese medicine theory. Previous studies have confirmed the safety and efficacy QTF in treating rheumatoid arthritis. Therefore, we considered that TWHF could be detoxified reasonable compatibility with QTF. We investigated detoxicity mechanism reducing liver toxicity TWHF. MATERIAL AND METHODS:We used network pharmacology to...
Tripterygium wilfordii Hook. f. induced-hepatotoxicity was the main limitation for its usage in clinic. Qingluo Tongbi formulation showed obvious attenuation hepatotoxicity clinic and fundamental research vivo. To explore potential mechanism of attenuation, we conducted a study on plasma metabolomic profiles T. rats by sensitive gas chromatography-mass spectrometry (GC-MS/MS) method. In samples, total 72 compounds were analyzed EI source MS, successfully identified matching NIST database....
Tripterygium wilfordii (TW) is widely employed to treat rheumatoid arthritis and autoimmune disorders clinically, which, however, accompany with disturbing hepatotoxicity nephrotoxicity. The previous research showed that Panax notoginseng (PN) compatibly significantly reduces the TW-induced hepatotoxicity.To explore underlying mechanism, present study was designed reveal influence of PN on intestinal absorption process TW-derived active components in rat.An situ single-pass perfusion...
Objective: To investigate the cause of occupational exposure among 136 nurses in a tertiary infectious disease hospital, and puts forward prevention strategy. Methods: A total exposed to between 2014 2016 were included study. Analysis was conducted from years work nurses, routes, pathogens. Results: The suffer highest risk exposures (73.91%) .Nurses working for less than 5 interns are most likely (45.59% 35.29% respectively) . Occupational mainly caused by needle injuries, which infusion...