A5084599925- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Systemic Lupus Erythematosus Research
- Skin Diseases and Diabetes
- Atherosclerosis and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Regulation of Appetite and Obesity
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- Advanced Glycation End Products research
- Neurological Disorders and Treatments
- Neurological Complications and Syndromes
- Neurological Disease Mechanisms and Treatments
- ATP Synthase and ATPases Research
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Biochemical Analysis and Sensing Techniques
- Muscle Physiology and Disorders
- RNA regulation and disease
- Autoimmune and Inflammatory Disorders Research
- Advanced biosensing and bioanalysis techniques
- Cerebral Venous Sinus Thrombosis
- Mitochondrial Function and Pathology
Wuxi People's Hospital
2014-2025
Nanjing Medical University
2014-2025
Soochow University
2022
Northern Jiangsu People's Hospital
2022
Xuzhou Medical College
2022
Affiliated Hospital of Nantong University
2022
Changzhou No.2 People's Hospital
2022
Nantong University
2022
Jiangsu Province Hospital
2022
The First People's Hospital of Changzhou
2022
There is substantial heterogeneity among the phenotypes of patients with anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis (DM), hindering disease assessment and management. This study aimed to identify distinct phenotype groups in anti-MDA5+ DM determine utility these predicting patient outcomes.A total 265 were retrospectively enrolled study. An unsupervised hierarchical cluster analysis was performed characterize different phenotypes.Patients...
Objective Interstitial lung disease (ILD) is a common extramuscular complication contributing to significant morbidity and mortality in patients with dermatomyositis (DM) who are positive for antimelanoma differentiation–associated gene 5 antibody (anti-MDA5+). We conducted this study investigate the association of anti-Ro52 antibodies clinical characteristics prognosis anti-MDA5+ DM. Methods assessed cohort 246 To calculate hazard ratios 95% CIs rapidly progressive ILD (RP-ILD) death while...
Abstract Objectives Anti-melanoma differentiation-associated gene 5 positive (anti-MDA5+) DM has a close relationship with rapidly progressive interstitial lung disease (RPILD) and is associated high mortality. However, data regarding the time-dependent risk of RPILD deaths during progression are limited. We conducted this study to investigate whether death were or not in anti-MDA5+ DM. Methods assessed cohort 272 patients The clinical characteristics collected, COX regression was used...
Background The prognosis of anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5 + DM) is poor and heterogeneous. Rapidly progressive interstitial lung disease (RP-ILD) these patients’ leading cause death. We sought to develop prediction models for RP-ILD risk in anti-MDA5 DM patients. Methods Patients with were enrolled two cohorts: 170 patients from the southern region Jiangsu province (discovery cohort) 85 northern (validation cohort). Cox proportional...
The incidence and prevalence of systemic lupus erythematosus (SLE) have increased annually over the past decade. involvement myocardium is one main reasons for poor prognosis patients with SLE. Identifying myocardial in autoimmune diseases providing early targeted treatment can improve patient outcomes. aim this study to evaluate dysfunction SLE using 99m Tc-MIBI rest gated perfusion imaging (rGMPI) investigate factors associated dysfunction. 76 were prospectively enrolled 46 without or...
Objective The aim is to investigate the clinical characteristics of systemic lupus erythematosus with intracranial hypertension. Methods one case chronic persistent hypertension were analyzed, and related literature was reviewed by searching Medline Wanfang databases. Results Intracranial in SLE patients may occur at onset or during course disease. Our patient diagnosed IH 3 years after SLE. Headache papilledema most common symptoms hypertension, followed nausea vomiting, vision changes,...
Background A rapid and sensitive time‐resolved fluoroimmunoassay (TRFIA) based on the biotin–streptavidin amplification system was developed for determination of anticyclic citrullinated peptide (anti‐CCP). Methods Europium‐labeled streptavidin derivatives combined with europium anhydride diethylene triamine pentaacetic acid were used to label streptavidin, biotin coupled rabbit anti‐human IgG form a biotin–anti‐human bridge between streptavidin–europium anti‐CCP antibody in immunoassay. The...
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease mainly mediated by IgG autoantibody. While follicular helper T (Tfh) cells are crucial for supporting autoantibody generation in human SLE, underlying mechanisms Tfh cell mal-differentiation remain unclear.In total, 129 SLE patients and 37 healthy donors were recruited this study. Circulating leptin was determined ELISA from with individuals. CD4 isolated activated anti-CD3/CD28 beads under cytokine-unbiased conditions the...
