A5100729292- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Estrogen and related hormone effects
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
- Lung Cancer Treatments and Mutations
- Autoimmune Bullous Skin Diseases
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Inflammatory mediators and NSAID effects
- Eosinophilic Disorders and Syndromes
- Cancer-related gene regulation
- Cutaneous lymphoproliferative disorders research
- Inflammatory Myopathies and Dermatomyositis
- Cell Adhesion Molecules Research
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Parathyroid Disorders and Treatments
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Huizhou Central People's Hospital
2023-2025
Jinzhou Medical University
2015-2024
Spice and Beverage Research Institute
2024
Ministry of Agriculture and Rural Affairs
2024
Chinese Academy of Tropical Agricultural Sciences
2024
Huazhong Agricultural University
2024
Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases (CVDs) in later life. However, the evidence on effects CVD is still inconsistent, especially East Asians, whom frequency duration breastfeeding significantly differ from those West.In 2004-2008, nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 79 years 10 diverse regions across China. During 8 follow-up, 16 671 incident cases...
There is substantial heterogeneity among the phenotypes of patients with anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis (DM), hindering disease assessment and management. This study aimed to identify distinct phenotype groups in anti-MDA5+ DM determine utility these predicting patient outcomes.A total 265 were retrospectively enrolled study. An unsupervised hierarchical cluster analysis was performed characterize different phenotypes.Patients...
Recent data have revealed that oxidative products and inflammatory mediators are increased in the insulin‐resistant states of obesity type 2 diabetes mellitus (T2DM). Obese patients with impaired glucose tolerance (IGT) at high risk for developing T2DM incidence dyslipidemia. α‐Lipoic acid (ALA) is a potent antioxidant insulin sensitizing activity. However, it not clear whether ALA effective on lipid parameters humans. This study has investigated 22 obese subjects IGT (obese‐IGT), 13 whom...
Objective Interstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in patients with dermatomyositis (DM) who are positive for antimelanoma differentiation–associated gene 5 antibody (anti-MDA5+). We conducted this study investigate the association of anti-Ro52 antibodies clinical characteristics prognosis anti-MDA5+ DM. Methods assessed cohort 246 To calculate hazard ratios 95% CIs rapidly progressive ILD (RP-ILD) death while...
Abstract Objectives Anti-melanoma differentiation-associated gene 5 positive (anti-MDA5+) DM has a close relationship with rapidly progressive interstitial lung disease (RPILD) and is associated high mortality. However, data regarding the time-dependent risk of RPILD deaths during progression are limited. We conducted this study to investigate whether death were or not in anti-MDA5+ DM. Methods assessed cohort 272 patients The clinical characteristics collected, COX regression was used...
Background The prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5 + DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) these patients’ leading cause death. We sought to develop prediction models for RP-ILD risk in anti-MDA5 DM patients. Methods Patients with were enrolled two cohorts: 170 patients from the southern region Jiangsu province (discovery cohort) 85 northern (validation cohort). Cox proportional...
1,25(OH)(2)D(3) antiproliferative properties are widely known. However, the molecular bases of these only partially elucidated. Since effectively arrests growth in many tumors and hyperplastic tissues whose is driven by co-expression EGFR its ligand TGF-alpha, it was hypothesized that could affect TGF-alpha/EGFR-autocrine loop. This study examined regulation EGFR-growth signals, using human epidermoid A431 cells, which overexpression TGF-alpha constitute major autocrine mitogenic signal....
Extracellular signal-regulated kinase (ERK) belongs to the mitogen-activated protein kinases (MAPK) superfamily. Aberrant upregulation and activation of ERK cascades may often lead tumor cell development. However, how is involved in progression yet be defined. In current study, we described that undergoes S-nitrosylation by nitric oxide (NO). inhibits its phosphorylation triggers apoptotic program as verified massive apoptosis fluorescence staining. The proapoptotic effect NO induced...
Background: Recent studies revealed that miR-424-5p regulates the malignant behavior of multiple cancer types. However, expression and function in laryngeal squamous cell carcinoma (LSCC) is unclear. Purpose: This study aimed to evaluate association level with clinical features LSCC investigate effect potential mechanism on progression. Methods: The paired adjacent normal margin (ANM) tissues from 106 patients were analyzed by quantitative PCR (qPCR), significance was analyzed. Target genes...
We previously reported the discovery, validation, and structure–activity relationships of a series piperidinyl ureas that potently inhibit DCN1–UBE2M interaction. demonstrated compound 7 inhibits both protein–protein interaction DCN1-mediated cullin neddylation in biochemical assays reduces levels steady-state squamous carcinoma cell line harboring DCN1 amplification. Although exhibits good solubility permeability, it is rapidly metabolized microsomal models (CLint = 170 mL/min/kg). This...
Abstract Background The phenomenon of codon usage bias is known to exist in many genomes and mainly determined by mutation selection. Codon analysis a suitable strategy for identifying the principal evolutionary driving forces different organisms. Sunflower ( Helianthus annuus L.) an annual crop that cultivated worldwide as ornamentals, food plants their valuable oil. WRKY family genes play central role diverse regulation multiple stress responses. Evolutionary H. can provide rich genetic...
Layout generation aims to synthesize realistic graphic scenes consisting of elements with different attributes in-cluding category, size, position, and between-element relation. It is a crucial task for reducing the burden on heavyduty design works formatted scenes, e.g., publications, documents, user interfaces (UIs). Diverse application scenarios impose big challenge in unifying various layout subtasks, including conditional unconditional generation. In this paper, we propose Diffusion...
Calcitriol, acting through vitamin D receptors (VDR) in the parathyroid, suppresses parathyroid hormone synthesis and cell proliferation. In secondary hyperparathyroidism (SH), VDR content is reduced as hyperplasia becomes more severe, limiting efficacy of calcitriol. a rat model SH, activation EGF receptor (EGFR) by TGF-alpha required for development hyperplasia, but relationship between EGFR unknown. With use same model, it was found that pharmacologic inhibition with erlotinib prevented...
Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant head and neck carcinoma. Exploring molecular indicators of behavior will enhance our knowledge this type cancer provide novel options for its prevention, diagnosis, treatment. MicroRNA might exert regulatory roles as oncogenes or anti-oncogenes. We studied expression miR-301a-3p in LSCC tissues lines conducted a functional analysis to confirm if functions an oncogene LSCC. found Smad4 be one potential target genes...