A5101681513- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Respiratory viral infections research
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Analysis
- Pharmacogenetics and Drug Metabolism
- Tryptophan and brain disorders
- Mass Spectrometry Techniques and Applications
- Sphingolipid Metabolism and Signaling
- Plant-based Medicinal Research
- Neonatal Respiratory Health Research
- Analytical Chemistry and Chromatography
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Berberine and alkaloids research
- Peroxisome Proliferator-Activated Receptors
- Traditional Chinese Medicine Studies
- Immune cells in cancer
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Phytochemistry and Biological Activities
- Chromatography in Natural Products
Nanjing University of Chinese Medicine
2016-2025
58.com (China)
2024
Huaiyin Institute of Technology
2023-2024
Sun Yat-sen University
2022-2024
Hunan Normal University
2024
Second Affiliated Hospital of Jilin University
2023
China Geological Survey
2023
The University of Texas MD Anderson Cancer Center
2022
Bengbu Medical College
2022
Nanjing University
2022
Ginsenoside Rg3 (Rg3), a major active ingredient enriched in red ginseng, possesses well-confirmed immunoregulatory effects. Immune disturbance is common trigger and aggravating factor of depression. The aim this study was to explore the effects on lipopolysaccharide (LPS)-induced depression-like behavior mice involvement immune regulation. Pretreatment with (i.g., 20 40 mg/kg) effectively ameliorated LPS (i.p., 0.83 induced body weight loss, anorexia, immobility time both tail suspension...
Abstract Background The effectiveness of ginseng in preventing and treating various central nervous system (CNS) diseases has been widely confirmed. However, ginsenosides, the principal components ginseng, are characterized by poor accessibility to brain, this pharmacokinetic-pharmacological paradox remains poorly explained. Anti-inflammatory approaches becoming promising therapeutic strategies for depression other CNS diseases; however, previous studies have focused largely on...
The dopamine, serotonin, and kynurenine metabolic pathways play pivotal roles on brain function, their disturbances are closely related to various neurological diseases. Comprehensive measurements of these metabolites is thus essential for monitoring the global neurochemical responses pathological challenges or drug intervention. However, simultaneous measurement neurochemcial represents a great challenge. We developed herein an original feasible method using high-performance liquid...
Rhein is one of active anthraquinone components in traditional Chinese herbal medicine Rheum palmatum L., possessing anti-inflammatory, antioxidant, antitumor, antiviral, and hepatoprotective activities. Human respiratory syncytial virus (RSV), a common virus, able to result pneumonia bronchitis, which usually can be seen infants. However, so far the effects on RSV-induced are still unknown. As NLRP3 inflammasome activated excessively, it lead inflammatory response tissue injury most viral...
Triptolide (TP), an active constituent of Tripterygium wilfordii, possesses numerous pharmacological activities. However, its effects on cytochrome P450 enzymes (CYP450s) in rats remain unexplored. In this study, the triptolide six main CYP450 isoforms (1A2, 2C9, 2C19, 2D6, 2E1, and 3A) were investigated both vivo vitro. We monitored body weight, survival proportions, liver index, changes pathology, biochemical index upon TP administration, vivo. Using a cocktail probe isoform-specific...
ABSTRACT In this study, Balb/c mice were subjected to chronic unpredictable mild stress (CUMS) and treated with Zhi‐zi‐chi Decoction (ZZCD). Using a hippocampal lipidomics approach that combined ultra performance liquid chromatography (UPLC)‐Q‐Exactive Orbitrap MS multivariate statistical techniques targeted metabolic pathway analysis, we identified potential lipid metabolites pathways associated depression. Meanwhile, anti‐inflammatory analyses conducted in the hippocampus of mice. The...
The Zushima tablet (ZT) has been used for decades in the clinical treatment of rheumatoid arthritis (RA) China. However, its therapeutic mechanism is unclear. In this study, we aimed to explore distinctive metabolic patterns collagen-induced (CIA) rats and evaluate effects ZT on RA using untargeted serum fecal metabolomics approaches based gas chromatography coupled with mass spectrometry. Body weight, hind paw swelling, TNF-α IL-1β levels, scores, histopathological parameters were assessed....
Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting hospitalization. At present, the molecular-level interactions between RSV and its host underlying mechanisms of RSV-induced inflammation are poorly understood. Herein, we describe an untargeted high-resolution lipidomics platform based on UHPLC-Q-Exactive-MS to assess lipid alterations lung tissues plasma from...
Acute lung injury (ALI), an acute inflammatory disease, can cause a rapid response in clinic, which endangers the patient's life. The components of platycodon grandiflorum, such as platycodins have wide range pharmacological activities expectorant, anti-apoptotic, anti-inflammatory, anti-tumor and anti-oxidant properties, be used for improving human immunity. Previous studies shown that aqueous extract grandiflorum (PAE) has certain protective effect on ALI, but main pharmacodynamic...
Structure–activity relationship of mechanophores has always been a research focus in the field polymer mechanochemistry. Here, we report our investigation effects substitution and pulling geometry on mechanochemical reactivity anthracene–maleimide Diels–Alder (DA) adducts. The results both ultrasonication experiments constrained geometries simulate external force (CoGEF) calculations show that adducts with same points at 9-position anthracene N atom succinimide but different substituents...
Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was explore the unclear protective mechanism catalpol against triptolide. detoxification effect on triptolide investigated in HepaRG cell line. effects were assessed by measuring viability, autophagy, and apoptosis, as well endoplasmic reticulum stress protein mRNA expression levels. We found that 5-20 µg/L treatments increased levels alanine aminotransferase (ALT),...