<title>Abstract</title> Backgroud: The incidence and prevalence of systemic lupus erythematosus (SLE) have increased annually over the past decade. involvement myocardium is one main reasons for poor prognosis patients with SLE. Identifying myocardial in autoimmune diseases providing early targeted treatment can improve patient outcomes. Objectives aim this study to evaluate dysfunction SLE using <sup>99m</sup>Tc-MIBI rest gated perfusion imaging (rGMPI) investigate factors associated...
Objective To investigate the function of mitophagy in instructing T-cell differentiation patients with rheumatoid arthritis (RA).
Introduction To identify the clinical characteristics and risk factors for cutaneous ulcers in patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+ DM) combined rapidly progressive interstitial lung disease (RPILD). Material methods We conducted a retrospective cohort study on medical records of enrolled from Nanjing Medical University Myositis-associated ILD (NMMI). The ulcer-positive group were compared those ulcer-negative by...
In patients with systemic lupus erythematosus (SLE), myocardial involvement is the third leading course of death after nephropathy (LN) and infections. Previous autopsy studies have demonstrated a high incidence cardiovascular abnormalities in myocardium. However, typical symptoms are far much fewer than expected from post-mortem examinations.The current study aimed to evaluate technetium-99m-sestamibi (99mTc-MIBI) gated perfusion imaging (GMPI) characteristics without symptoms,...
To investigate the effects and their possible mechanisms of cell division cycle 42 (Cdc42) to neonatal rat myocardial cells subjected ischemia-repefusion. Neonatal cardiomyocytes were cultured then ischemia-reperfusion. Experimental groups 1. Control group; 2. Ischemia-repefusion group (I/R group); 3. Oligofectamine (Oli 4. antisense oligodeoxynucleotide (AS-ODN) (As 5. missense (MS-ODN) (Ms 6. SP600125 AS-ODN (SP600125/As 7. MS-ODN (SP600125/Ms group). The cardiacmyocyte apoptosis rate was...
Abstract Background Fever is a common symptom of Idiopathic inflammatory myopathies (IIM). However, the exact correlation between fever and prognosis IIM still unclear. This study aims to clarify if patients initiated with are associated poorer outcomes. Methods was single-center retrospective cohort study. Data were collected from 79 newly diagnosed, treatment-naive in Affiliated Wuxi People’s Hospital Nanjing Medical University (Wuxi, Jiangsu, China) November 2016 June 2020. According...
Objective To further understand the clinical characteristics of cardiac involvement in Behcet disease (BD). Methods Two cases BD with damage were reported and analyzed. And literatures from Medline database Weipu reviewed discussed. Results Two patients had aortic valve prolapse insufficiency. One patient mitral Valve stenosis was not found these two cases. Pathologically, valves showed fibrosis denaturation. Review literature that more frequently male. Cardiac abnormalities...
Objective To retrospectively analyze the clinical features of elderly-onset systemic lupus erythematosus (SLE). Methods A total 916 patients were enrolled in this retrospective study, and their data collected by same methods past ten years (1999-2009) fifteen hospitals Jiangsu Province. Patients divided into two groups based on age onset disease: control group elderly group. The relationships between features, immunology index disease activity analyzed different...
Abstract Background Fever is a common symptom of Idiopathic inflammatory myopathies (IIM). However, the exact correlation between fever and prognosis IIM still unclear. This study aims to clarify if patients initiated with are associated poorer outcomes. Methods was single-center retrospective cohort study. Data were collected from 79 newly diagnosed, treatment-naive patient s in Affiliated Wuxi People's Hospital Nanjing Medical University (Wuxi, Jiangsu, China) November 2016 June 2020....
<h3>Background</h3> B lymphocytes derived from patients with systemic lupus erythematosus (SLE) displayed abnormal activation and overexpression of auto-antibodies. It was reported that leptin elevated in the sera SLE mice, blockade also remarkably improved disease activity renal pathology mice. Therefore, our study is to explore whether regulates function cells. <h3>Objectives</h3> Our <h3>Methods</h3> The peripheral blood monocyte cells (PBMC) were isolated healthy controls Ficoll, then...
Objective To explore the clinical characteristics and prognostic indicators that classify patients with systemic lupus erythematosus (SLE) at risk of in-hospital mortality. Methods Medical records 1611 SLE admitted between 1999-2009 were collected from 26 centers across Jiangsu province, divided into two groups based on outcomes. The suspected factors poor outcomes selected then analyzed by chi-square test, independent-samples t Wilcoxon rank sum test Logistic...